Skip to main content

Lymphoblastic Lymphoma in Children and Adolescents: Introduction

  • Chapter
  • First Online:
PET/CT in Lymphomas

Abstract

Lymphoblastic lymphomas (LBL), like acute lymphoblastic leukemia (ALL), comprise of high-grade neoplasms arising from precursor lymphocytes of B- or T-cell lineage. In the great majority, they are of T-cell lineage (more than 75 %) and localize to the mediastinum (more than 80 %), whereas the less frequent B-cell lineage lymphomas have various primary sites. Mediastinal, bone marrow, and CNS involvements are more common in T-LBL, whereas skin, lymph node, and bone involvements are observed most frequently in B-LBL [1]. The incidence of LBL remains relatively constant across ages for both males and females.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Jaffe ES, Harris NL, Stein H et al (2008) Introduction and overview of the classification of the lymphoid neoplasms. In: Swerdlow SH, Campo E, Harris NL et al (eds) WHO classification of tumours of haematopoietic and lymphoid tissues, 4th edn. Int Agency Res Cancer, Lyon, pp 157–166

    Google Scholar 

  2. Kostakoglu L, Cheson BD (2013) State-of-the-art research on “lymphomas: role of molecular imaging for staging, prognostic evaluation, and treatment response”. Front Oncol 3:Article 212

    Google Scholar 

  3. Montravers F, McNamara D, Landman-Parker J et al (2002) [(18)F]-FDG in childhood lymphoma: clinical utility and impact on management. Eur J Nucl Med Mol Imaging 29:1155–1165

    Article  CAS  PubMed  Google Scholar 

  4. Rosolen A, Gross T (2012). Chapter 17. Malignant non-Hodgkin lymphomas in children. In: Stevens M, Caron H, Biondi A (eds). Cancer in Children. Clinical Management, 6th ed. New York: Oxford University Press, pp 203–219

    Google Scholar 

  5. Hoelzer D, Gokbuget N, Digel W et al (2002) Outcome of adult patients with T-lymphoblastic lymphoma treated according to protocol for acute lymphoblastic leukemia. Blood 99:4379–4385

    Article  CAS  PubMed  Google Scholar 

  6. Reiter A, Schrappe M, Ludwig WD et al (2000) Intensive ALL-type therapy without local radiotherapy provides a 90% event-free survival for children with T-cell lymphoblastic lymphoma: a BFM group report. Blood 95:416–421

    CAS  PubMed  Google Scholar 

  7. Atlas M (2005) Non-Hodgkin lymphoma. In: Lanzkowsky P (ed) Manual of pediatric hematology and oncology. Elsevier Academic Press, London, pp 500–502

    Google Scholar 

  8. Maitra A, McKenna RW, Weinberg AG et al (2001) Precursor B-cell lymphoblastic lymphoma. A study of nine cases lacking blood and bone marrow involvement and review of the literature. Am J Clin Pathol 115:868

    Google Scholar 

  9. Neth O, Seidemann K, Jansen P et al (2000) Precursor B-cell lymphoblastic lymphoma in childhood and adolescence: clinical features, treatment, and results in trials NHL-BFM 86 and 90. Med Pediatr Oncol 35:20–27

    Google Scholar 

  10. Weiler-Sagie M, Bushelev O, Epelbaum R et al (2010) (18)F-FDG avidity in lymphoma readdressed: a study of 766 patients. J Nucl Med 51(1):25–30

    Google Scholar 

  11. Cheng G, Servaes S, Zhuang H (2013) Value of (18)F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography scan versus diagnostic contrast computed tomography in initial staging of pediatric patients with lymphoma. Leuk Lymphoma 54(4):737–742

    Article  CAS  PubMed  Google Scholar 

  12. Kluge R, Kurch L, Montravers F, Mauz-Körholz C (2013) FDG PET/CT in children and adolescents with lymphoma. Pediatr Radiol 43(4):406–417

    Article  PubMed  Google Scholar 

  13. Cistaro A, Saglio F, Asaftei S et al (2011) The role of 18F-FDG PET/CT in pediatric lymph node acute lymphoblastic leukemia involvement. Radiol Case Rep 6(4):503

    Google Scholar 

  14. Cairo MS (2010) Non Hodgkin’s lymphoma and lymphoproliferative disorders in children. In: Carrol WL, Finlay J (eds) Cancer in children and adolescents. Jones and Bartlett Publishers, Sudbury

    Google Scholar 

  15. EI-Mallawany NK et al (2012) Pediatric T- and NK-cell lymphomas: new biologic insights and treatment strategies. Blood Cancer J 2(4):e65. doi:10.1038/bcj.2012.8, Epub 2012 Apr 13

    Article  Google Scholar 

  16. Bhojwani D et al (2015) The role of FDG-PET/CT in the evaluation of residual disease in paediatric non-Hodgkin lymphoma. Br J Haematol 168(6):845–853

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Sandlund JT et al (2015) International pediatric non-Hodgkin lymphoma response criteria. J Clin Oncol. doi:10.1200/JCO.2014.59.0745

    PubMed Central  Google Scholar 

Download references

Acknowledgments

The authors thank Sophia Polychronopoulou and Vassilios Papadakis, Department of Pediatric Hematology-Oncology of “Aghia Sofia” Children’s Hospital, Athens, Greece, and Kalliopi Stefanaki, Department of Pathology of “Aghia Sofia” Children’s Hospital, Athens, Greece, for their contribution by sharing the clinical and imaging data of their patient.

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Apostolos G. Pourtsidis MD or Apostolos G. Pourtsidis MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Pourtsidis, A.G., Dana, H., Nikaki, A.V., Kritikos, N.V. (2016). Lymphoblastic Lymphoma in Children and Adolescents: Introduction. In: Andreou, J., Kosmidis, P., Gouliamos, A. (eds) PET/CT in Lymphomas. Springer, Cham. https://doi.org/10.1007/978-3-319-27380-8_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-27380-8_19

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-27378-5

  • Online ISBN: 978-3-319-27380-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics