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Synovial-Like Neoplasms (Synovial Sarcoma) of the Liver

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Abstract

Synovial sarcoma is an aggressive soft tissue sarcoma of uncertain histogenesis with a predilection for the deep soft tissues of paraarticular regions of the extremities. The tumor predominantly develops in younger adults and accounts for 5–10 % of all soft tissue sarcomas. Apart from extremities, this sarcoma also occurs in various other sites, including visceral organs, the heart and large blood vessels. Most instances of hepatic manifestations of this neoplasm are metastases. However, few cases of monophasic primary hepatic synovial sarcoma have been reported. The tumors are sometimes large and hemorrhagic. Histologically, spindle cells and hemangiopericytoma-like cells prevail, with variable admixtures of epithelioid cells. The tumors are associated with the typical SYT-SSX1 or SYT-SSX2 rearrangement and the corresponding fusion proteins, as in soft tissue synovial sarcomas. Very rarely, synovial sarcoma develops as a primary lesion in the biliary tract.

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    Arthur Zimmermann

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Zimmermann, A. (2017). Synovial-Like Neoplasms (Synovial Sarcoma) of the Liver. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_70

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