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Introduction and epidemiology of meningococcal disease

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Handbook of Meningococcal Disease Management

Abstract

Neisseria meningitidis, the meningococcus, is a Gram-negative diplococcal bacterium that is only found naturally in humans. The meningococcus is part of the normal microbiota of the human nasopharynx and is commonly carried in healthy individuals (Chapter 2). In rare cases systemic invasion occurs, which can lead to meningitis and/or septicemia. Other clinical manifestations of meningococcal infection include pneumonia, urethritis, conjunctivitis, septic arthritis, and pericarditis.

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References

  1. Weichselbaum A. Ãœeber die Aetiologie der akuten Meningitis Cerebrospinalis. Fortschr Med. 1887;5:14.

    Google Scholar 

  2. Vieusseux M. Mémoire sur la maladie qui a regné a Genêve au printemps de 1805.J Med Chir Pharm. 1805;11:19.

    Google Scholar 

  3. Harrison OB, Claus H, Jiang Y, et al. Description and nomenclature of Neisseria meningitidis capsule locus. Emerg Infect Dis. 2013;19:566–573.

    Google Scholar 

  4. Russell JE, Jolley KA, Feavers IM, Maiden MC, Suker J. PorA variable regions of Neisseria meningitidis. Emerg Infec Dis. 2004;10:674–678.

    Google Scholar 

  5. Jolley KA, Brehony C, Maiden MC. Molecular typing of meningococci: recommendations for target choice and nomenclature. FEMS Microbiol ver. 2007;31:89–96.

    Google Scholar 

  6. Harrison LH, Trotter CL, Ramsay ME. Global epidemiology of meningococcal disease. Vaccine. 2009;27 (Suppl 2):B51–63.

    Google Scholar 

  7. Case definitions for reporting communicable diseases. European Union Commission website. eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri = OJ:L:2008:159:0046:0090:EN:PDF. Accessed January 19, 2015.

    Google Scholar 

  8. Ladhani SN, Flood JS, Ramsay ME, et al. Invasive meningococcal disease in England and Wales: implications for the introduction of new vaccines. Vaccine. 2012;30:3710–3716.

    Google Scholar 

  9. Cohn AC, MacNeil JR, Harrison LH, et al. Changes in Neisseria meningitidis disease epidemiology in the United States, 1998–2007: implications for prevention of meningococcal disease. Clin Infect Dis. 2010;50:184–191.

    Google Scholar 

  10. Trotter CL, Chandra M, Cano R, et al. A surveillance network for meningococcal disease in Europe. FEMS Microbiol ver. 2007;31:27–36.

    Google Scholar 

  11. Ramakrishnan M, Ulland AJ, Steinhardt LC, Moisi JC, Were F, Levine OS. Sequelae due to bacterial meningitis among African children: a systematic literature review. BMC Med. 2009;7:47.

    Google Scholar 

  12. Edmond K, Clark A, Korczak VS, Sanderson C, Griffiths UK, Rudan I. Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10:317–328.

    Google Scholar 

  13. Erickson L, De Wals P. Complications and sequelae of meningococcal disease in Quebec, Canada, 1990–1994. Clin Infect Dis. 1998;26:1159–1164.

    Google Scholar 

  14. Greenwood B. Manson Lecture. Meningococcal meningitis in Africa. Trans R Soc Trop Med Hyg. 1999;93:341–353.

    Google Scholar 

  15. European Centre for Disease Prevention and Control. Surveillance of invasive bacterial diseases in Europe, 2012. Stockholm: ECDC; 2015.

    Google Scholar 

  16. Goldschneider I, Gotschlich EC, Artenstein MS. Human immunity to the meningococcus. I. The role of humoral antibodies. J Exp Med. 1969;129:1307–1326.

    Google Scholar 

  17. Ameratunga S, Macmillan A, Stewart J, et al. Evaluating the post-licensure effectiveness of a group B meningococcal vaccine in New Zealand: a multi-faceted strategy. Vaccine. 2005;23:2231–2234.

    Google Scholar 

  18. Campagne G, Schuchat A, Djibo S, Ousseini A, Cisse L, Chippaux JP. Epidemiology of bacterial meningitis in Niamey, Niger, 1981–96. Bull World Health Organ. 1999;77:499–508.

    Google Scholar 

  19. Agier L, Deroubaix A, Martiny N, Yaka P, Djibo A, Broutin H. Seasonality of meningitis in Africa and climate forcing: aerosols stand out. J R Soc, Interface. 2013;10:20120814.

    Google Scholar 

  20. Heyderman RS, Ben-Shlomo Y, Brennan CA, Somerset M. The incidence and mortality for meningococcal disease associated with area deprivation: an ecological study of hospital episode statistics. Arch Dis Child. 2004;89:1064–1068.

    Google Scholar 

  21. De Wals P, Hertoghe L, Borlee-Grimee I, et al. Meningococcal disease in Belgium. Secondary attack rate among household, day-care nursery and pre-elementary school contacts. J Infect. 1981;3:53–61.

    Google Scholar 

  22. Lewis LA, Ram S. Meningococcal disease and the complement system. Virulence. 2014;5:98–126.

    Google Scholar 

  23. Cohen C, Singh E, Wu HM, et al. Increased incidence of meningococcal disease in HIVinfected individuals associated with higher case-fatality ratios in South Africa. Aids. 2010;24:1351–1360.

    Google Scholar 

  24. Coen PG, Tully J, Stuart JM, Ashby D, Viner RM, Booy R. Is it exposure to cigarette smoke or to smokers which increases the risk of meningococcal disease in teenagers? Int J Epidemiol. 2006;35:330–336.

    Google Scholar 

  25. Norheim G, Sadarangani M, Omar O, et al. Association between population prevalence of smoking and incidence of meningococcal disease in Norway, Sweden, Denmark and the Netherlands between 1975 and 2009: a population-based time series analysis. BMJ Open. 2014;4:e003312.

    Google Scholar 

  26. Jacobs JH, Viboud C, Tchetgen ET, et al. The association of meningococcal disease with influenza in the United States, 1989-2009. PloS One. 2014;9:e107486.

    Google Scholar 

  27. Lapeyssonnie L. [Cerebrospinal Meningitis in Africa]. Bull World Health Organ. 1963;28 Suppl:1–114.

    Google Scholar 

  28. Daugla D, Gami J, Gamougam K, et al. Effect of a serogroup A meningococcal conjugate vaccine (PsA-TT) on serogroup A meningococcal meningitis and carriage in Chad: a community trial. Lancet. 2014;383:40–47.

    Google Scholar 

  29. Ceyhan M, Anis S, Htun-Myint L, Pawinski R, Soriano-Gabarro M, Vyse A. Meningococcal disease in the Middle East and North Africa: an important public health consideration that requires further attention. Int J of Infect Dis. 2012;16:e574–582.

    Google Scholar 

  30. Public Health England website. www.gov.uk/government/uploads/system/uploads/attachment_data/file/343375/Table_1a_Invasive_meningococcal__E_W_by_capsular_group___epi_year.pdf. Accessed January 19, 2015.

  31. Active Bacterial Core Surveillance Report Emerging Infections Program Network. Centers for Disease Control and Prevention website. www.cdc.gov/abcs/reports-findings/survreports/mening12.pdf. Accessed January 19, 2015.

  32. Sadarangani M, Scheifele DW, Halperin SA, et al. The Impact of the Meningococcal Serogroup C Conjugate Vaccine in Canada Between 2002 and 2012. Clin Infect Dis. 2014;59:1208–1215.

    Google Scholar 

  33. Safadi MA, Gonzalez-Ayala S, Jakel A, Wieffer H, Moreno C, Vyse A. The epidemiology of meningococcal disease in Latin America 1945–2010: an unpredictable and changing landscape. Epidemiol Infect. 2013;141:447–458.

    Google Scholar 

  34. Abad R, Lopez EL, Debbag R, Vazquez JA. Serogroup W meningococcal disease: global spread and current affect on the Southern Cone in Latin America. Epidemiol Infect. 2014;142:2461–2470.

    Google Scholar 

  35. John TJ, Gupta S, Chitkara AJ, Dutta AK, Borrow R. An overview of meningococcal disease in India: knowledge gaps and potential solutions. Vaccine. 2013;31:2731–2737.

    Google Scholar 

  36. Zhou H, Shan X, Sun X, et al. Clonal characteristics of invasive Neisseria meningitidis following initiation of an A+C vaccination program in China, 2005–2012. J Infect. 2014;70:37–43.

    Google Scholar 

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Trotter, C., Ramsay, M., Harrison, L. (2016). Introduction and epidemiology of meningococcal disease. In: Feavers, I., Pollard, A., Sadarangani, M. (eds) Handbook of Meningococcal Disease Management. Adis, Cham. https://doi.org/10.1007/978-3-319-28119-3_1

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  • DOI: https://doi.org/10.1007/978-3-319-28119-3_1

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