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miRNA Regulation in Dental Stem Cells: From Development to Terminal Differentiation

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Dental Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Dental Stem Cells (DSCs) are emerging adult stem cells (ASCs) as a good cell source for stem cell-based therapies and tissue engineering approaches. MicroRNAs (miRNAs) are approximately 20 nucleotide long small RNA molecules which can coordinate many genes and pathways. miRNAs effectively regulate stem cell types ranging from embryonic stem cells (ESCs) to mesenchymal stem cells (MSCs), and DSCs are no exception. Numerous studies in which miRNA profiling of DSCs from different sources of the mature and immature teeth including pulp, periodontal ligament, follicle and apical papilla tissues have been made in order to determine the role of specific miRNAs in various functions, which may be important for DSC biology. Moreover, the miRNA expression levels are being monitored both between different steps of differentiation and in cells that are differentiated in vitro. Such data will help to better retain stemness of cells, and manipulate the differentiation process into desired lineages. In this book chapter, we seek to compile data resulting from miRNA studies in DSCs.

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Authors and Affiliations

  1. Department of Medical Genetics, Yeditepe University Medical School and Yeditepe University Hospital, Istanbul, Turkey

    Sukru Gulluoglu & Omer Faruk Bayrak

  2. Department of Biotechnology, Institute of Science, Yeditepe University, Istanbul, Turkey

    Sukru Gulluoglu & Emre Can Tuysuz

Authors
  1. Sukru Gulluoglu
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  2. Emre Can Tuysuz
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  3. Omer Faruk Bayrak
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Correspondence to Omer Faruk Bayrak .

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Editors and Affiliations

  1. Yeditepe University, Genetics and Bioengineering Department, Istanbul, Turkey

    Fikrettin Şahin

  2. Yeditepe University, Genetics and Bioengineering Department, Istanbul, Turkey

    Ayşegül Doğan

  3. Yeditepe University, Genetics and Bioengineering Department, ISTANBUL, Turkey

    Selami Demirci

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Gulluoglu, S., Tuysuz, E.C., Bayrak, O.F. (2016). miRNA Regulation in Dental Stem Cells: From Development to Terminal Differentiation. In: Şahin, F., Doğan, A., Demirci, S. (eds) Dental Stem Cells. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-28947-2_3

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