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Natural History and Impact of Interventions on CAC

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Cardiac CT Imaging

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Abstract

Coronary artery calcium is a marker of sub-clinical atherosclerosis and it is deposited via an active process similar to bone formation. Sequential non-contrast CT has been proposed as a method to accurately quantify and monitor progression of calcification. While interventions have generally failed to slow progression of calcification, it has become apparent that continued progression of CAC is associated with an increased risk of myocardial infarction and cardiac death. As a consequence, researchers have implemented sequential cardiac CT to follow the progression of coronary artery calcium in a variety of clinical settings and in some cases have reported encouraging results.

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  1. Department of Medicine, Mazankowski Alberta Heart Institute, University of Alberta, 4A7.050, 8440 – 112 Street, Edmonton, AB, T6G 2B7, Canada

    Paolo Raggi MD

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  1. Division of Cardiology, Harbor-UCLA Medical Center, Torrance, California, USA

    Matthew J. Budoff

  2. Keck School of Medicine, University of Southern California, Los Angeles, California, USA

    Jerold S. Shinbane

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Raggi, P. (2016). Natural History and Impact of Interventions on CAC. In: Budoff, M., Shinbane, J. (eds) Cardiac CT Imaging. Springer, Cham. https://doi.org/10.1007/978-3-319-28219-0_6

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