Abstract
Heart failure (HF) after coronary artery bypass graft (CABG) could be attributed to preoperative HF or postoperative HF. Preoperative HF accounted for about 45 % of patients referred for a condition of HF symptoms with systolic left ventricular (LV) ejection fraction (EF) less than 50 % before the surgery. The goal of treatment in patients with established HF is to relieve symptoms, prevent hospital admission, and improve survival before the surgery. Even though standard medications for HF including beta-blockers, angiotensin-converting enzyme (ACE) inhibitor, and mineralocorticoid have been shown beneficial, the early post surgery introduction of beta-blockers and ACE inhibitors should be cautious in patients with severe low LVEF, low blood pressure, and with pulmonary diseases.
On the other hand, occurrence of HF after CABG surgery is not uncommon. Perioperative myocardial injury, pre-existing left ventricular systolic dysfunction, and stunning due to reperfusion injury all can contribute to heart failure post CABG. The clinical suspicion of graft failure should be raised in the patient with signs of low cardiac output syndrome, ventricular arrhythmia, or hemodynamic instability with additional alterations of electrocardiogram (EKG) and increase of creatine kinase MB (CKMB) or troponin. Early intervention after detecting the graft failure by angiography should be done to limit the development of large myocardial injury and prevent the development of severe myocardial pump failure. In the non-graft-related HF post surgery, there are several other factors that need to be addressed, including reperfusion injury, perioperative complication, kidney injury, cardiac arrhythmia, infection, and post cardiotomy syndrome.
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References
Magro M, Garg S, Serruys PW. Revascularization treatment of stable coronary artery disease. Expert Opin Pharmacother. 2011;12(2):195–212.
Roger VL. Epidemiology of heart failure. Circ Res. 2013;113(6):646–59.
Hannan EL, Zhong Y, Lahey SJ, Culliford AT, Gold JP, Smith CR, et al. 30-day readmissions after coronary artery bypass graft surgery in new york state. JACC Cardiovasc Interv. 2011;4(5):569–76.
Holmes Jr DR, Kim LJ, Brooks MM, Kip KE, Schaff HV, Detre KM, et al. The effect of coronary artery bypass grafting on specific causes of long-term mortality in the bypass angioplasty revascularization investigation. J Thorac Cardiovasc Surg. 2007;134(1):38–46, 46 e31.
Hannan EL, Racz MJ, Walford G, Ryan TJ, Isom OW, Bennett E, et al. Predictors of readmission for complications of coronary artery bypass graft surgery. JAMA. 2003;290(6):773–80.
Alderman EL, Fisher LD, Litwin P, Kaiser GC, Myers WO, Maynard C, et al. Results of coronary artery surgery in patients with poor left ventricular function (cass). Circulation. 1983;68(4):785–95.
Passamani E, Davis KB, Gillespie MJ, Killip T. A randomized trial of coronary artery bypass surgery. Survival of patients with a low ejection fraction. N Engl J Med. 1985;312(26):1665–71.
Topkara VK, Cheema FH, Kesavaramanujam S, Mercando ML, Cheema AF, Namerow PB, et al. Coronary artery bypass grafting in patients with low ejection fraction. Circulation. 2005;112(9 Suppl):I344–50.
Basiladze L, Prangishvili A, Chapidze G, Pirvelashvili E, Bakhutashvili Z. Coronary artery bypass grafting in patients with low ejection fraction. Georgian Med News. 2009;176:17–21.
Moreyra AE, Deng Y, Wilson AC, Cosgrove NM, Kostis WJ, Kostis JB. Incidence and trends of heart failure admissions after coronary artery bypass grafting surgery. Eur J Heart Fail. 2012;15(1):46–53.
McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bohm M, Dickstein K, et al. Esc guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the european society of cardiology. Developed in collaboration with the heart failure association (hfa) of the esc. Eur Heart J. 2012;33(14):1787–847.
Yancy CW, Jessup M, Bozkurt B, Butler J, Casey Jr DE, Drazner MH, et al. 2013 accf/aha guideline for the management of heart failure: a report of the american college of cardiology foundation/american heart association task force on practice guidelines. Circulation. 2013;128(16):e240–327.
Fonseca C. Diagnosis of heart failure in primary care. Heart Fail Rev. 2006;11(2):95–107.
Kelder JC, Cramer MJ, van Wijngaarden J, van Tooren R, Mosterd A, Moons KG, et al. The diagnostic value of physical examination and additional testing in primary care patients with suspected heart failure. Circulation. 2011;124(25):2865–73.
Marui A, Kimura T, Nishiwaki N, Mitsudo K, Komiya T, Hanyu M, et al. Comparison of five-year outcomes of coronary artery bypass grafting versus percutaneous coronary intervention in patients with left ventricular ejection fractions ≤50% versus >50% (from the CREDO-Kyoto PCI/CABG Registry Cohort-2). Am J Cardiol. 2014;114(7):988–96.
Kunadian V, Pugh A, Zaman AG, Qiu W. Percutaneous coronary intervention among patients with left ventricular systolic dysfunction: a review and meta-analysis of 19 clinical studies. Coron Artery Dis. 2012;23(7):469–79.
Deb S, Wijeysundera HC, Ko DT, Tsubota H, Hill S, Fremes SE. Coronary artery bypass graft surgery vs percutaneous interventions in coronary revascularization: a systematic review. JAMA. 2013;310(19):2086–95.
Ferguson Jr TB, Coombs LP, Peterson ED. Preoperative beta-blocker use and mortality and morbidity following cabg surgery in north america. JAMA. 2002;287(17):2221–7.
Mangano DT, Layug EL, Wallace A, Tateo I. Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. Multicenter study of perioperative ischemia research group. N Engl J Med. 1996;335(23):1713–20.
Wallace A, Layug B, Tateo I, Li J, Hollenberg M, Browner W, et al. Prophylactic atenolol reduces postoperative myocardial ischemia. Mcspi research group. Anesthesiology. 1998;88(1):7–17.
Ali IM, Sanalla AA, Clark V. Beta-blocker effects on postoperative atrial fibrillation. Eur J Cardiothorac Surg. 1997;11(6):1154–7.
Braunwald E, Domanski MJ, Fowler SE, Geller NL, Gersh BJ, Hsia J, et al. Angiotensin-converting-enzyme inhibition in stable coronary artery disease. N Engl J Med. 2004;351(20):2058–68.
Dzau VJ. Mechanism of protective effects of ace inhibition on coronary artery disease. Eur Heart J. 1998;19 Suppl J:J2–6.
Oosterga M, Voors AA, Pinto YM, Buikema H, Grandjean JG, Kingma JH, et al. Effects of quinapril on clinical outcome after coronary artery bypass grafting (the quo vadis study). Quinapril on vascular ace and determinants of ischemia. Am J Cardiol. 2001;87(5):542–6.
Rouleau JL, Warnica WJ, Baillot R, Block PJ, Chocron S, Johnstone D, et al. Effects of angiotensin-converting enzyme inhibition in low-risk patients early after coronary artery bypass surgery. Circulation. 2008;117(1):24–31.
Zhang Y, Ma L. Effect of preoperative angiotensin-converting enzyme inhibitor on the outcome of coronary artery bypass graft surgery. Eur J Cardiothorac Surg. 2015;47(5):788–95.
Bottcher M, Behrens JK, Moller EA, Christensen JH, Andreasen F. Ace inhibitor premedication attenuates sympathetic responses during surgery. Br J Anaesth. 1994;72(6):633–7.
Jain U, Laflamme CJ, Aggarwal A, Ramsay JG, Comunale ME, Ghoshal S, et al. Electrocardiographic and hemodynamic changes and their association with myocardial infarction during coronary artery bypass surgery. A multicenter study. Multicenter study of perioperative ischemia (mcspi) research group. Anesthesiology. 1997;86(3):576–91.
Bybee KA, Powell BD, Valeti U, Rosales AG, Kopecky SL, Mullany C, et al. Preoperative aspirin therapy is associated with improved postoperative outcomes in patients undergoing coronary artery bypass grafting. Circulation. 2005;112(9 Suppl):I286–92.
Hongo RH, Ley J, Dick SE, Yee RR. The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting. J Am Coll Cardiol. 2002;40(2):231–7.
Mangano DT. Aspirin and mortality from coronary bypass surgery. N Engl J Med. 2002;347(17):1309–17.
Sharma GV, Khuri SF, Josa M, Folland ED, Parisi AF. The effect of antiplatelet therapy on saphenous vein coronary artery bypass graft patency. Circulation. 1983;68(3 Pt 2):II218–21.
Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003;348(14):1309–21.
Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Perez A, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized aldactone evaluation study investigators. N Engl J Med. 1999;341(10):709–17.
Packer M. The search for the ideal positive inotropic agent. N Engl J Med. 1993;329(3):201–2.
De Hert SG, Lorsomradee S, Cromheecke S, Van der Linden PJ. The effects of levosimendan in cardiac surgery patients with poor left ventricular function. Anesth Analg. 2007;104(4):766–73.
Lorusso R, Gelsomino S, Carella R, Livi U, Mariscalco G, Onorati F, et al. Impact of prophylactic intra-aortic balloon counter-pulsation on postoperative outcome in high-risk cardiac surgery patients: a multicentre, propensity-score analysis. Eur J Cardiothorac Surg. 2010;38(5):585–91.
Tritapepe L, De Santis V, Vitale D, Santulli M, Morelli A, Nofroni I, et al. Preconditioning effects of levosimendan in coronary artery bypass grafting–a pilot study. Br J Anaesth. 2006;96(6):694–700.
Eris C, Yavuz S, Toktas F, Turk T, Gucu A, Erdolu B, et al. Preoperative usages of levosimendan in patients undergoing coronary artery bypass grafting. Int J Clin Exp Med. 2014;7(1):219–29.
Cleland JG, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med. 2005;352(15):1539–49.
Goscinska-Bis K, Bis J, Krejca M, Ulczok R, Szmagala P, Bochenek A, et al. Totally epicardial cardiac resynchronization therapy system implantation in patients with heart failure undergoing cabg. Eur J Heart Fail. 2008;10(5):498–506.
Force T, Hibberd P, Weeks G, Kemper AJ, Bloomfield P, Tow D, et al. Perioperative myocardial infarction after coronary artery bypass surgery. Clinical significance and approach to risk stratification. Circulation. 1990;82(3):903–12.
Thielmann M, Massoudy P, Schmermund A, Neuhauser M, Marggraf G, Kamler M, et al. Diagnostic discrimination between graft-related and non-graft-related perioperative myocardial infarction with cardiac troponin i after coronary artery bypass surgery. Eur Heart J. 2005;26(22):2440–7.
Thielmann M, Massoudy P, Jaeger BR, Neuhauser M, Marggraf G, Sack S, et al. Emergency re-revascularization with percutaneous coronary intervention, reoperation, or conservative treatment in patients with acute perioperative graft failure following coronary artery bypass surgery. Eur J Cardiothorac Surg. 2006;30(1):117–25.
Holmvang L, Jurlander B, Rasmussen C, Thiis JJ, Grande P, Clemmensen P. Use of biochemical markers of infarction for diagnosing perioperative myocardial infarction and early graft occlusion after coronary artery bypass surgery. Chest. 2002;121(1):103–11.
Raabe Jr DS, Morise A, Sbarbaro JA, Gundel WD. Diagnostic criteria for acute myocardial infarction in patients undergoing coronary artery bypass surgery. Circulation. 1980;62(4):869–78.
D’Ancona G, Karamanoukian HL, Soltoski P, Salerno TA, Bergsland J. Changing referral pattern in off-pump coronary artery bypass surgery: a strategy for improving surgical results. Heart Surg Forum. 1999;2(3):246–9.
Laflamme M, DeMey N, Bouchard D, Carrier M, Demers P, Pellerin M, et al. Management of early postoperative coronary artery bypass graft failure. Interact Cardiovasc Thorac Surg. 2012;14(4):452–6.
Rasmussen C, Thiis JJ, Clemmensen P, Efsen F, Arendrup HC, Saunamaki K, et al. Significance and management of early graft failure after coronary artery bypass grafting: feasibility and results of acute angiography and re-re-vascularization. Eur J Cardiothorac Surg. 1997;12(6):847–52.
Theologou T, Bashir M, Rengarajan A, Khan O, Spyt T, Richens D, et al. Preoperative intra aortic balloon pumps in patients undergoing coronary artery bypass grafting. Cochrane Database Syst Rev. 2011(1):CD004472.
Turer AT, Hill JA. Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy. Am J Cardiol. 2010;106(3):360–8.
Mentzer Jr RM. Myocardial protection in heart surgery. J Cardiovasc Pharmacol Ther. 2011;16(3–4):290–7.
Carvalho G, Pelletier P, Albacker T, Lachapelle K, Joanisse DR, Hatzakorzian R, et al. Cardioprotective effects of glucose and insulin administration while maintaining normoglycemia (gin therapy) in patients undergoing coronary artery bypass grafting. J Clin Endocrinol Metab. 2011;96(5):1469–77.
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Hartono, B., Munawar, D.A., Munawar, M. (2016). Management of Heart Failure After CABG. In: Ţintoiu, I., Underwood, M., Cook, S., Kitabata, H., Abbas, A. (eds) Coronary Graft Failure. Springer, Cham. https://doi.org/10.1007/978-3-319-26515-5_53
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