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Cyclodextrins in Ocular Drug Delivery

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Nano-Biomaterials For Ophthalmic Drug Delivery

Abstract

Cyclodextrins are a group of water-insoluble, donut-shaped, naturally occurring cyclic oligosaccharides that are produced as a result of the bacterial breakdown of α-d-glucose polymers, such as cellulose. They are inactive molecules that do not display any innate biological activity. The ocular delivery of certain drugs is affected not only by the drug’s physicochemical properties but also by the anatomical barriers of the eye. Drug-cyclodextrin complexes, formed by the physical occlusion of the torus cavity by the drug molecule, redress this issue. Thus, the ocular delivery of glaucoma drugs (e.g., carbonic anhydrase inhibitors, prostaglandin derivatives, pilocarpine), nonsteroidal anti-inflammatory drugs (e.g., indomethacin), and antifungal drugs (e.g., voriconazole) is enhanced by such inclusion complexes. Additionally, specific drug delivery systems (e.g., hydrogels, mucoadhesives, ocular gels) are harnessed to deliver the drug payload from the drug-cyclodextrin complex in a tunable fashion. This chapter seeks to elaborate on the chemical, biological, and pharmaceutical aspects governing cyclodextrins in the context of ocular drug delivery.

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Author information

Authors and Affiliations

  1. Department of Pharmaceutical Sciences, Wegmans School of Pharmacy, St. John Fisher College, Rochester, NY, USA

    Sridhar Anand

  2. Rua Sebastião Gonçalves Coelho, 400 Chanadour, Divinópolis, MG, Brazil

    Vanildo Martins Lima Braga

Authors
  1. Sridhar Anand
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  2. Vanildo Martins Lima Braga
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Correspondence to Sridhar Anand .

Editor information

Editors and Affiliations

  1. College of Pharmacy, University of South Florida Health, Tampa, Florida, USA

    Yashwant Pathak

  2. College of Pharmacy, University of South Florida Health, Tampa, Florida, USA

    Vijaykumar Sutariya

  3. College of Pharmacy, University of South Florida, Tampa, Florida, USA

    Anjali A. Hirani

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Anand, S., Braga, V.M.L. (2016). Cyclodextrins in Ocular Drug Delivery. In: Pathak, Y., Sutariya, V., Hirani, A. (eds) Nano-Biomaterials For Ophthalmic Drug Delivery. Springer, Cham. https://doi.org/10.1007/978-3-319-29346-2_12

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