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Molecular Basis of Colorectal Cancer and Overview of Inherited Colorectal Cancer Syndromes

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Abstract

Colorectal cancer etiology is multifactorial, with genetic and environmental factors contributing to various degrees in each individual patient. Underlying genetic and molecular pathways produce unique subsets of colorectal cancers that have distinct but somewhat overlapping phenotypes: chromosomal instability, microsatellite instability, and DNA hypermethylation. These changes are manifest in both sporadic cancers and in hereditary syndromes. Clinicians must be aware of the various underlying genetic and molecular causes of disease as it impacts clinical management, particularly in the hereditary syndromes. This chapter summarizes the main genetic causes of colorectal cancer and the clinical presentation and management of the hereditary colorectal cancer syndromes.

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Authors and Affiliations

  1. Department of Colorectal Surgery, Cleveland Clinic, 9500 Euclid Avenue, A30, Cleveland, OH, 44195, USA

    Matthew F. Kalady MD

  2. Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Y. Nancy You MD, MHSc

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Correspondence to Matthew F. Kalady MD .

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Editors and Affiliations

  1. Division of Colorectal Surgery, University Hospitals Case Medical Center Case Western Reserve University, Cleveland, OH, USA

    Scott R. Steele

  2. Cleveland Clinic, Cleveland, OH, USA

    Tracy L. Hull

  3. Tufts University School of Medicine, Lahey Hospital & Medical Center, Burlington, MA, USA

    Thomas E. Read

  4. Ambrose and Gladys Bowyer, Loyola University, Chicago, IL, USA

    Theodore J. Saclarides

  5. University of Texas Medical Branch at Galveston, Galveston, TX, USA

    Anthony J. Senagore

  6. Ochsner Medical Center, New Orleans, LA, USA

    Charles B. Whitlow

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© 2016 ASCRS (American Society of Colon and Rectal Surgeons)

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Kalady, M.F., You, Y.N. (2016). Molecular Basis of Colorectal Cancer and Overview of Inherited Colorectal Cancer Syndromes. In: Steele, S.R., Hull, T.L., Read, T.E., Saclarides, T.J., Senagore, A.J., Whitlow, C.B. (eds) The ASCRS Textbook of Colon and Rectal Surgery. Springer, Cham. https://doi.org/10.1007/978-3-319-25970-3_23

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  • DOI: https://doi.org/10.1007/978-3-319-25970-3_23

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