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Cytomegalovirus Infection After Stem Cell Transplantation

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Transplant Infections

Abstract

Human cytomegalovirus (CMV) continues to be a cause of substantial morbidity and mortality in the hematopoietic cell transplant (HCT) recipient. Sensitive and rapid turnaround quantitative polymerase chain reaction (qPCR)-based monitoring coupled with the availability of effective antiviral therapy has reduced the overall burden of CMV disease after HCT. However, the increasing use of techniques such as cord blood and T-cell-depleted haploidentical transplant presents new challenges in the prevention and treatment of CMV. Gastrointestinal disease is now the most common end-organ manifestation of CMV infection after HCT, whereas pneumonia remains associated with high mortality. In addition, indirect effects of CMV infection continue to have both positive and negative effects on outcomes after HCT. Antivirals with novel mechanisms of action and improved toxicity profiles compared to those currently available are very much needed. The development of an effective vaccine has proven to be difficult. Therefore, CMV is likely to remain a significant pathogen in the HCT recipient in the years to come.

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Authors and Affiliations

  1. Division of Infectious Diseases, Department of Internal Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd., L457, Portland, OR, 97239, USA

    Morgan Hakki M.D.

  2. Department of Hematology, Karolinska University Hospital, M54, Stockholm, 14186, Sweden

    Per Ljungman M.D., Ph.D.

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  1. Morgan Hakki M.D.
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  2. Per Ljungman M.D., Ph.D.
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Correspondence to Morgan Hakki M.D. .

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Editors and Affiliations

  1. Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

    Per Ljungman

  2. Tufts University School of Medicine Tufts Medical Center, Boston, MA, USA

    David Snydman

  3. University of Washington Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Michael Boeckh

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Hakki, M., Ljungman, P. (2016). Cytomegalovirus Infection After Stem Cell Transplantation. In: Ljungman, P., Snydman, D., Boeckh, M. (eds) Transplant Infections. Springer, Cham. https://doi.org/10.1007/978-3-319-28797-3_24

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  • DOI: https://doi.org/10.1007/978-3-319-28797-3_24

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