Abstract
The diabetes-inducing agent streptozotocin (STZ) is a glucosamine–nitrosourea compound produced by Streptomyces achromogenes, which specifically induces DNA strand breakage in β-cells causing diabetes mellitus. The destruction of pancreatic β-cells by STZ is associated with a huge release of insulin in their first phase, and then in the second phase, the destruction has lead to deficiency of insulin causes hyperglycaemia. A detailed method on selection of diabetic animals, investigation of blood glucose levels, body weight, biochemical and histopathological parameters is presented in this chapter.
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Thangaraj, P. (2016). Evaluation of Anti-diabetic Property on Streptozotocin-Induced Diabetic Rats. In: Pharmacological Assays of Plant-Based Natural Products. Progress in Drug Research, vol 71. Springer, Cham. https://doi.org/10.1007/978-3-319-26811-8_24
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DOI: https://doi.org/10.1007/978-3-319-26811-8_24
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