Abstract
Tracheobronchial amyloidosis (TBA) is an unusual disease of the central airway with associated obstructive airway symptoms and some characteristic radiographic and bronchoscopic findings. Diagnosis and clinical management has evolved over the years. This entity typically mimics other common airway diseases such as asthma. When identified, an evaluation of systemic diseases that cause secondary amyloidosis is indicated. A combination of endobronchial therapies and low-dose radiation therapy is the main stay of therapy.
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References
Berk JL, O’Regan A, Skinner M. Pulmonary and tracheobronchial amyloidosis. Semin Respir Crit Care Med. 2002;23:155–65.
Berraondo J, Novella L, Sanz F, Lluch R, de Casimiro E, Lloret T. Management of tracheobronchial amyloidosis with therapeutic bronchoscopic techniques. Arch Bronconeumol. 2013;49:207–9.
Ding L, Li W, Wang K, Chen Y, Xu H, Wang H, Shen H. Primary tracheobronchial amyloidosis in China: analysis of 64 cases and a review of literature. J Huazhong Univ Sci Technol Med Sci. 2010;30:599–603.
Poovaneswaran S, Razak AR, Lockman H, Bone M, Pollard K, Mazdai G. Tracheobronchial amyloidosis: utilization of radiotherapy as a treatment modality. Medscape J Med. 2008;10:42.
Rodrigues K, Neves FS, Stoeterau KB, Werner Castro GR, Nobre LF, Zimmermann AF, Pereira IA. Pulmonary amyloidosis in Sjogren’s syndrome: a rare diagnosis for nodular lung lesions. Int J Rheum Dis. 2009;12:358–60.
Inaty H, Folch E, Stephen C, Majid A. Tracheobronchial amyloidosis in a patient with sjogren syndrome. J Bronchology Interv Pulmonol. 2013;20:261–5.
Oka H, Ishii H, Iwasaki T, Amemiya Y, Otani S, Yoshioka D, Kishi K, Shirai R, Tokimatsu I, Kadota J. Tracheobronchial amyloidosis in a patient with sarcoidosis. Intern Med. 2009;48:1715–6.
Turkstra F, Rinkel RN, Biermann H, van der Valk P, Voskuyl AE. Tracheobronchomalacia due to amyloidosis in a patient with rheumatoid arthritis. Clin Rheumatol. 2008;27:807–8.
Obusez EC, Jamjoom L, Kirsch J, Gildea T, Mohammed TL. Computed tomography correlation of airway disease with bronchoscopy: part I–nonneoplastic large airway diseases. Curr Probl Diagn Radiol. 2014;43:268–77.
Acar T, Bayraktaroglu S, Ceylan N, Savas R. Computed tomography findings of tracheobronchial system diseases: a pictorial essay. Jpn J Radiol. 2015;33:51–8.
M’Rad S, Le Thi Huong D, Wechsler B, Monsigny M, Buthiau D, Colchen A, Godeau P. Localized tracheobronchial amyloidosis. A new case studied with x-ray computed tomographic and nuclear magnetic resonance. Review of the literature. Rev Pneumol Clin. 1988;44:260–65.
Soussan M, Ouvrier MJ, Pop G, Galas JL, Neuman A, Weinmann P. Tracheobronchial FDG uptake in primary amyloidosis detected by PET/CT. Clin Nucl Med. 2011;36:723–4.
Shaheen NA, Salman SD, Nassar VH. Fatal bronchopulmonary hemorrhage due to unrecognized amyloidosis. Arch Otolaryngol. 1975;101:259–61.
Zhang LQ, Zhao YC, Wang XW, Yang J, Lu ZW, Cheng YS. Primary localized tracheobronchial amyloidosis presenting with massive hemoptysis: a case report and literature review. Clin Respir J. 2015.
Newton RC, Kemp SV, Yang GZ, Darzi A, Sheppard MN, Shah PL. Tracheobronchial amyloidosis and confocal endomicroscopy. Respiration. 2011;82:209–11.
Fiorelli A, Accardo M, Galluccio G, Santini M. Tracheobronchial amyloidosis treated by endobronchial laser resection and self expanding Y stent. Arch Bronconeumol. 2013;49:303–5.
Alloubi I, Thumerel M, Begueret H, Baste JM, Velly JF, Jougon J. Outcomes after bronchoscopic procedures for primary tracheobronchial amyloidosis: retrospective study of 6 cases. Pulm Med. 2012;2012:352719.
Brill AK, Woelke K, Schadlich R, Weinz C, Laier-Groeneveld G. Tracheobronchial amyloidosis–bronchoscopic diagnosis and therapy of an uncommon disease: a case report. J Physiol Pharmacol. 2007;58(Suppl 5):51–5.
Ren S, Ren G. External beam radiation therapy is safe and effective in treating primary pulmonary amyloidosis. Respir Med. 2012;106:1063–9.
Kurrus JA, Hayes JK, Hoidal JR, Menendez MM, Elstad MR. Radiation therapy for tracheobronchial amyloidosis. Chest. 1998;114:1489–92.
Truong MT, Kachnic LA, Grillone GA, Bohrs HK, Lee R, Sakai O, Berk JL. Long-term results of conformal radiotherapy for progressive airway amyloidosis. Int J Radiat Oncol Biol Phys. 2012;83:734–9.
Monroe AT, Walia R, Zlotecki RA, Jantz MA. Tracheobronchial amyloidosis: a case report of successful treatment with external beam radiation therapy. Chest. 2004;125:784–9.
Neben-Wittich MA, Foote RL, Kalra S. External beam radiation therapy for tracheobronchial amyloidosis. Chest. 2007;132:262–7.
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Cumbo-Nacheli, G., Doyle, A.D., Gildea, T.R. (2016). Tracheobronchial Amyloidosis. In: Mehta, A., Jain, P., Gildea, T. (eds) Diseases of the Central Airways. Respiratory Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-29830-6_6
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DOI: https://doi.org/10.1007/978-3-319-29830-6_6
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