Skip to main content

Multidisciplinary Approach of Unresectable Head and Neck Cancer

  • Chapter
  • First Online:
Head and Neck Cancer

Abstract

The management of locally advanced head and neck cancer has seen the emergence of different combined modality therapies in recent years and new types of treatments, such as chemoradiation, new induction chemotherapy schemes, and salvage surgery.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 219.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 279.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Haddad RI, Shin DM. Recent advances in head and neck cancer. N Engl J Med. 2008;359:1143–54.

    Article  CAS  PubMed  Google Scholar 

  2. Licitra L, Locati LD, Bossi P. Optimizing approaches to head and neck cancer. Metastatic head and neck cancer: new options. Ann Oncol. 2008;19 Suppl 7:vii200–3.

    PubMed  Google Scholar 

  3. Edge SB, Byrd DR, Compton CC. AJCC cancer staging manual. 7th ed. New York, NY: Springer; 2010.

    Google Scholar 

  4. Yousem DM, Hatabu H, Hurst RW, Seigerman HM, Montone KT, Weinstein GS, et al. Carotid artery invasion by head and neck masses: prediction with MR imaging. Radiology. 1995;195:715–20.

    Article  CAS  PubMed  Google Scholar 

  5. Yousem DM, Gad K, Tufano RP. Resectability issues with head and neck cancer. AJNR Am J Neuroradiol. 2006;27:2024–36.

    CAS  PubMed  Google Scholar 

  6. Hsu WC, Loevner LA, Karpati R, Ahmed T, Mong A, Battineni ML, et al. Accuracy of magnetic resonance imaging in predicting absence of fixation of head and neck cancer to the prevertebral space. Head Neck. 2005;27:95–100.

    Article  PubMed  Google Scholar 

  7. Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17(6):1471–4.

    Article  PubMed  Google Scholar 

  8. Pons Y, Ukkola-Pons E, Clément P, Gauthier J, Conessa C. Relevance of 5 different imaging signs in the evaluation of carotid artery invasion by cervical lymphadenopathy in head and neck squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109(5):775–8.

    Article  PubMed  Google Scholar 

  9. Lodder WL, Lange CAH, Teertstra HJ, Pameijer FA, van den Brekel MWM, Balm AJM. Value of MR and CT imaging for assessment of internal carotid artery encasement in head and neck squamous cell carcinoma. Int J Surg Oncol [Internet]. 2013;2013:1–6.

    Article  Google Scholar 

  10. Lee C-C, Chu S-T, Chou P, Lee C-C, Chen L-F. The prognostic influence of prevertebral space involvement in nasopharyngeal carcinoma. Clin Otolaryngol. 2008;33(5):442–9.

    Article  PubMed  Google Scholar 

  11. Feng A-C, Wu M-C, Tsai SYC, Chan K-Y, Cheng SH, Wang A, et al. Prevertebral muscle involvement in nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys [Internet]. 2006;65(4):1026–35.

    Article  Google Scholar 

  12. Righi PD, Kelley DJ, Ernst R, Deutsch MD, Gaskill-Shipley M, Wilson KM, et al. Evaluation of prevertebral muscle invasion by squamous cell carcinoma. Can computed tomography replace open neck exploration? Arch Otolaryngol Head Neck Surg. 1996;122(6):660–3.

    Article  CAS  PubMed  Google Scholar 

  13. Loevner LA, Ott IL, Yousem DM, Montone KT, Thaler ER, Chalian AA, et al. Neoplastic fixation to the prevertebral compartment by squamous cell carcinoma of the head and neck. AJR Am J Roentgenol. 1998;170(5):1389–94.

    Article  CAS  PubMed  Google Scholar 

  14. Wong YK, Novotny GM. Retropharyngeal space – a review of anatomy, pathology, and clinical presentation. J Otolaryngol. 1978;7(6):528–36.

    CAS  PubMed  Google Scholar 

  15. Wang J, Takashima S, Matsushita T, Takayama F, Kobayashi T, Kadoya M. Esophageal invasion by thyroid carcinomas: prediction using magnetic resonance imaging. J Comput Assist Tomogr. 2003;27(1):18–25.

    Article  PubMed  Google Scholar 

  16. Wang JC, Takashima S, Takayama F, Kawakami S, Saito A, Matsushita T, et al. Tracheal invasion by thyroid carcinoma: prediction using MR imaging. AJR Am J Roentgenol. 2001;177(4):929–36.

    Article  CAS  Google Scholar 

  17. Parker G, Harnsberger H. Clinical-radiologic issues in perineural tumor spread of malignant diseases of the extracranial head and neck. Radiographics. 1991;11:383–99.

    Article  CAS  PubMed  Google Scholar 

  18. Adelstein DJ, Li Y, Adams GL, Wagner Jr H, Kish JA, Ensley JF, et al. An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol. 2003;21:92–8.

    Article  PubMed  Google Scholar 

  19. Haselow R, Warshaw M, Oken M, et al. Radiation alone versus radiation with weekly low dose cis-platinum in unresectable cancer of the head and neck. In: Fee Jr WE, Goepfert H, Johns ME, et al., editors. Head and neck cancer, vol. II. Philadelphia, PA: Lippincott; 1990. p. 279–81.

    Google Scholar 

  20. Agarwala SS, Cano E, Heron DE, Johnson J, Myers E, Sandulache V, et al. Long-term outcomes with concurrent carboplatin, paclitaxel and radiation therapy for locally advanced, inoperable head and neck cancer. Ann Oncol. 2007;18:1224–9.

    Article  CAS  PubMed  Google Scholar 

  21. Sutharalingum M, Haas M, Conley B, Egorin M, Levy S, Sivisailam S, et al. The use of carboplatin and paclitaxel with daily radiotherapy in patients with locally advanced squamous cell carcinomas of the head and neck. Int J Radiat Biol Oncol Phys. 2000;47:49–56.

    Article  Google Scholar 

  22. Medina JA, Rueda A, de Pasos AS, Contreras J, Cobo M, Moreno P, et al. A phase II study of concomitant boost radiation plus concurrent weekly cisplatin for locally advanced unresectable head and neck carcinomas. Radiother Oncol. 2006;79:34–8.

    Article  CAS  PubMed  Google Scholar 

  23. Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354:567–78.

    Article  CAS  PubMed  Google Scholar 

  24. Langer C, Lee J, Patel U, Shin D, Argiris A, Quon H, et al. Preliminary analysis of ECOG 3303: concurrent radiation (RT), cisplatin (DDP) and cetuximab (C) in unresectable, locally advanced (LA) squamous cell carcinoma of the head and neck (SCCHN). J Clin Oncol. 2008;26 (May 20 suppl; abstr 6006).

    Google Scholar 

  25. Pignon JP, Bourhis J, Domenge C, Designe L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet. 2000;355:949–55.

    Article  CAS  PubMed  Google Scholar 

  26. Vermorken JB, Remenar E, van Herpen C, Gorlia T, Mesia R, Degardin M, et al. Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer. N Engl J Med. 2007;357:1695–704.

    Article  CAS  PubMed  Google Scholar 

  27. Posner MR, Hershock DM, Blajman CR, Mickiewicz E, Winquist E, Gorbounova V, et al. Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer. N Engl J Med. 2007;357:1705–15.

    Article  CAS  PubMed  Google Scholar 

  28. Hitt R, Lopez-Pousa A, Martinez-Trufero J, Escrig V, Carles J, Rizo A, et al. Phase III study comparing cisplatin plus fluorouracil to paclitaxel, cisplatin, and fluorouracil induction chemotherapy followed by chemoradiotherapy in locally advanced head and neck cancer. J Clin Oncol. 2005;23:8636–45.

    Article  PubMed  Google Scholar 

  29. Hitt R, Grau J, Lopez-Pousa A, Berrocal A, Garcia Giron C, Irigoyen A, et al. Final results of a randomized phase III trial comparing induction chemotherapy with cisplatin/5-FU or docetaxel/cisplatin/5-FU followed by chemoradiotherapy (CRT) versus CRT alone as first-line treatment of unresectable locally advanced head and neck cancer (LAHNC). J Clin Oncol. 2009;27:15S (suppl; abstr 6009).

    Article  Google Scholar 

  30. Ghi MG, Paccagnella A, Ferrari D, et al. Concomitant CRT or Cetuximab/RT vs. induction docetaxel/cisplatin/5FU (TPF) followed by CRT or cetuximab/RT in patients with LASCCHN. A randomized phase III factorial study. Efficacy results (NCT01086826). ASCO annual meeting Chicago 2014.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ricardo Hitt MD, PhD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Hitt, R., Lopez-Martin, A., Cruz, J.J., Haddad, R.I. (2016). Multidisciplinary Approach of Unresectable Head and Neck Cancer. In: Bernier, J. (eds) Head and Neck Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-27601-4_35

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-27601-4_35

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-27599-4

  • Online ISBN: 978-3-319-27601-4

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics