Abstract
A 71-year-old female presented to our clinic with a 3-month history of recurrent abdominal pain, nausea, and fatigue. She had a history of coronary artery disease, hypertension, and osteoarthritis. She denied significant alcohol use and was a nonsmoker. She also denied any therapeutic radiation exposure or family history of cancer. On clinical examination, she appeared dehydrated and lethargic but was hemodynamically stable. A right-sided firm, irregular, non-tender mass was palpable in the area of the right thyroid lobe measuring approximately 3 cm by examination.
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References
Givi B, Shah JP. Parathyroid carcinoma. Clin Oncol (R Coll Radiol). 2010;22(6):498–507.
Wilder RM. Hyperparathyroidism: tumor of the parathyroid glands associated with osteitis fibrosa. Endocrinology. 1929;13:231–44.
Wassif WS, Moniz CF, Friedman E, et al. Familial isolated hyperparathyroidism: a distinct genetic entity with an increased risk of parathyroid cancer. J Clin Endocrinol Metab. 1993;77:1485–9.
Agha A, Carpenter R, Bhattacharya S, Edmonson SJ, Carlsen E, Monson JP. Parathyroid carcinoma in multiple endocrine neoplasia type 1 (MEN1) syndrome: two case reports of an unrecognised entity. J Endocrinol Invest. 2007;30:145e149.
Sharretts JM, Simonds WF. Clinical and molecular genetics of parathyroid neoplasms. Best Pract Res Clin Endocrinol Metabol. 2010;24(3):491–502.
Robert JH, Trombetti A, Garcia A, Pache JC, Herrmann F, Spiliopoulos A, Rizzoli R. Primary hyperparathyroidism: can parathyroid carcinoma be anticipated on clinical and biochemical grounds? Report of nine cases and review of the literature. Ann Surg Oncol. 2005;12(7):526.
Wynne AG, van Heerden J, Carney JA, Fitzpatrick LA. Parathyroid carcinoma: clinical and pathologic features in 43 patients. Medicine (Baltimore). 1992;71(4):197–205.
Shane E. Clinical review 122: parathyroid carcinoma. J Clin Endocrinol Metab. 2001;86:485e493.
Johnston LB, Carroll MJ, Britton KE, Lowe DG, Shand W, Besser GM, et al. The accuracy of parathyroid gland localization in primary hyperparathyroidism using Sestamibi radionuclide imaging. J Clin Endocrinol Metab. 1996;81:346.
Chen CC, Holder LE, Scovili WA, Tehan AM, Gann DS. Comparison of parathyroid imaging with technetium-99m-pertechnetate/sestamibi subtraction, double-phase technetium-99m-sestamibi and technetium-99m-sestamibi SPECT. J Nucl Med. 1997;38(6):834–9.
Spinelli C, Bonadio AG, Berti P, Materazzi G, Miccoli P. Cutaneous spreading of parathyroid carcinoma after fine needle aspiration cytology. J Endocrinol Invest. 2000;23:255e257.
Koea JB, Shaw JH. Parathyroid cancer: biology and management. Surg Oncol. 1999;8:155e165.
Obara T, Fujimoto Y. Diagnosis and treatment of patients with parathyroid carcinoma: an update and review. World J Surg. 1991;15(6):738.
Schantz A, Castleman B. Parathyroid carcinoma. A study of 70 cases. Cancer. 1973;31:600e605.
McKeown PP, McGarity WC, Sewell CW. Carcinoma of the parathyroid gland: is it overdiagnosed? A report of three cases. Am J Surg. 1984;147:292e298.
Bondeson L, Sandelin K, Grimelius L. Histopathological variables and DNA cytometry in parathyroid carcinoma. Am J Surg Pathol. 1993;17(8):820–9.
Klein R. Hypocalcemia. In: Loriaux L, editor. Endocrine emergencies: recognition and treatment. New York: Springer; 2010. p. 149–60.
Kebebew E. Parathyroid carcinoma. Curr Treat Options Oncol. 2001;2:347e354.
Kebebew E, Arici C, Duh QY, Clark OH. Localization and reoperation results for persistent and recurrent parathyroid carcinoma. Arch Surg. 2001;136(8):878–85.
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Shariq, O.A., McKenzie, T.J. (2016). Parathyroid Carcinoma. In: Kearns, A., Wermers, R. (eds) Hyperparathyroidism. Springer, Cham. https://doi.org/10.1007/978-3-319-25880-5_10
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