Abstract
While there is converging evidence suggesting gender differences in the rates of suicidal behaviors, substantially less is known about the mechanisms underlying these differences. What follows is a review of the evidence supporting gender differences in suicidal behaviors, including epidemiology, age trends, methods, risk and protective factors, treatment, and the effects of sexual orientation and culture.
Although some of the gender differences in suicidal behaviors may be partially explained by environmental and behavioral factors, there is very little data on the role of sex differences in neurobiological risk factors. Surprisingly, the role of sexual hormones and sex differences in brain development on the risk for suicidal behaviors remains largely unexplored.
Alfredo Gutierrez and Alison Welch are contributed equally to this work.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Accortt EE, Freeman MP, Allen JJB (2008) Women and major depressive disorder: clinical perspectives on causal pathways. J Womens Health 17(10):1583–1590. doi:10.1089/jwh.2007.0592
Afifi TO, Enns MW, Cox BJ, Asmundson GJ, Stein MB, Sareen J (2008) Population attributable fractions of psychiatric disorders and suicide ideation and attempts associated with adverse childhood experiences. Am J Public Health 98(5):946–952. doi:10.2105/ajph.2007.120253
Andersson L, Sundstr¨om-Poromaa I, Bixo M, Wulff M, Bondestam K, Astr¨om M (2003) Point prevalence of psychiatric disorders during the second trimester of pregnancy: a population-based study. Am J Obstet Gynecol 189(1):148–154
Angold A, Costello JE (2006) Puberty and depression. Child Adolesc Psychiatr Clin N Am 15:919–937
APA (1994) Diagnostic and statistical manual of mental disorders: DSM-IV, 4th edn. American Psychiatric Association, Washington, DC
APA (2003) Practice guideline for the assessment and treatment of patients with suicidal behaviors. Am J Psychiatry 160(11 Suppl):1–60
APA (2013) Diagnostic and statistical manual of mental disorders: DSM-5. American Psychiatric Association, Washington, DC
Arlt W (2006) Androgen therapy in women. Eur J Endocrinol 154:1–11
Arsenault-Lapierre G, Kim C, Turecki G (2004) Psychiatric diagnoses in 3275 suicides a meta-analysis. BMC Psychiatry 4(37):1–11. doi:10.1186/1471-244X-4-37
Baca-Garcia E, Dias-Sastre C, Ceverino A, Saiz-Ruiz J, Diaz FJ, De Leon J (2003) Association between the menses and suicide attempts: a replication study. Psychosom Med 65(2):237–244
Baca-Garcia E, Diaz-Sastre C, Ceverino A et al (2004) Premenstrual symptoms and luteal suicide attempts. Eur Arch Psychiatry Clin Neurosci 254(5):326–329
Baca-Garcia E, Perez-Rodriguez MM, Mann JJ, Oquendo MA (2008) Suicidal behavior in young women. Psychiatr Clin N Am 31(2):317–331, S0193-953X(08)00015-4 [pii]
Baca-Garcia E, Perez-Rodriguez MM, Keyes KM, Oquendo MA, Hasin DS, Grant BF, Blanco C (2010) Suicidal ideation and suicide attempts in the United States: 1991–1992 and 2001–2002. Mol Psychiatry 15(3):250–259. doi:10.1038/mp.2008.98, mp200898 [pii]
Baca-Garcia E, Perez-Rodriguez MM, Keyes KM, Oquendo MA, Hasin DS, Grant BF, Blanco C (2011) Suicidal ideation and suicide attempts among Hispanic subgroups in the United States: 1991–1992 and 2001–2002. J Psychiatr Res 45(4):512–518. doi:10.1016/j.jpsychires.2010.09.004
Barrett-Connor E, Von Mühlen DG, Kritz-Silverstein D (1999) Bioavailable testosterone and depressed mood in older men: the Rancho Bernardo Study. J Clin Endocrinol Metab 84:573–577
Bennett HA, Einarson A, Taddio A et al (2004) Prevalence of depression during pregnancy: systematic review. Obstet Gynecol 103:698–709
Blasco-Fontecilla H, Baca-Garcia E, Dervic K, Perez-Rodriguez MM, Saiz-Gonzalez MD, Saiz-Ruiz J, Oquendo MA, de Leon J (2009) Severity of personality disorders and suicide attempt. Acta Psychiatr Scand 119(2):149–155. doi:10.1111/j.1600-0447.2008.01284.x, ACP1284 [pii]
Blasco-Fontecilla H, Perez-Rodriguez MM, Garcia-Nieto R, Fernandez-Navarro P, Galfalvy H, de Leon J, Baca-Garcia E (2012) Worldwide impact of economic cycles on suicide trends over 3 decades: differences according to level of development. A mixed effect model study. BMJ Open 2(3). doi:10.1136/bmjopen-2011-000785
Block M, Schmidt PJ, Danaceau M et al (2000) Effects of gonadal steroids in women with a history of postpartum depression. Am J Psychiatry 157:924–930
Boldrini M, Underwood MD, Mann JJ, Arango V (2008) Serotonin-1A autoreceptor binding in the dorsal raphe nucleus of depressed suicides. J Psychiatr Res 42(6):433–442. doi:10.1016/j.jpsychires.2007.05.004
Borowsky SJ, Rubenstein LV, Meredith LS, Camp P, Jackson-Triche MM, Wells KB (2000) Who is at risk of nondetection of mental health problems in primary care? J Gen Intern Med 15:381–388. doi:10.1046/j.1525-1497.2000.12088.x
Brent DA (1995) Risk factors for adolescent suicide and suicidal behavior: mental and substance abuse disorders, family environmental factors, and life stress. Suicide Life Threat Behav 25:52–63. doi:10.1111/j.1943-278X.1995.tb00490.x
Brent DA, Baugher M, Bridge J, Chen T, Chiappetta L (1999) Age- and sex-related risk factors for adolescent suicide. J Am Acad Child Adolesc Psychiatry 38(12):1497–1505. doi:10.1097/00004583-199912000-00010
Brower KJ, Blow FC, Eliopulos GA, Beresford TP (1989) Anabolic androgenic steroids and suicide. Am J Psychiatry 146:1075
Butterfield MI, Stechuchak KM, Connor KM, Davidson JR, Wang C et al (2005) Neuroactive steroids and suicidality in posttraumatic stress disorder. Am J Psychiatry 162:380–382
Canetto SS, Sakinofsky I (1998) The gender paradox in suicide. Suicide Life Threat Behav 28(1):1–23
Carrier N, Kabbaj M (2012a) Extracellular signal-regulated kinase 2 signaling in the hippocampal dentate gyrus mediates the antidepressant effects of testosterone. Biol Psychiatry 71:642–651
Carrier N, Kabbaj M (2012b) Testosterone and imipramine have antidepressant effects in socially isolated male but not female rats. Horm Behav 61:678–685
Centers for Disease Control and Prevention (2012) Suicide: facts at a glance. Available at: http://www.cdc.gov/violenceprevention/pdf/suicide-datasheet-a.pdf. Accessed 1 Oct 2014
Centers for Disease Control and Prevention. Web-based Injury Statistics Query and Reporting System. Available at: http://www.cdc.gov/injury/wisqars/index.html. Accessed 1 Oct 2014
Chu LW, Tam S, Wong RL, Yik PY, Song Y et al (2010) Bioavailable testosterone predicts a lower risk of Alzheimer’s disease in older men. J Alzheimers Dis 21:1335–1345
da Silva R, da Costa Ores L, Jansen K et al (2012) Suicidality and associated factors in pregnant women in Brazil. Community Ment Health J 48(3):392–395
Denning DG, Conwell Y, King D, Cox C (2000) Method choice, intent, and gender in completed suicide. Suicide Life Threat Behav 30(3):282–288
Diaz-Sastre C, Baca-Garcia E, Perez-Rodriguez MM, Garcia-Resa E, Ceverino A, Saiz-Ruiz J, Oquendo MA, de Leon J (2007) Low plasma cholesterol levels in suicidal males: a gender- and body mass index-matched case-control study of suicide attempters and nonattempters. Prog Neuropsychopharmacol Biol Psychiatry 31(4):901–905. doi:10.1016/j.pnpbp.2007.02.004, S0278-5846(07)00063-2 [pii]
Eaton NR, Keyes KM, Krueger RF, Balsis S, Skodol AE, Markon KE, Grant BF, Hasin DS (2012) An invariant dimensional liability model of gender differences in mental disorder prevalence: evidence from a national sample. J Abnorm Psychol 121(1):282–288. doi:10.1037/a0024780
Ebinger M, Sievers C, Ivan D, Schneider HJ, Stalla GK (2009) Is there a neuroendocrinological rationale for testosterone as a therapeutic option in depression? J Psychopharmacol 23:841–853
Ehrenkranz J, Bliss E, Sheard MH (1974) Plasma testosterone: correlation with aggressive behavior and social dominance in man. Psychosom Med 36:469–475
Eisenberg D, Golberstein E, Gollust SE (2007) Help-seeking and access to mental health care in a university student population. Med Care 45(7):594–601. doi:10.1097/MLR.0b013e31803bb4c1
Ellis JB, Lamis DA (2007) Adaptive characteristics and suicidal behavior: a gender comparison of young adults. Death Stud 31(9):845–854. doi:10.1080/07481180701537303
Fairburn CG, Harrison PJ (2003) Eating disorders. Lancet 361:407–416
Favaro A, Santonastaso P (1997) Suicidality in eating disorders: clinical and psychological correlates. Acta Psychiatr Scand 95:508–514. doi:10.1111/j.1600-0447.1997.tb10139.x
Field T, Hernandez-Reif M, Diego M (2006) Risk factors and stress variables that differentiate depressed from nondepressed pregnant women. Infant Behav Dev 29:169–174
Fink G, Sumner B, McQueen J, Wilson H, Rosie R (1998) Sex steroid control of mood, mental state and memory. Clin Exp Pharmacol Physiol 25:764–775
Fiori LM, Zouk H, Himmelman C, Turecki G (2011) X chromosome and suicide. Mol Psychiatry 16(2):216–226. doi:10.1038/mp.2009.132
Frautschi S, Cerulli A, Maine D (1994) Suicide during pregnancy and its neglect as a component of maternal mortality. Int J Gynecol Obstet 47(3):275–284
Freedman MA (2002) Quality of life and menopause: the role of estrogen. J Womens Health (Larchmt) 11:703–718
Frye CA, Walf AA (2009) Depression-like behavior of aged male and female mice is ameliorated with administration of testosterone or its metabolites. Physiol Behav 97:266–269
Genazzani AR, Monteleone P, Gambacciani M (2002) Hormonal influence on the central nervous system. Maturitas 43:S11–S17
General OotS (2012) Office of the Surgeon General (US); National Action Alliance for Suicide Prevention (US). 2012 National Strategy for Suicide Prevention: Goals and Objectives for Action: A Report of the U.S. Surgeon General and of the National Action Alliance for Suicide Prevention. Washington (DC): US Department of Health & Human Services (US); Available from: http://www.ncbi.nlm.nih.gov/books/NBK109917/
Giner L, Blasco-Fontecilla H, Perez-Rodriguez MM, Garcia-Nieto R, Giner J, Guija JA, Rico A, Barrero E, Luna MA, De Leon J, Oquendo MA, Baca-Garcia E (2013) Personality disorders and health problems distinguish suicide attempters from completers in a direct comparison. J Affect Disord 151:474–483. doi:10.1016/j.jad.2013.06.029
Gissler M, Hemminki E, L¨onnqvist J (1996) Suicides after pregnancy in Finland, 1987–94: register linkage study. Br Med J 313(7070):1431–1434
Grant BF, Chou SP, Goldstein RB, Huang B, Stinson FS, Saha TD, Smith SM, Dawson DA, Pulay AJ, Pickering RP, Ruan WJ (2008) Prevalence, correlates, disability, and comorbidity of DSM-IV borderline personality disorder: results from the Wave 2 National Epidemiologic Survey on Alcohol and Related Conditions. J Clin Psychiatry 69(4):533–545, doi:ej07m03916 [pii]
Harris EC, Barraclough B (1997) Suicide as an outcome for mental disorders; a meta-analysis. Br J Psychiatry 170:205–228. doi:10.1192/bjp.170.3.205
Hawton K, Harriss L (2008) The changing gender ratio in occurrence of deliberate self-harm across the lifecycle. Crisis 29(1):4–108
Hawton K, van Heeringen K (2009) Suicide. Lancet 373(9672):1372–1381. doi:10.1016/S0140-6736(09)60372-X, S0140-6736(09)60372-X [pii]
Hoyer G, Lund E (1993) Suicide among women related to number of children in marriage. Arch Gen Psychiatry 50(2):134–137
Hunt IM, Robinson J, Bickley H, Meehan J, Parsons R, Mccann K, Flynn S, Burns J, Shaw J, Kapur N, Appleby L (2003) Suicides in ethnic minorities within 12 months of contact with mental health services: national clinical survey. Br J Psychiatry 183(2):155–160. doi:10.1192/bjp.02.323
Kelly E, Sharma V (2010) Diagnosis and treatment of postpartum bipolar depression. Expert Rev Neurother 10:1045–1051
Kessler RC, Borges G, Walters EE (1999) Prevalence of and risk factors for lifetime suicide attempts in the National Comorbidity Survey. Arch Gen Psychiatry 56(7):617–626
Kessler RC, Berglund P, Borges G, Nock M, Wang PS (2005) Trends in suicide ideation, plans, gestures, and attempts in the United States, 1990–1992 to 2001–2003. JAMA 293(20):2487–2495. doi:10.1001/jama.293.20.2487, 293/20/2487 [pii]
King M, Semlyen J, Tai SS, Killaspy H, Osborn D, Popelyuk D, Nazareth I (2008) A systematic review of mental disorder, suicide, and deliberate self harm in lesbian, gay and bisexual people. BMC Psychiatry 8:70. doi:10.1186/1471-244x-8-70
Kposowa AJ, McElvain JP (2006) Gender, place, and method of suicide. Soc Psychiatry Psychiatr Epidemiol 41:435–443. doi:10.1007/s00127-006-0054-2
Kullgren G (1988) Factors associated with completed suicide in borderline personality disorder. J Nerv Ment Dis 176(1):40–44. doi:10.1097/00005053-198801000-00005
Lalovic A, Merkens L, Russell L, Arsenault-Lapierre G, Nowaczyk MJ, Porter FD et al (2004) Cholesterol metabolism and suicidality in Smith-Lemli-Opitz syndrome carriers. Am J Psychiatry 161:2123–2126, PubMed: 15514417
Lesage AD, Boyer R, Grunberg F, Vanier C, Morissette R, Menard-Buteau C, Loyer M (1994) Suicide and mental disorders: a case-control study of young men. Am J Psychiatry 151(7):1063–1068
Linehan MM, Goodstein JL, Nielsen SL, Chiles JA (1983) Reasons for staying alive when you are thinking of killing yourself: the reasons for living inventory. J Consult Clin Psychol 51(2):276–286
Lizardi D, Currier D, Galfalvy H, Sher L, Burke A, Mann J, Oquendo M (2007) Perceived reasons for living at index hospitalization and future suicide attempt. J Nerv Ment Dis 195(5):451–455. doi:10.1097/NMD.0b013e3180522661, 00005053-200705000-00013 [pii]
Luoma JB, Pearson JL (2002) Suicide and marital status in the United States, 1991–1996: is widowhood a risk factor? Am J Public Health 92(9):1518–1522
Mackenzie CS, Gekoski WL, Knox VJ (2006) Age, gender, and the underutilization of mental health services: the influence of help-seeking attitudes. Aging Ment Health 10(6):574–582. doi:10.1080/13607860600641200
Mann JJ, Waternaux C, Haas GL, Malone KM (1999) Toward a clinical model of suicidal behavior in psychiatric patients. Am J Psychiatry 156(2):181–189
Markianos M, Tripodianakis J, Istikoglou C, Rouvali O, Christopoulos M et al (2009) Suicide attempt by jumping: a study of gonadal axis hormones in male suicide attempters versus men who fell by accident. Psychiatry Res 170:82–85
Marshall MP, Dietz LJ, Friedman MS, Stall R, Smith HA, McGinley J, Thoma BC, Murray PJ, D’Augelli AR, Brent DA (2011) Suicidality and depression disparities between sexual minority and heterosexual youth: a meta-analytic review. J Adolesc Health 49:115–123. doi:10.1016/j.jadohealth.2011.02.005
Mathews DC, Richards EM, Niciu MJ, Ionescu DF, Rasimas JJ, Zarate CA Jr (2013) Neurobiological aspects of suicide and suicide attempts in bipolar disorder. Transl Neurosci 4(2):2013–2016. doi:10.2478/s13380-013-0120-7
Mattsson A, Schalling D, Olweus D, Löw H, Svensson J (1980) Plasma testosterone, aggressive behavior, and personality dimensions in young male delinquents. J Am Acad Child Adolesc Psychiatry 19:476–490
Mauch DH, Nagler K, Schumacher S, Goritz C, Muller EC, Otto A et al (2001) CNS synaptogenesis promoted by glia-derived cholesterol. Science 294:1354–1357
McGirr A, Seguin M, Renaud J, Benkelfat C, Alda M, Turecki G (2006) Gender and risk factors for suicide: evidence for heterogeneity in predisposing mechanisms in a psychological autopsy study. J Clin Psychiatry 67:1612–1617. doi:10.4088/jcp.v67n1018
Melville JL, Gavin A, Guo Y, Fan MY, Katon WJ (2010) Depressive disorders during pregnancy: prevalence and risk factors in a large urban sample. Obstet Gynecol 116(5):1064–1070
Mendez-Bustos P, Lopez-Castroman J, Baca-GarcÃa E, Ceverino A (2013) Life cycle and suicidal behavior among women. Sci World J. doi:10.1155/2013/485851, Article ID 485851:9 pages
Miotto P, De Coppi M, Frezza M, Preti A (2003) Eating disorder and suicide risk factors in adolescents: an Italian community-based study. J Nerv Ment Dis 191(7):437–443. doi:10.1097/01.nmd.0000081590.91326.8b
Molnar BE, Berkman LF, Buka SL (2001a) Psychopathology, childhood sexual abuse and other childhood adversities: relative links to subsequent suicidal behaviour in the US. Psychol Med 31(6):965–977
Molnar BE, Buka SL, Kessler RC (2001b) Child sexual abuse and subsequent psychopathology: results from the National Comorbidity Survey. Am J Public Health 91(5):753–760
Moscicki EK (1994) Gender differences in completed and attempted suicides. Ann Epidemiol 4:152–158. doi:10.1016/1047-2797(94)90062-0
Nock MK, Kessler RC (2006) Prevalence of and risk factors for suicide attempts versus suicide gestures: analysis of the National Comorbidity Survey. J Abnorm Psychol 115(3):616–623. doi:10.1037/0021-843x.115.3.616
Nordentoft M (2011) Absolute risk of suicide after first hospital contact in mental disorder. Arch Gen Psychiatry 68(10):1058–1064. doi:10.1001/archgenpsychiatry.2011.113
Oquendo MA, Ellis SP, Greenwald S, Malone KM, Weissman MM, Mann JJ (2001) Ethnic and sex differences in suicide rates relative to major depression in the United States. Am J Psychiatry 158(10):1652–1658
Oquendo MA, Dragatsi D, Harkavy-Friedman J, Dervic K, Currier D, Burke AK, Grunebaum MF, Mann JJ (2005) Protective factors against suicidal behavior in Latinos. J Nerv Ment Dis 193(7):438–443, 00005053-200507000-00002 [pii]
Oquendo MA, Bongiovi-Garcia ME, Galfalvy H, Goldberg PH, Grunebaum MF, Burke AK, Mann JJ (2007) Sex differences in clinical predictors of suicidal acts after major depression: a prospective study. Am J Psychiatry 164(1):134–141. doi:10.1176/appi.ajp.164.1.134
Oquendo MA, Perez-Rodriguez MM, Poh E, Sullivan G, Burke AK, Sublette ME, Mann JJ, Galfalvy H (2014) Life events: a complex role in the timing of suicidal behavior among depressed patients. Mol Psychiatry 19(8):902–909. doi:10.1038/mp.2013.128
Pandey GN (2013) Biological basis of suicide and suicidal behavior. Bipolar Disord 15(5):524–541. doi:10.1111/bdi.12089
Parsey RV, Oquendo MA, Simpson NR, Ogden RT, Van Heertum R, Arango V, Mann JJ (2002) Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635. Brain Res 954(2):173–182
Perez-Rodriguez MM, Baca-Garcia E, Diaz-Sastre C, Garcia-Resa E, Ceverino A, Saiz-Ruiz J, Oquendo MA, de Leon J (2008a) Low serum cholesterol may be associated with suicide attempt history. J Clin Psychiatry 69(12):1920–1927, ej07m03866 [pii]
Perez-Rodriguez MM, Baca-Garcia E, Oquendo MA, Blanco C (2008b) Ethnic differences in suicidal ideation and attempts. Prim Psychiatry 15(2):44–53
Perez-Rodriguez MM, Lopez-Castroman J, Martinez-Vigo M, Diaz-Sastre C, Ceverino A et al (2011) Lack of association between testosterone and suicide attempts. Neuropsychobiology 63:125–130
Perez-Rodriguez MM, Baca-Garcia E, Oquendo MA, Wang S, Wall MM, Liu SM, Blanco C (2014) Relationship between acculturation, discrimination, and suicidal ideation and attempts among US Hispanics in the National Epidemiologic Survey of Alcohol and Related Conditions. J Clin Psychiatry 75(4):399–407. doi:10.4088/JCP.13m08548
Pinheiro RT et al (2012) Brain-derived neurotrophic factor levels in women with postpartum affective disorder and suicidality. Neurochem Res 37:2229–2234
Pitman A, Krysinska K, Osborn D, King M (2012) Suicide in young men. Lancet 379(9834):2383–2392. doi:10.1016/s0140-6736(12)60731-4
Pompili M, Girardi P, Ruberto A, Tatarelli R (2005) Suicide in borderline personality disorder: a meta-analysis. Nord J Psychiatry 59(5):319–324. doi:10.1080/08039480500320025
Pope HG Jr, Katz DL (1994) Psychiatric and medical effects of anabolic androgenic steroid use. A controlled study of 160 athletes. Arch Gen Psychiatry 51:375–382
Pope HG Jr, Katz DL (1998) Affective and psychotic symptoms associated with anabolic steroid use. Am J Psychiatry 145:487–490
Pope HG Jr, Kouri EM, Hudson JI (2000) Effects of supraphysiologic doses of testosterone on mood and aggression in normal men: a randomized controlled trial. Arch Gen Psychiatry 57:133–140
Preti A, Rocchi MBL, Sisti D, Camboni MV, Miotto P (2011) A comprehensive meta-analysis of the risk of suicide in eating disorders. Acta Psychiatr Scand 124:6–17. doi:10.1111/j.1600-0447.2010.01641.x
Qin P, Mortensen PB (2003) The impact of parental status on the risk of completed suicide. Arch Gen Psychiatry 60(8):797–802. doi:10.1001/archpsyc.60.8.797
Qin P, Agerbo E, Westergard-Nielsen N, Eriksson T, Mortensen PB (2000) Gender differences in risk factors for suicide in Denmark. Br J Psychiatry 177:546–550
Reck C, Struben K, Backenstrass M et al (2008) Prevalence, onset and comorbidity of postpartum anxiety and depressive disorders. Acta Psychiatr Scand 118(6):459–468
Remafedi G, French S, Story M, Resnick MD, Blum R (1998) The relationship between suicide risk and sexual orientation: results of a population-based study. Am J Publ Health 88(1):57–60. doi:10.2105/ajph.88.1.57
Ringo DL, Lindley SE, Faull KF, Faustman WO (1994) Cholesterol and serotonin: seeking a possible link between blood cholesterol and CSF 5-HIAA. Biol Psychiatry 35:957–959
Russel ST, Toomey RB (2012) Men’s sexual orientation and suicide: evidence for U.S. adolescent-specific risk. Soc Sci Med 74:523–529. doi:10.1016/j.socscimed.2010.07.038
Russell ST, Joyner K (2001) Adolescent sexual orientation and suicide risk: evidence from a national study. Am J Publ Health 91(8):1276–1281. doi:10.2105/ajph.91.8.1276
Saunders KEA, Hawton K (2006) Suicidal behaviour and the mentstrual cycle. Psychol Med 36(7):901–912
Seidman SN, Walsh BT (1999) Testosterone and depression in aging men. Am J Geriatr Psychiatry 7:18–33
Sher L (2012) Testosterone and suicidal behavior. Expert Rev Neurother 12:25–29
Sher L (2013) Low testosterone levels may be associated with suicidal behavior in older men while high testosterone levels may be related to suicidal behavior in adolescents and young adults: a hypothesis. Int J Adolesc Med Health 25(3):263–268. doi:10.1515/ijamh-2013-0060
Sher L, Grunebaum MF, Sullivan GM, Burke AK, Cooper TB et al (2012) Testosterone levels in suicide attempters with bipolar disorder. J Psychiatr Res 46:1267–1271
Sher L, Grunebaum MF, Sullivan GM, Burke AK, Cooper TB, Mann JJ, Oquendo MA (2014) Association of testosterone levels and future suicide attempts in females with bipolar disorder. J Affect Disord 166:98–102
Soares CN, Zitek B (2008) Reproductive hormone sensitivity and risk for depression across the female life cycle: a continuum of vulnerability? J Psychiatry Neurosci 33(4):331–343
Soler H, Vinayak P, Quadagno D (2000) Biosocial aspects of domestic violence. Psychoneuroendocrinology 25:721–739
Soloff PH, Price JC, Mason NS, Becker C, Meltzer CC (2010) Gender, personality, and serotonin-2A receptor binding in healthy subjects. Psychiatry Res 181(1):77–84. doi:10.1016/j.pscychresns.2009.08.007
Soules MR, Sherman S, Parrott E et al (2001) Executive summary: Stages of Reproductive Aging Workshop (STRAW). Fertil Steril 76:874–878
Spokas M, Wenzel A, Stirman SW, Brown GK, Beck AT (2009) Suicide risk factors and mediators between childhood sexual abuse and suicide ideation among male and female suicide attempters. J Trauma Stress 22(5):467–470. doi:10.1002/jts.20438
Sprock J, Yoder CY (1997) Women and depression: an update on the report of the APA task force. Sex Roles 36:269–303
Su TP, Pagliaro M, Schmidt PJ, Pickar D, Wolkowitz O et al (1993) Neuropsychiatric effects of anabolic steroids in male normal volunteers. J Am Med Assoc 269:2760–2764
Sumner B, Grant K, Rosie R, Hegele-Hartung C, Fritzemeier K, Fink G (1999) Effects of tamoxifen on serotonin transporter and 5–hydroxytryptamine(2A) receptor binding sites and mRNA levels in the brain of ovariectomized rats with or without acute estradiol replacement. Brain Res Mol Brain Res 73:119–128
Tanapat P, Hastings NB, Reeves AJ, Gould E (1999) Estrogen stimulates a transient increase in the number of new neurons in the dentate gyrus of the adult female rat. J Neurosci 19:5792–5801
Thilers PP, Macdonald SW, Herlitz A (2006) The association between endogenous free testosterone and cognitive performance: a population-based study in 35 to 90 year-old men and women. Psychoneuroendocrinology 31:565–576
Tonelli LH, Stiller J, Rujescu D et al (2008) Elevated cytokine expression in the orbitofrontal cortex of victims of suicide. Acta Psychiatr Scand 117:198–206
Tripodianakis J, Markianos M, Rouvali O, Istikoglou C (2007) Gonadal axis hormones in psychiatric male patients after a suicide attempt. Eur Arch Psychiatry Clin Neurosci 257:135–139
Turecki G (2014) The molecular bases of the suicidal brain. Nat Rev Neurosci. doi:10.1038/nrn3839
Willis LA, Coombs DW, Drentea P, Cockerham WC (2003) Uncovering the mystery: factors of African American suicide. Suicide Life Threat Behav 33:412–429
Winstead BA, Sanchez J (2005) Gender and psychopathology. In: Maddux JE, Winstead BA (eds) Psychopathology: foundations for a contemporary understanding. Lawrence Erlbaum Associates, Mahwah, pp 39–62
Wolk SI, Weissman MM (1995) Women and depression: an update. Rev Psychiatry 14:227–259
World Health Organization (2014) Mental health: age-standardized suicide rates (per 100 000 population, 2012. Available at: http://gamapserver.who.int/gho/interactive_charts/mental_health/suicide_rates/atlas.html. Accessed 1 Oct 2014
Wunderlich U, Bronisch T, Wittchen HU, Carter R (2001) Gender differences in adolescents and young adults with suicidal behaviour. Acta Psychiatr Scand 104(5):332–339
Zarrouf FA, Artz S, Griffith J, Sirbu C, Kommor M (2009) Testosterone and depression: systematic review and meta-analysis. J Psychiatr Pract 15:289–305
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Perez-Rodriguez, M.M., Gutierrez, A., Welch, A. (2016). The Gender Matters. In: Courtet, P. (eds) Understanding Suicide. Springer, Cham. https://doi.org/10.1007/978-3-319-26282-6_31
Download citation
DOI: https://doi.org/10.1007/978-3-319-26282-6_31
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-26280-2
Online ISBN: 978-3-319-26282-6
eBook Packages: MedicineMedicine (R0)