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Enteral and Parenteral l-Arginine Supplementation in Intestinal Ischaemia and Reperfusion Injury

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L-Arginine in Clinical Nutrition

Part of the book series: Nutrition and Health ((NH))

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Abstract

Among the internal organs, the intestine, especially the small intestine, is the most sensitive organ to ischaemia and reperfusion (I–R) damages. Intestinal ischaemia, a common and serious clinical condition resulting from numerous clinical diseases, including haemorrhagic shock, necrotising enterocolitis, sepsis, burn, vascular surgery, small bowel transplantation, cardiopulmonary bypass and abdominal aortic surgery, is a life-threatening abdominal emergency. When intestinal ischaemia occurs, rapid restoration of mesenteric blood flow is crucial; however, reperfusion may exacerbate vascular and tissue damage and result in local mucosal injury, systemic inflammation and multiple organ failure (MOF) (Vollmar and Menger, Langenbeck’s Arch Surg 396:13–29, 2011). In the late 1990s, the mortality rate of intestinal I–R was 60–80 % in the USA. In recent years, the in-hospital mortality rates of intestinal I–R remain as high as 55.1 %, mainly due to MOF, even with advanced clinical techniques (Alhan et al., Int J Surg 10:510–513, 2012).

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Author information

Authors and Affiliations

  1. Department of Nutrition, Chi-Mei Medical Center, #901, Zhonghua Rd., Yongkang Dist., Tainan, 71004, Taiwan

    Chun-Hong Lai RD, MS

  2. Department of Nutritional Science, Fu Jen Catholic University, #510 Zhongzheng Rd., Xinzhuang Dist., New Taipei, 24205, Taiwan

    Hui-Chen Lo PhD

Authors
  1. Chun-Hong Lai RD, MS
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Correspondence to Hui-Chen Lo PhD .

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Editors and Affiliations

  1. Faculty of Science & Technology Department of Biomedical Sciences, University of Westminster, London, United Kingdom

    Vinood B. Patel

  2. Department Nutrition and Dietetics Nutritional Sciences Division School of Biomedical & Health Sciences, King’s College London, London, United Kingdom

    Victor R. Preedy

  3. Nutritional Sciences Research Division Faculty of Life Science and Medicine, King’s College London, London, United Kingdom

    Rajkumar Rajendram

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Lai, CH., Lo, HC. (2017). Enteral and Parenteral l-Arginine Supplementation in Intestinal Ischaemia and Reperfusion Injury. In: Patel, V., Preedy, V., Rajendram, R. (eds) L-Arginine in Clinical Nutrition. Nutrition and Health. Humana Press, Cham. https://doi.org/10.1007/978-3-319-26009-9_28

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  • DOI: https://doi.org/10.1007/978-3-319-26009-9_28

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  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-26007-5

  • Online ISBN: 978-3-319-26009-9

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