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Gastrointestinal Stromal Tumors (GISTs) of the Liver

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Abstract

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors with distinct clinical, morphologic, immunohistochemical, and molecular genetic features. GISTs account for 1–3 % of all gastrointestinal tumors, mainly occur in older adults, and are associated with specific KIT and PDGFRA mutations. Most GISTs immunohistochemically express KIT/CD117. GIST can involve the entire gastrointestinal tract, with a predilection for the stomach and the small intestine, whereas the liver is an uncommon primary location. Primary hepatic GISTs are well-circumscribed, firm tumors that may show central necrosis and satellite lesions. The histologic presentation corresponds to that of GISTs in other sites. Much more common than primary hepatic GIST are metastatic lesions, the liver being one of the most common metastatic sites of gastric and intestinal GIST. Liver metastases of GIST can undergo a distinct cystic change upon therapy with imatinib. Radiologically, part of these cysts closely mimic simple nonparasitic liver cysts.

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  1. University of Bern, Bern, Switzerland

    Arthur Zimmermann

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Zimmermann, A. (2017). Gastrointestinal Stromal Tumors (GISTs) of the Liver. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_67

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  • DOI: https://doi.org/10.1007/978-3-319-26956-6_67

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