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Cardiovascular Influences on Blood Pressure

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Pediatric Hypertension

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Abstract

The regulation of the heart and the vasculature are linked by two fundamental principles – that the metabolic state of each organ or tissue is dependent on the relationship between metabolism and blood flow and that each organ or tissue has the ability to control its own blood flow according to local metabolic and functional needs. On a whole-body level, these principles are mediated through blood pressure homeostasis (a closed negative feedback loop that regulates mean arterial pressure around a set reference level). Mean systemic arterial pressure is defined as the product of the sum of all regional blood flows (cardiac output) and the parallel sum of all regional vascular resistances (total systemic vascular resistance). The current chapter discusses the main factors that regulate both cardiac output and systemic vascular resistance and how they relate to the potential pathogenesis of systemic hypertension.

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Author information

Authors and Affiliations

  1. Pediatrics University of Michigan, University of Michigan Congenital Heart Center, C.S. Mott Children’s Hospital, 1540 East Medical center Drive, Ann Arbor, MI, 48109-4204, USA

    Albert P. Rocchini MD

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  1. Albert P. Rocchini MD
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Correspondence to Albert P. Rocchini MD .

Editor information

Editors and Affiliations

  1. University of Washington School of Medicine, Department of Pediatrics and Seattle Children’s Hospital Division of Nephrology, Seattle, WA, USA

    Joseph T. Flynn

  2. Division of Nephrology MassGeneral for Children at Massachusetts General Hospital, Harvard Medical School Department of Pediatrics, Boston, MA, USA

    Julie R. Ingelfinger

  3. St. Luke’s Health System, Children’s Nephrology and Hypertension, Boise, ID, USA

    Karen M. Redwine

Section Editor information

  1. Pediatric Nephrology Unit, MassGeneral Hospital for Children at MGH, Harvard Medical School, Fruit St. 55, 02114, Boston, MA, USA

    Julie R. Ingelfinger M.D.

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Rocchini, A.P. (2018). Cardiovascular Influences on Blood Pressure. In: Flynn, J., Ingelfinger, J., Redwine, K. (eds) Pediatric Hypertension. Springer, Cham. https://doi.org/10.1007/978-3-319-31107-4_3

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  • DOI: https://doi.org/10.1007/978-3-319-31107-4_3

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-31106-7

  • Online ISBN: 978-3-319-31107-4

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