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Asymptomatic Primary Hyperparathyroidism

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Hyperparathyroidism

Abstract

Primary hyperparathyroidism (PHPT) is common, with epidemiological studies suggesting it may affect up to 3 % of postmenopausal females. The most common presentation is asymptomatic hypercalcemia. Although surgery is unambiguously recommended for symptomatic PHPT patients, management options for asymptomatic patients can vary between surgery, observation, and follow-up. In cases of asymptomatic PHPT, a thorough evaluation of PHPT-related complications should be performed and patients who do not meet surgical criteria or are unable to proceed with parathyroidectomy should be monitored on an annual basis, since over time, approximately one-third of patients will demonstrate disease progression.

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References

  1. Griebeler ML, Kearns AE, Ryu E, Hathcock MA, Melton 3rd LJ, Wermers RA. Secular trends in the incidence of primary hyperparathyroidism over five decades (1965−2010). Bone. 2015;73:1–7.

    Article  PubMed  Google Scholar 

  2. Samuels MH, Veldhuis J, Cawley C, Urban RJ, Luther M, Bauer R, et al. Pulsatile secretion of parathyroid hormone in normal young subjects: assessment by deconvolution analysis. J Clin Endocrinol Metab. 1993;77(2):399–403.

    PubMed  CAS  Google Scholar 

  3. Calvo MS, Eastell R, Offord KP, Bergstralh EJ, Burritt MF. Circadian variation in ionized calcium and intact parathyroid hormone: evidence for sex differences in calcium homeostasis. J Clin Endocrinol Metab. 1991;72(1):69–76.

    Article  PubMed  CAS  Google Scholar 

  4. Schmitt CP, Schaefer F, Bruch A, Veldhuis JD, Schmidt-Gayk H, Stein G, et al. Control of pulsatile and tonic parathyroid hormone secretion by ionized calcium. J Clin Endocrinol Metab. 1996;81(12):4236–43.

    PubMed  CAS  Google Scholar 

  5. Insogna KL, Mitnick ME, Stewart AF, Burtis WJ, Mallette LE, Broadus AE. Sensitivity of the parathyroid hormone-1,25-dihydroxyvitamin D axis to variations in calcium intake in patients with primary hyperparathyroidism. N Engl J Med. 1985;313(18):1126–30.

    Article  PubMed  CAS  Google Scholar 

  6. Tohme JF, Bilezikian JP, Clemens TL, Silverberg SJ, Shane E, Lindsay R. Suppression of parathyroid hormone secretion with oral calcium in normal subjects and patients with primary hyperparathyroidism. J Clin Endocrinol Metab. 1990;70(4):951–6.

    Article  PubMed  CAS  Google Scholar 

  7. Rao DS, Honasoge M, Divine GW, Phillips ER, Lee MW, Ansari MR, et al. Effect of vitamin D nutrition on parathyroid adenoma weight: pathogenetic and clinical implications. J Clin Endocrinol Metab. 2000;85(3):1054–8.

    PubMed  CAS  Google Scholar 

  8. Grey A, Lucas J, Horne A, Gamble G, Davidson JS, Reid IR. Vitamin D repletion in patients with primary hyperparathyroidism and coexistent vitamin D insufficiency. J Clin Endocrinol Metab. 2005;90(4):2122–6.

    Article  PubMed  CAS  Google Scholar 

  9. Lundgren E, Hagstrom EG, Lundin J, Winnerback K, Roos J, Ljunghall S, et al. Primary hyperparathyroidism revisited in menopausal women with serum calcium in the upper normal range at population-based screening 8 years ago. World J Surg. 2002;26(8):931–6.

    Article  PubMed  Google Scholar 

  10. Lowe H, McMahon DJ, Rubin MR, Bilezikian JP, Silverberg SJ. Normocalcemic primary hyperparathyroidism: further characterization of a new clinical phenotype. J Clin Endocrinol Metab. 2007;92(8):3001–5.

    Article  PubMed  CAS  Google Scholar 

  11. Tuna MM, Caliskan M, Unal M, Demirci T, Dogan BA, Kucukler K, et al. Normocalcemic hyperparathyroidism is associated with complications similar to those of hypercalcemic hyperparathyroidism. J Bone Miner Metab. 2015 [ahead of print].

    Google Scholar 

  12. Chen G, Xue Y, Zhang Q, Xue T, Yao J, Huang H, et al. Is normocalcemic primary hyperparathyroidism harmful or harmless? J Clin Endocrinol Metab. 2015;100(6):2420–4.

    Article  PubMed  CAS  Google Scholar 

  13. Bilezikian JP, Brandi ML, Eastell R, Silverberg SJ, Udelsman R, Marcocci C, et al. Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop. J Clin Endocrinol Metab. 2014;99(10):3561–9.

    Article  PubMed  CAS  Google Scholar 

  14. Silverberg SJ, Shane E, Dempster DW, Bilezikian JP. The effects of vitamin D insufficiency in patients with primary hyperparathyroidism. Am J Med. 1999;107(6):561–7.

    Article  PubMed  CAS  Google Scholar 

  15. Locker FG, Silverberg SJ, Bilezikian JP. Optimal dietary calcium intake in primary hyperparathyroidism. J Clin Endocrinol Metab. 1997;102(6):543–50.

    CAS  Google Scholar 

  16. Marcocci C, Bollerslev J, Khan AA, Shoback DM. Medical management of primary hyperparathyroidism: proceedings of the fourth International Workshop on the Management of Asymptomatic Primary Hyperparathyroidism. J Clin Endocrinol Metab. 2014;99(10):3607–18.

    Article  PubMed  CAS  Google Scholar 

  17. Rubin MR, Bilezikian JP, McMahon DJ, Jacobs T, Shane E, Siris E, et al. The natural history of primary hyperparathyroidism with or without parathyroid surgery after 15 years. J Clin Endocrinol Metab. 2008;93(9):3462–70.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  18. Silverberg SJ, Shane E, Jacobs TP, Siris E, Bilezikian JP. A 10-year prospective study of primary hyperparathyroidism with or without parathyroid surgery. N Engl J Med. 1999;341(17):1249–55.

    Article  PubMed  CAS  Google Scholar 

  19. Mollerup CL, Vestergaard P, Frokjaer VG, Mosekilde L, Christiansen P, Blichert-Toft M. Risk of renal stone events in primary hyperparathyroidism before and after parathyroid surgery: controlled retrospective follow up study. BMJ. 2002;325(7368):807.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Zanocco K, Butt Z, Kaltman D, Elaraj D, Cella D, Holl JL, et al. Improvement in patient-reported physical and mental health after parathyroidectomy for primary hyperparathyroidism. Surgery. 2015;158:837–45.

    Article  PubMed  Google Scholar 

  21. Espiritu RP, Kearns AE, Vickers KS, Grant C, Ryu E, Wermers RA. Depression in primary hyperparathyroidism: prevalence and benefit of surgery. J Clin Endocrinol Metab. 2011;96(11):E1737–45.

    Article  PubMed  CAS  Google Scholar 

  22. Weber T, Eberle J, Messelhauser U, Schiffmann L, Nies C, Schabram J, et al. Parathyroidectomy, elevated depression scores, and suicidal ideation in patients with primary hyperparathyroidism: results of a prospective multicenter study. JAMA Surg. 2013;148(2):109–15.

    Article  PubMed  Google Scholar 

  23. Stavrakis AI, Ituarte PH, Ko CY, Yeh MW. Surgeon volume as a predictor of outcomes in inpatient and outpatient endocrine surgery. Surgery. 2007;142(6):887–99; discussion -99.

    Article  PubMed  Google Scholar 

  24. Mitchell J, Milas M, Barbosa G, Sutton J, Berber E, Siperstein A. Avoidable reoperations for thyroid and parathyroid surgery: effect of hospital volume. Surgery. 2008;144(6):899–906; discussion -7.

    Article  PubMed  Google Scholar 

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Correspondence to Robert A. Wermers MD .

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© 2016 Mayo Foundation for Medical Education and Research

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Delivanis, D.A., Wermers, R.A. (2016). Asymptomatic Primary Hyperparathyroidism. In: Kearns, A., Wermers, R. (eds) Hyperparathyroidism. Springer, Cham. https://doi.org/10.1007/978-3-319-25880-5_1

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  • DOI: https://doi.org/10.1007/978-3-319-25880-5_1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-25878-2

  • Online ISBN: 978-3-319-25880-5

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