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Tracers Applied in Radioguided Surgery

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Radioguided Surgery

Abstract

Radioguided surgery (RGS) allows a surgeon to intraoperatively identify the lesions of interest. This technique relies on the accumulation of a radiotracer in the lesion(s) of interest. Such accumulation can occur via the local administration of the radiotracer, followed by local staining or passive drainage via the lymphatic system, or can occur via the systemic administration followed by retention or targeted accumulation of the radiotracer. The range of radiotracers applied in RGS varies from the radioactive isotope itself, to small molecules, peptides, antibodies, and colloids. The choice of the radionuclide depends on various factors, such as half-life, desired radiation type and energy, and (chemical) means to attach it to an active entity. An often overlooked factor is the radiation burden for the patient and the medical personnel. The introduction of optical imaging technologies, such as fluorescence and Cherenkov imaging, expands the utility of RGS.

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Acknowledgments

This work was financially supported by a Netherlands Organisation for Scientific Research VIDI grant (NWO; STW BGT 11272).

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Authors and Affiliations

  1. Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center (LUMC), Leiden, The Netherlands

    Anton Bunschoten, Nynke S. van den Berg, Renato A. Valdés Olmos & Fijs W. B. van Leeuwen

  2. Departments of Nuclear Medicine, Antoni van Leeuwenhoek Hospital - Netherlands Cancer Institute (AvL-NKI), Amsterdam, The Netherlands

    Renato A. Valdés Olmos

  3. Nuclear Medicine, Department of Radiology, Leiden University Medical Center (LUMC), Leiden, The Netherlands

    Jacobus A. K. Blokland

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  1. Anton Bunschoten
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  2. Nynke S. van den Berg
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  5. Fijs W. B. van Leeuwen
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  1. Universitätsklinikum Würzburg, Department of Nuclear Medicine, Würzburg, Germany

    Ken Herrmann

  2. The University of Sydney, Melanoma Institute Australia, North Sydney, New South Wales, Australia

    Omgo E. Nieweg

  3. Arthur G. James Canc Hosp Richard J. Sol, The Ohio State Univ Comp Canc CTR, Columbus, Ohio, USA

    Stephen P. Povoski

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Bunschoten, A., van den Berg, N.S., Valdés Olmos, R.A., Blokland, J.A.K., van Leeuwen, F.W.B. (2016). Tracers Applied in Radioguided Surgery. In: Herrmann, K., Nieweg, O., Povoski, S. (eds) Radioguided Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-26051-8_5

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