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Tumor-Like Lesions of the Hepatobiliary Tract: Granulomatous Masses in Syphilis, Brucellosis, and Cat-Scratch Disease

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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Abstract

Venereal syphilis caused by Treponema pallidum induces a complex spectrum of lesions in the hepatobiliary tract, ranging from a distinct fibrosing disease in connatal syphilis to gummatous hepatitis in adult patients. Early syphilis of the liver is characterized by syphilitic hepatitis, a disorder well known in patients with HIV infection. In later stages of the infection, i.e., in tertiary syphilis, hepatic mass lesions can develop. These include syphilomas and gummas. The latter are macroscopic inflammatory lesions of a firm consistence, an irregular rather than spherical shape, and a geographic pattern on cut surfaces. Mass lesions of the liver can also occur in brucellosis. These lesions are spherical, may have a diameter of more than 5 cm, and are characterized by central necrosis, several layers of granulomatous inflammatory reaction, and a peripheral fibrous demarcation. Necrotic and inflammatory nodular lesions with a granulomatous reaction in the liver also occur in cat-scratch disease.

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    Arthur Zimmermann

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Zimmermann, A. (2017). Tumor-Like Lesions of the Hepatobiliary Tract: Granulomatous Masses in Syphilis, Brucellosis, and Cat-Scratch Disease. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_129

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