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Differentiation of Murine Myeloid-Derived Suppressor Cells

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Myeloid-Derived Suppressor Cells and Cancer

Part of the book series: SpringerBriefs in Immunology ((BRIEFSIMMUN))

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Abstract

Myeloid-derived suppressor cells (MDSCs) are frequently defined as a heterogeneous population of immature cells belonging to the myeloid lineage which possess strong immunosuppressive activities. These cells ultimately derive from myeloid progenitors mainly present in the bone marrow that undergo a dysregulated differentiation pathway, ending up with the systemic mobilization of MDSCs of “monocytic” or “granulocytic” characteristics. Here we will review the current knowledge on MDSC differentiation mostly in murine cancer models, and reflect on whether MDSCs represent a unique, well-defined distinct myeloid lineage or just immature stages of myeloid cells.

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Acknowledgments

David Escors is funded by a Miguel Servet Fellowship (CP12/03114), a FIS project grant (PI14/00579) from the Instituto de Salud Carlos III, Spain, the Refbio transpyrenaic collaborative project grants (NTBM), a Sandra Ibarra Foundation grant, Gobierno de Navarra Grant (BMED 033-2014), and a Gobierno Vasco BioEf project grant (BIO13/CI/014).

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  1. Navarrabiomed-Biomedical Research Centre, Fundación Miguel Servet, IdiSNA, Calle Irunlarrea 3, 31008, Pamplona, Navarra, Spain

    David Escors

  2. Immunomodulation Group, Rayne Building University College London, 5 University Street, London, WC1E 6JF, UK

    David Escors

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Escors, D. (2016). Differentiation of Murine Myeloid-Derived Suppressor Cells. In: Myeloid-Derived Suppressor Cells and Cancer. SpringerBriefs in Immunology. Springer, Cham. https://doi.org/10.1007/978-3-319-26821-7_2

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