Abstract
This chapter addresses the treatment of pulmonary tuberculosis highlighting drug classes, recommended regimens, adverse drug reactions, drug-drug interactions, and practical aspects of monitoring, The principles of treatment of latent tuberculosis are also addressed including whom to treat, what regimens to use, and practical aspects of monitoring.
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References
Fox W, Ellard GA, Mitchison DA. Studies on the treatment of tuberculosis undertaken by the British Medical Research Council tuberculosis units, 1946–1986, with relevant subsequent publications. Int J Tuberc Lung Dis. 1999;3(10 Suppl 2):S231–79.
Iseman MD. A clinician’s guide to tuberculosis. Philadelphia: Lippincott Williams & Wilkins; 2000.
Treatment of tuberculosis: guidelines – 4th ed. Geneva, World Health Organization, 2010 (WHO/HTM/TB/2009.420).
Zumla A, Nahid P, Cole ST. Advances in the development of new tuberculosis drugs and treatment regimens. Nat Rev Drug Discov. 2013;12(5):388–404.
Blumberg HM, Burman WJ, Chaisson RE, et al. American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis. Am J Respir Crit Care Med. 2003;167(4):603–62.
Benator D, Bhattacharya M, Bozeman L, et al. Rifapentine and isoniazid once a week versus rifampicin and isoniazid twice a week for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: a randomised clinical trial. Lancet. 2002;360(9332):528–34.
Jo KW, Yoo JW, Hong Y, et al. Risk factors for 1-year relapse of pulmonary tuberculosis treated with a 6-month daily regimen. Respir Med. 2014;108(4):654–9.
Lee CH, Wang WJ, Lan RS, Tsai YH, Chiang YC. Corticosteroids in the treatment of tuberculous pleurisy. A double-blind, placebo-controlled, randomized study. Chest. 1988;94(6):1256–9.
Galarza I, Canete C, Granados A, Estopa R, Manresa F. Randomised trial of corticosteroids in the treatment of tuberculous pleurisy. Thorax. 1995;50(12):1305–7.
Wyser C, Walzl G, Smedema JP, Swart F, van Schalkwyk EM, van de Wal BW. Corticosteroids in the treatment of tuberculous pleurisy. A double-blind, placebo-controlled, randomized study. Chest. 1996;110(2):333–8.
Elliott AM, Luzze H, Quigley MA, et al. A randomized, double-blind, placebo-controlled trial of the use of prednisolone as an adjunct to treatment in HIV-1-associated pleural tuberculosis. J Infect Dis. 2004;190(5):869–78.
Mayosi BM, Ntsekhe M, Bosch J, et al. Prednisolone and Mycobacterium indicus pranii in tuberculous pericarditis. N Engl J Med. 2014;371:1121–30.
Thwaites GE, Nguyen DB, Nguyen HD, et al. Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N Engl J Med. 2004;351(17):1741–51.
Prasad K, Singh MB. Corticosteroids for managing tuberculous meningitis. Cochrane Database Syst Rev. 2008;1, CD002244.
Alsultan A, Peloquin CA. Therapeutic drug monitoring in the treatment of tuberculosis: an update. Drugs. 2014;74(8):839–54.
van Rie A, Warren R, Richardson M, et al. Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment. N Engl J Med. 1999;341(16):1174–9.
Deciding when to treat latent TB infection. Available at http://www.cdc.gov/tb/topic/treatment/decideltbi.htm. Accessed 14 June 2016.
No authors listed. Targeted tuberculin testing and treatment of latent tuberculosis infection. Joint statement of the American Thoracic Society, and the Centers for Disease Control and Prevention. Am J Respir Crit Care Med. 2000;161(4 Pt 2):S221–47.
Getahun H, Matteelli A, Abubakar I, Abdel Aziz M, Baddeley A, et al. Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries. Eur Respir J. 2015;46:1563–76.
World Health Organization. Guidelines on the management of latent tuberculosis infection. Geneva: World Health Organization; 2015 (WHO/HTM/TB/2015/01).
World Health Organization. Recommendations on 36 months isoniazid preventive therapy to adults and adolescents living with HIV in resource-constrained and high TB and HIV-prevalence settings: 2015 update. Geneva: World Health Organization; 2015 (WHO/HTM/TB/2015.15).
Centers for Disease Control and Prevention (CDC). Recommendations for use of an isoniazid-rifapentine regimen with direct observation to treat latent Mycobacterium tuberculosis infection. MMWR Morb Mortal Wkly Rep. 2011;60:1650–3.
Treatment regimens for latent TB infection (LTBI). Available at http://www.cdc.gov/tb/topic/treatment/ltbi.htm. Accessed 14 June 2016.
Horsburgh Jr CR, Rubin EJ. Latent tuberculosis infection in the United States. N Engl J Med. 2011;364:1441–8.
Akolo C, Adetifa I, Shepperd S, Volmink J. Treatment of latent tuberculosis infection in HIV infected persons. Cochrane Database Syst Rev. 2010;1, CD000171.
Centers for Disease Control and Prevention (CDC); American Thoracic Society. Update: adverse event data and revised American Thoracic Society/CDC recommendations against the use of rifampin and pyrazinamide for treatment of latent tuberculosis infection – United States, 2003. MMWR Morb Mortal Wkly Rep. 2003;52:735–9.
Sterling TR, Villarino ME, Borisov AS, Shang N, Gordin F, et al. Three months of rifapentine and isoniazid for latent tuberculosis infection. N Engl J Med. 2011;365:2155–66.
Villarino ME, et al. Treatment for preventing tuberculosis in children and adolescents. JAMA Pediatr. 2015;169(3):247–55.
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Dorman, S., Gupta, A. (2017). Treatment of Pulmonary Tuberculosis. In: Grosset, J., Chaisson, R. (eds) Handbook of Tuberculosis. Adis, Cham. https://doi.org/10.1007/978-3-319-26273-4_3
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DOI: https://doi.org/10.1007/978-3-319-26273-4_3
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