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The Neuroimmunology of Gluten Intolerance

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Neuro-Immuno-Gastroenterology

Abstract

The term gluten-related disorders (GRD) denotes a spectrum of diverse immune-mediated diseases triggered by the ingestion of gluten (protein found in wheat, barley and rye). Coeliac disease (CD) or gluten-sensitive enteropathy is the most recognised and studied entity within GRD. Extraintestinal manifestations are gaining recognition and are increasingly the subject of further studies as they may hold the key to unravelling the pathophysiology of GRD. Such manifestations include skin involvement in the form of dermatitis herpetiformis (DH) and neurological dysfunction (e.g. gluten ataxia and gluten neuropathy). Furthermore, the recent concept of extraintestinal manifestations without enteropathy (termed non-coeliac gluten sensitivity (NCGS)) has become accepted as part of the same spectrum. In this chapter, we review the neurological manifestations in GRD and discuss recent advances in diagnosis and possible pathophysiological mechanisms.

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Authors and Affiliations

  1. Department of Neurosciences, Royal Hallamshire Hospital, Sheffield, South Yorkshire, UK

    Marios Hadjivassiliou MD, FRCP

  2. Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield, South Yorkshire, UK

    David S. Sanders FRCP, MD

  3. Matrix Biology & Tissue Repair Research Unit/Arthritis Research UK Centre of Excellence for Biomechanics and Bioengineering, College of Biomedical and Life Sciences, Cardiff University, School of Dentistry, Heath Park, Cardiff, UK

    Daniel Aeschlimann PhD

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  1. Marios Hadjivassiliou MD, FRCP
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  2. David S. Sanders FRCP, MD
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  3. Daniel Aeschlimann PhD
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Correspondence to Marios Hadjivassiliou MD, FRCP .

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  1. Neurology, C Floor South Block, University of Nottingham, Nottingham, United Kingdom

    Cris Constantinescu

  2. Atlantic Digestive Health Institute, Morristown Medical Center, Columbus, Ohio, USA

    Razvan Arsenescu

  3. Armedica LLC, Columbus, Ohio, USA

    Violeta Arsenescu

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Hadjivassiliou, M., Sanders, D.S., Aeschlimann, D. (2016). The Neuroimmunology of Gluten Intolerance. In: Constantinescu, C., Arsenescu, R., Arsenescu, V. (eds) Neuro-Immuno-Gastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-319-28609-9_15

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