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Antimicrobial Agents for Ocular Use: Bacterial, Fungal, Viral, and Protozoal Infections

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Pharmacology of Ocular Therapeutics

Abstract

Ocular microbial infections are one of the leading causes of avoidable visual impairment in the world with higher prevalence in developing countries. The incidence and organism responsible for ocular infections are attributed to indiscriminate use of antibiotics, corticosteroids, poor sanitary conditions, rising trend of the use of contact lens etc. A wide variety of microorganisms; bacterial, fungal, viral and protozoal in origin are reported to be involved in ocular infections. These ocular infections include conjunctivitis, blepharitis, endophthalmitis and corneal ulcers which are vision threatening if not treated in time. This chapter dwells with the type of antibiotics/antimicrobial agents used for bacterial, fungal, viral and protozoal ocular infections and provides the insight for the judicious use of antibiotics/antimicrobial agents in treating these infections.

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References

  • A controlled trial of oral acyclovir for iridocyclitis caused by herpes simplex virus. The Herpetic Eye Disease Study Group. Arch Ophthalmol. 1996;114(9):1065–72.

    Google Scholar 

  • A controlled trial of oral acyclovir for the prevention of stromal keratitis or iritis in patients with herpes simplex virus epithelial keratitis. The Epithelial Keratitis Trial. The Herpetic Eye Disease Study Group. Arch Ophthalmol. 1997;115(6):703–12.

    Google Scholar 

  • Acyclovir for the prevention of recurrent herpes simplex virus eye disease. Herpetic Eye Disease Study Group. N Engl J Med. 1998;339(5):300–6.

    Google Scholar 

  • Altun A, Kurna SA, Sengor T, Altun G, Olcaysu OO, Aki SF, Simsek MH. Effectiveness of posaconazole in recalcitrant fungal keratitis resistant to conventional antifungal drugs. Case Rep Ophthalmol Med. 2014;2014:701653.

    PubMed Central  PubMed  CAS  Google Scholar 

  • Barron BA, Gee L, Hauck WW, Kurinij N, et al. Herpetic Eye disease study. A controlled trial of oral acyclovir for herpes simplex stromal keratitis. Ophthalmology. 1994;101(12):1871–82.

    Article  PubMed  CAS  Google Scholar 

  • Biron KK, Elion GB. In vitro susceptibility of varicella-zoster virus to acyclovir. Antimicrob Agents Chemother. 1980;18(3):443–7.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Boston Interhospital Viral Study Group. Failure of high dose 5-iodo-2’-deoxyuridine in the therapy of herpes simplex virus encephalitis. Evidence of unacceptable toxicity. N Engl J Med. 1975;292(12):599–603.

    Article  Google Scholar 

  • Coster DJ, McKinnon JR, McGill JI, Jones BR, Fraunfelder FT. Clinical evaluation of adenine arabinoside and trifluorothymidine in the treatment of corneal ulcers caused by herpes simplex virus. J Infect Dis. 1976;133(Suppl):A173–7.

    Article  PubMed  Google Scholar 

  • Davies ME, Bondi JV, Grabowski L, Schofield TL, Field AK. 2’-nor-2’deoxyguanosine is an effective therapeutic agent for treatment of experimental herpes keratitis. Antiviral Res. 1987;7(2):119–25.

    Article  PubMed  CAS  Google Scholar 

  • Dupuis A, Tournier N, Le Moal G, Venisse N. Preparation and stability of voriconazole eye drop solution. Antimicrob Agents Chemother. 2009;53(2):798–9.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Elion GB. Mechanism of action and selectivity of acyclovir. Am J Med. 1982;73(1A):7–13.

    Article  PubMed  CAS  Google Scholar 

  • Foster CS, Stefanyszyn M. Intraocular penetration of miconazole in rabbits. Arch Ophthalmol. 1979;97(9):1703–6.

    Article  PubMed  CAS  Google Scholar 

  • Gao H, Pennesi M, Shah K, Qiao X, Hariprasad SM, Mieler WF, et al. Safety of intravitreal voriconazole: electroretinographic and histopathologic studies. Trans Am Ophthalmol Soc. 2003;101:183–9.

    PubMed  Google Scholar 

  • Goldblum D, Frueh BE, Sarra GM, Katsoulis K, Zimmerli S. Topical caspofungin for treatment of keratitis caused by Candida albicans in a rabbit model. Antimicrob Agents Chemother. 2005;49(4):1359–63.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Hurtado-Sarrió M, Duch-Samper A, Cisneros-Lanuza A, Díaz-Llopis M, Peman-Garcíia J, Vazquez-Polo A. Successful topical application of caspofungin in the treatment of fungal keratitis refractory to voriconazole. Arch Ophthalmol. 2010;128(7):941–2.

    Article  PubMed  Google Scholar 

  • Kalavathy CM, Parmar P, Kaliamurthy J, Philip VR, Ramalingam MD, Jesudasan CA, Thomas PA. Comparison of topical itraconazole 1% with topical natamycin 5% for the treatment of filamentous fungal keratitis. Cornea. 2005;24(4):449–52.

    Article  PubMed  CAS  Google Scholar 

  • Kaufman H, Martola E, Dohlman C. Use of 5-iodo-2’-deoxyuridine (IDU) in treatment of herpes simplex keratitis. Arch Ophthalmol. 1962a;68:235–9.

    Article  PubMed  CAS  Google Scholar 

  • Kaufman HE, Heidelberger C. Therapeutic antiviral action of 5-trifluoromethyl-2’-deoxyuridine in herpes simplex keratitis. Science. 1964;145(3632):585–6.

    Article  PubMed  CAS  Google Scholar 

  • Kaufman HE, Nesburn AB, Maloney ED. IDU therapy of herpes simplex. Arch Ophthalmol. 1962b;67:583–91.

    Article  PubMed  CAS  Google Scholar 

  • Kaur IP, Rana C, Singh H. Development of effective ocular preparations of antifungal agents. J Ocul Pharmacol Ther. 2008;24(5):481–93. Review.

    Article  PubMed  CAS  Google Scholar 

  • Khoo SH, Bond J, Denning DW. Administering amphotericin B—a practical approach. J Antimicrob Chemother. 1994;33(2):203–13.

    Article  PubMed  CAS  Google Scholar 

  • Klotz SA, Zahid M, Bartholomew WR, Revera PM, Butrus S. Candida albicans keratitis treated successfully with itraconazole. Cornea. 1996;15(1):102–4.

    Article  PubMed  CAS  Google Scholar 

  • Kobayashi D, Kondo K, Uehara N, Otokozawa S, Tsuji N, Yagihashi A, Watanabe N. Endogenous reactive oxygen species is an important mediator of miconazole antifungal effect. Antimicrob Agents Chemother. 2002;46(10):3113–7.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Lalitha P, Shapiro BL, Srinivasan M, Prajna NV, Acharya NR, Fothergill AW, et al. Antimicrobial susceptibility of Fusarium, Aspergillus, and other filamentous fungi isolated from keratitis. Arch Ophthalmol. 2007;125(6):789–93.

    Article  PubMed  CAS  Google Scholar 

  • Larder BA, Darby G. Susceptibility to other antiherpes drugs of pathogenic variants of herpes simplex virus selected for resistance to acyclovir. Antimicrob Agents Chemother. 1986;29(5):894–8.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Lee W, Benitez A, Goodman L, Baker BR. Potential Anticancer Agents. XL. Synthesis of the β-Anomer of 9-(D-Arabinofuranosyl)adenine. J Am Chem Soc. 1960;82:2648–9.

    Article  CAS  Google Scholar 

  • Li L, Wang Z, Li R, Luo S, Sun X. In vitro evaluation of combination antifungal activity against Fusarium species isolated from ocular tissues of keratomycosis patients. Am J Ophthalmol. 2008;146(5):724–8.

    Article  PubMed  CAS  Google Scholar 

  • Lin HC, Chu PH, Kuo YH, Shen SC. Clinical experience in managing Fusarium solani keratitis. Int J Clin Pract. 2005;59(5):549–54.

    Article  PubMed  Google Scholar 

  • Martinez R. Atualização no uso de agentes antifúngicos. J Bras Pneumol. 2006;32(5):449–60.

    Article  PubMed  Google Scholar 

  • Morris MI, Villmann M. Echinocandins in the management of invasive fungal infections, part 1. Am J Health Syst Pharm. 2006;63(18):1693–703. Review.

    Article  PubMed  CAS  Google Scholar 

  • Nicholson KG. Properties of antiviral agents. 1. Lancet. 1984;2(8401):503–6.

    Article  PubMed  CAS  Google Scholar 

  • O’Day DM, Foulds G, Williams TE, Robinson RD, Allen RH, Head WS. Ocular uptake of fluconazole following oral administration. Arch Ophthalmol. 1990;108(7):1006–8.

    Article  PubMed  Google Scholar 

  • O’Day DM, Ray WA, Head WS, Robinson RD. Influence of the corneal epithelium on the efficacy of topical antifungal agents. Invest Ophthalmol Vis Sci. 1984;25(7):855–9.

    PubMed  Google Scholar 

  • O’Day DM. Selection of appropriate antifungal therapy. Cornea. 1987;6(4):238–45. Review.

    Article  PubMed  Google Scholar 

  • O’Day DM, Head WS, Robinson RD, Stern WH, Freeman JM. Intraocular penetration of systemically administered antifungal agents. Curr Eye Res. 1985;4(2):131–4.

    Article  PubMed  Google Scholar 

  • Panda A, Sharma N, Angra SK. Topical fluconazole therapy of Candida keratitis. Cornea. 1996;15(4):373–5.

    Article  PubMed  CAS  Google Scholar 

  • Prajna NV, Krishnan T, Mascarenhas J, Rajaraman R, Prajna L, Srinivasan M, Raghavan A, Oldenburg CE, Ray KJ, Zegans ME, McLeod SD, Porco TC, Acharya NR, Lietman TM, Mycotic Ulcer Treatment Trial Group. The mycotic ulcer treatment trial: a randomized trial comparing natamycin vs voriconazole. JAMA Ophthalmol. 2013;131(4):422–9.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Prajna NV, Mascarenhas J, Krishnan T, Reddy PR, Prajna L, Srinivasan M, et al. Comparison of natamycin and voriconazole for the treatment of fungal keratitis. Arch Ophthalmol. 2010;128(6):672–8.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Prakash G, Sharma N, Goel M, Titiyal JS, Vajpayee RB. Evaluation of intrastromal injection of voriconazole as a therapeutic adjunctive for the management of deep recalcitrant fungal keratitis. Am J Ophthalmol. 2008;146(1):56–9.

    Article  PubMed  Google Scholar 

  • Prusoff WH, Zucker M, Mancini WR, Otto MJ, Lin TS, Lee JJ. Basic biochemical and pharmacological aspects of antiviral agents. Antiviral Res. 1985;Suppl 1:1–10.

    Google Scholar 

  • Rajaraman R, Bhat P, Vaidee V, Maskibail S, Raghavan A, Sivasubramaniam S, Rajasekaran J, Thomas PA, Kalavathy CM, Joseph PC, Abraham DJ. Itraconazole therapy for fungal keratitis. Indian J Ophthalmol. 1987;35(5–6):157–60.

    Google Scholar 

  • Sacks SL, Scullard GH, Pollard RB, Gregory PB, Robinson WS, Merigan TC. Antiviral treatment of chronic hepatitis B virus infection: pharmacokinetics and side effects of interferon and adenine arabinoside alone and in combination. Antimicrob Agents Chemother. 1982;21(1):93–100.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Sharma N, Chacko J, Velpandian T, Titiyal JS, Sinha R, Satpathy G, Tandon R, Vajpayee RB. Comparative evaluation of topical versus intrastromal voriconazole as an adjunct to natamycin in recalcitrant fungal keratitis. Ophthalmology. 2013a;120(4):677–81.

    Article  PubMed  Google Scholar 

  • Sharma S, Das S, Virdi A, Fernandes M, Sahu SK, Kumar Koday N, Ali MH, Garg P, Motukupally SR. Re-appraisal of topical 1% voriconazole and 5% natamycin in the treatment of fungal keratitis in a randomised trial. Br J Ophthalmol. 2015;99(9):1190–5.

    Google Scholar 

  • Torres MA, Mohamed J, Cavazos-Adame H, Martinez LA. Topical ketoconazole for fungal keratitis. Am J Ophthalmol. 1985;100(2):293–8.

    Article  PubMed  CAS  Google Scholar 

  • Travers JP, Patterson A. A controlled trial of adenine arabinoside and trifluorothymidine in herpetic keratitis. J Int Med Res. 1978;6(2):102–4.

    Article  PubMed  CAS  Google Scholar 

  • Urbak SF, Degn T. Fluconazole in the management of fungal ocular infections. Ophthalmologica. 1994;208(3):147–56.

    Article  PubMed  CAS  Google Scholar 

  • Van Bijsterveld OP, Post H. Trifluorothymidine versus adenine arabinoside in the treatment of herpes simplex keratitis. Br J Ophthalmol. 1980;64(1):33–6.

    Article  PubMed Central  PubMed  Google Scholar 

  • Vermes A, Guchelaar HJ, Dankert J. Flucytosine: a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions. J Antimicrob Chemother. 2000;46(2):171–9.

    Article  PubMed  CAS  Google Scholar 

  • Wagstaff AJ, Faulds D, Goa KL. Aciclovir. A reappraisal of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1994;47(1):153–205.

    Article  PubMed  CAS  Google Scholar 

  • Wilhelmus KR. The treatment of herpes simplex virus epithelial keratitis. Trans Am Ophthalmol Soc. 2000;98:505–32.

    PubMed Central  PubMed  CAS  Google Scholar 

  • Wilson 2nd FM. Adverse external ocular effects of topical ophthalmic medications. Surv Ophthalmol. 1979;24(2):57–88.

    Article  PubMed  Google Scholar 

  • Yoon KC, Jeong IY, Im SK, Chae HJ, Yang SY. Therapeutic effect of intracameral amphotericin B injection in the treatment of fungal keratitis. Cornea. 2007;26(7):814–8.

    Article  PubMed  Google Scholar 

  • Agarwal AK, Ram J, Singh R. Sparfloxacin-associated corneal epithelial toxicity. BMJ Case Rep. 2014;19:2014.

    Google Scholar 

  • Ahmed S, Kuruvilla O, Yee DC, et al. Intraocular penetration of systemic antibiotics in eyes with penetrating ocular injury. J Ocul Pharmacol Ther. 2014;30(10):823–30.

    Article  PubMed  CAS  Google Scholar 

  • Akyol-Salman I, Azizi S, Mumcu UY, et al. Comparison of the efficacy of topical N-acetyl-cysteine and a topical steroid-antibiotic combination therapy in the treatment of meibomian gland dysfunction. J Ocul Pharmacol Ther. 2012;28(1):49–52.

    Article  PubMed  CAS  Google Scholar 

  • Andreoli CM, Wiley HE, Durand ML, et al. Primary meningococcal conjunctivitis in an adult. Cornea. 2004;23(7):738–9.

    Article  PubMed  Google Scholar 

  • Baneke A. Review: targeting trachoma: strategies to reduce the leading infectious cause of blindness. Travel Med Infect Dis. 2012;10(2):92–6.

    Article  PubMed  Google Scholar 

  • Benson CE, Soliman MK, Knezevic A, et al. Bilateral papillitis and unilateral focal chorioretinitis as the presenting features of syphilis. J Ophthalmic Inflamm Infect. 2015;5:16.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Blanco AR, SudanoRoccaro A, Spoto CG, et al. Susceptibility of methicillin-resistant Staphylococci clinical isolates to netilmicin and other antibiotics commonly used in ophthalmic therapy. Curr Eye Res. 2013;38(8):811–6.

    Article  PubMed  CAS  Google Scholar 

  • Cagini C, Piccinelli F, Lupidi M, et al. Ocular penetration of topical antibiotics: study on the penetration of chloramphenicol, tobramycin and netilmicin into the anterior chamber after topical administration. Clin Experiment Ophthalmol. 2013;41(7):644–7.

    PubMed  Google Scholar 

  • Chang VS, Dhaliwal DK, Raju L, Kowalski RP. Antibiotic resistance in the treatment of staphylococcus aureus keratitis: a 20-year review. Cornea. 2015;34(6):698–703.

    Article  PubMed  Google Scholar 

  • Chen C, Chen Y, Wu P, et al. Update on new medicinal applications of gentamicin: evidence-based review. J Formos Med Assoc. 2014;113(2):72–82.

    Article  PubMed  CAS  Google Scholar 

  • Chew FL, Soong TK, Shin HC, et al. Topical piperacillin/tazobactam for recalcitrant pseudomonas aeruginosa keratitis. J Ocul Pharmacol Ther. 2010;26(2):219–22.

    Article  PubMed  CAS  Google Scholar 

  • Cosar CB, Cohen EJ, Rapuano CJ, et al. Clear corneal wound infection after phacoemulsification. Arch Ophthalmol. 2001;119(12):1755–9.

    Article  PubMed  CAS  Google Scholar 

  • Darling EK, McDonald H. A meta-analysis of the efficacy of ocular prophylactic agents used for the prevention of gonococcal and chlamydial ophthalmianeonatorum. J Midwifery Womens Health. 2010;55(4):319–27.

    Article  PubMed  Google Scholar 

  • Donnenfeld ED, O’Brien TP, Solomon R, et al. Infectious keratitis after photorefractive keratectomy. Ophthalmology. 2003;110(4):743–7.

    Article  PubMed  Google Scholar 

  • Erdem E, Abdurrahmanoglu S, Kibar F, et al. Posttraumatic keratitis caused by Elizabeth kingiameningosepticum. Eye Contact Lens. 2013;39(5):361–3.

    Article  PubMed  Google Scholar 

  • Foulks GN, Borchman D, Yappert M, et al. Topical azithromycin and oral doxycycline therapy of meibomian gland dysfunction: a comparative clinical and spectroscopic pilot study. Cornea. 2013;32(1):44–53.

    Article  PubMed Central  PubMed  Google Scholar 

  • Freitas D, Alvarenga L, Sampaio J, et al. An outbreak of Mycobacterium chelonae infection after LASIK. Ophthalmology. 2003;110(2):276–85.

    Article  PubMed  Google Scholar 

  • Fukuda M, Ohashi H, Matsumoto C, et al. Methicillin-resistant Staphylococcus aureus and methicillin-resistant coagulase-negative Staphylococcus ocular surface infection efficacy of chloramphenicol eye drops. Cornea. 2002;21(7 Suppl):S86–9.

    Article  PubMed  Google Scholar 

  • Garg P, Mathur U, Sony P, et al. Clinical and antibacterial efficacy and safety of besifloxacin ophthalmic suspension compared with moxifloxacin ophthalmic solution. Asia Pac J Ophthalmol (Phila). 2015;4(3):140–5.

    Article  CAS  Google Scholar 

  • Garnock-Jones KP. Azithromycin 1.5% ophthalmic solution: in purulent bacterial or trachomatous conjunctivitis. Drugs. 2012;72(3):361–73.

    Article  PubMed  CAS  Google Scholar 

  • Gentile RC, Shukla S, Shah M, et al. Microbiological spectrum and antibiotic sensitivity in endophthalmitis: a 25-year review. Ophthalmology. 2014;121(8):1634–42.

    Article  PubMed  Google Scholar 

  • Graffi S, Peretz A, Naftali M. Endogenous endophthalmitis with an unusual infective agent: Actinomyces neuii. Eur J Ophthalmol. 2012;22(5):834–5.

    PubMed  Google Scholar 

  • Heller W, Cruz M, Bhagat YR, et al. Gatifloxacin 0.5% administered twice daily for the treatment of acute bacterial conjunctivitis in patients one year of age or older. J Ocul Pharmacol Ther. 2014;30(10):815–22.

    Article  PubMed  CAS  Google Scholar 

  • Hsiao CH, Chuang CC, Tan HY, Ma DH, Lin KK, Chang CJ, Huang YC. Methicillin-resistant Staphylococcus aureus ocular infection: a 10-year hospital-based study. Ophthalmology. 2012;119(3):522–7. doi: 10.1016/j.ophtha.2011.08.038. Epub 2011 Dec 15.

    Google Scholar 

  • Jain R, Murthy SI, Motukupally SR, et al. Use of topical colistin in multiple drug-resistant Pseudomonas aeruginosa bacterial keratitis. Cornea. 2014;33(9):923–7.

    Article  PubMed  Google Scholar 

  • Katibeh M, Ziaei H, Mirzaei M, et al. Perioperative prophylaxis for endophthalmitis after cataract surgery in iran. J Ophthalmic Vis Res. 2015;10(1):33–6.

    Article  PubMed Central  PubMed  Google Scholar 

  • Keenan JD, Moncada J, Gebre T, et al. Chlamydial infection during trachoma monitoring: are the most difficult-to-reach children more likely to be infected? Trop Med Int Health. 2012;17(3):392–6.

    PubMed Central  PubMed  Google Scholar 

  • Kessel L, Flesner P, Andresen J, et al. Antibiotic prevention of postcataract endophthalmitis: a systematic review and meta-analysis. Acta Ophthalmol. 2015;93(4):303–17.

    Article  PubMed  Google Scholar 

  • Koh S, Maeda N, Soma T, Hori Y, Tsujikawa M, Watanabe H, Nishida K. Development of methicillin-resistant staphylococcus aureus keratitis in a dry eye patient with a therapeutic contact lens. Eye Contact Lens. 2012;38(3):200–2.

    Article  PubMed  Google Scholar 

  • Leeming JP. Treatment of ocular infections with topical antibacterials. Clin Pharmacokinet. 1999;37(5):351–60.

    Article  PubMed  CAS  Google Scholar 

  • Li B, Miño de Kaspar H, Haritoglou C, et al. Comparison of 1-day versus 1-hour application of topical neomycin/polymyxin-B before cataract surgery. J Cataract Refract Surg. 2015;41(4):724–31.

    Article  PubMed  Google Scholar 

  • Linertová R, Abreu-González R, García-Pérez L, et al. Intracameral cefuroxime and moxifloxacin used as endophthalmitis prophylaxis after cataract surgery: systematic review of effectiveness and cost-effectiveness. Clin Ophthalmol. 2014;8:1515–22.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Khalil MA, Sonbol FI. Investigation of biofilm formation on contact eye lenses caused by methicillin resistant Staphylococcus aureus. Niger J Clin Pract. 2014;17(6):776–84.

    Article  PubMed  CAS  Google Scholar 

  • Mason BW, Howard AJ, Magee JT. Fusidic acid resistance in community isolates of methicillin-susceptible Staphylococcus aureus and fusidic acid prescribing. J Antimicrob Chemother. 2003;51(4):1033–6.

    Article  PubMed  CAS  Google Scholar 

  • McDonald EM, Ram FS, Patel DV, et al. Topical antibiotics for the management of bacterial keratitis: an evidence-based review of high quality randomised controlled trials. Br J Ophthalmol. 2014;98(11):1470–7.

    Article  PubMed  Google Scholar 

  • Mehta S, Armstrong BK, Kim SJ, et al. Long-term potency, sterility, and stability of vancomycin, ceftazidime, and moxifloxacin for treatment of bacterial endophthalmitis. Retina. 2011;31(7):1316–22.

    Article  PubMed  CAS  Google Scholar 

  • Munir WM, Rosenfeld SI, Udell I, et al. Clinical response of contact lens-associated fungal keratitis to topical fluoroquinolone therapy. Cornea. 2007;26(5):621–4.

    PubMed  Google Scholar 

  • Newman PE, Hider P, Waring 3rd GO, Hill EO, Wilson LA, Harbin TS. Corneal ulcer due to Achromobacter xylosoxidans. Br J Ophthalmol. 1984;68(7):472–4.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Nguyen AT, Hong AR, Baqai J, Lubniewski AJ, Huang AJ. Use of topical besifloxacin in the treatment of Mycobacterium chelonae Ocular Surface Infections. Cornea. 2015;34(8):967–71.

    Article  PubMed  Google Scholar 

  • Mamalis N. Ocular methicillin-resistant Staphylococcus aureus. J Cataract Refract Surg. 2014;40(11):1757–8. doi: 10.1016/j.jcrs.2014.09.016. Epub 2014 Oct 23.

    Google Scholar 

  • Ortega-Usobiaga J, Llovet-Osuna F, Djodeyre MR, et al. Incidence of corneal infections after laser in situ keratomileusis and surface ablation when moxifloxacin and tobramycin are used as postoperative treatment. J Cataract Refract Surg. 2015;18.

    Google Scholar 

  • Papa V, Aragona P, Scuderi AC, et al. Treatment of acute bacterial conjunctivitis with topical netilmicin. Cornea. 2002;21(1):43–7.

    Article  PubMed  Google Scholar 

  • Park YM, Kwon HJ, Lee JS. Microbiological study of therapeutic soft contact lenses used in the treatment of recurrent corneal erosion syndrome. Eye Contact Lens. 2015;41(2):84–6.

    Article  PubMed  Google Scholar 

  • Penha FM, Rodrigues EB, Maia M, et al. Retinal and ocular toxicity in ocular application of drugs and chemicals – part II: retinal toxicity of current and new drugs. Ophthalmic Res. 2010;44(4):205–24.

    Article  PubMed  CAS  Google Scholar 

  • Rajapakse S, Chrishan SM, Samaranayake N, et al. Antibiotics for human toxoplasmosis: a systematic review of randomized trials. Pathog Glob Health. 2013;107(4):162–9.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Rautaraya B, Sharma S, Ali MH, et al. A 3½-year study of bacterial keratitis from Odisha, India. Asia Pac J Ophthalmol (Phila). 2014;3(3):146–50.

    Article  CAS  Google Scholar 

  • Ritterband DC, Shah M, Seedor J. Antibiotic prophylaxis in clear corneal cataract surgery. Arch Ophthalmol. 2003;121(2):296. author reply 296.

    Article  PubMed  Google Scholar 

  • Robert PY, Adenis JP. Comparative review of topical ophthalmic antibacterial preparations. Drugs. 2001;61(2):175–85.

    Article  PubMed  CAS  Google Scholar 

  • Ryan ET, Durand M. Ocular disease. In: Tropical infectious diseases: principles, pathogens and practice. Saunders Elsevier 2011. p. 991–1016.

    Google Scholar 

  • Sharma R, Jhanji V, Satpathy G, et al. Coinfection with Acanthamoeba and Pseudomonas in contact lens-associated keratitis. Optom Vis Sci. 2013b;90(2):e53–5.

    Article  PubMed  Google Scholar 

  • Sharma T, Kamath MM, Kamath MG, et al. Aqueous penetration of orally and topically administered moxifloxacin. Br J Ophthalmol. 2015;30.

    Google Scholar 

  • Smith A, Pennefather PM, Kaye SB, Hart CA. Fluoroquinolones: place in ocular therapy. Drugs. 2001;61(6):747–61.

    Article  PubMed  CAS  Google Scholar 

  • Snyder RW, Glasser DB. Antibiotic therapy for ocular infection. West J Med. 1994;161:579–84.

    PubMed Central  PubMed  CAS  Google Scholar 

  • Sobolewska B, Doycheva D, Deuter C, et al. Treatment of ocular rosacea with once-daily low-dose doxycycline. Cornea. 2014;33(3):257–60.

    PubMed  Google Scholar 

  • Sridhar J, Kuriyan AE, Flynn Jr HW, et al. Endophthalmitis caused by Pseudomonas aeruginosa : clinical features, antibiotic susceptibilities, and treatment outcomes. Retina. 2015;35(6):1101–6.

    PubMed  Google Scholar 

  • Suemori S, Sawada A, Komori S, et al. Case of endogenous endophthalmitis caused by Streptococcus equisimilis. Clin Ophthalmol. 2010;4:917–8.

    PubMed Central  PubMed  Google Scholar 

  • Tinley C, Van Zyl L, Grötte R. Poststreptococcal syndrome uveitis in South African children. Br J Ophthalmol. 2012;96(1):87–9.

    Article  PubMed  Google Scholar 

  • Trichet E, Cohen-Bacrie S, Conrath J, et al. Nocardia transvalensis keratitis: an emerging pathology among travelers returning from Asia. BMC Infect Dis. 2011;11:296.

    Article  PubMed Central  PubMed  Google Scholar 

  • Vazirani J, Basu S. Role of topical, subconjunctival, intracameral, and irrigative antibiotics in cataract surgery. Curr Opin Ophthalmol. 2013;24(1):60–5.

    Article  PubMed  Google Scholar 

  • Veldman P, Colby K. Current evidence for topical azithromycin 1% ophthalmic solution in the treatment of blepharitis and blepharitis-associated ocular dryness. Int Ophthalmol Clin. 2011;51(4):43–52.

    Article  PubMed  Google Scholar 

  • Kos VN, Desjardins CA, Griggs A, Cerqueira G, Van Tonder A, et al. Comparative genomics of vancomycin-resistant staphylococcus aureus strains and their positions within the Clade Most Commonly Associated with Methicillin-Resistant S. aureus Hospital-Acquired Infection in the United States. mBio. 2012;3(3):e00112–12.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Wang L, Tsang H, Coroneo M. Treatment of recurrent corneal erosion syndrome using the combination of oral doxycycline and topical corticosteroid. Clin Experiment Ophthalmol. 2008;36(1):8–12.

    Article  PubMed  Google Scholar 

  • Williams L, Malhotra Y, Murante B, et al. A single-blinded randomized clinical trial comparing polymyxin B-trimethoprim and moxifloxacin for treatment of acute conjunctivitis in children. J Pediatr. 2013;162(4):857–61.

    Article  PubMed  CAS  Google Scholar 

  • Abrishami M, Soheilian M, Farahi A, Dowlati Y. Successful treatment of ocular leishmaniasis. Eur J Dermatol. 2002;12(1):88–9.

    PubMed  CAS  Google Scholar 

  • Andersen SL, Oloo AJ, Gordon DM, Ragama OB, Aleman GM, Berman JD, Tang DB, Dunne MW, Shanks GD. Successful double-blinded, randomized, placebo-controlled field trial of azithromycin and doxycycline as prophylaxis for malaria in western Kenya. Clin Infect Dis. 1998;26(1):146–50.

    Article  PubMed  CAS  Google Scholar 

  • Ang M, Mehta JS, Mantoo S, Tan D. Deep anterior lamellar keratoplasty to treat microsporidial stromal keratitis. Cornea. 2009;28(7):832–5.

    Article  PubMed  Google Scholar 

  • Antoniazzi E, Guagliano R, Meroni V, Pezzotta S, Bianchi PE. Ocular impairment of toxoplasmosis. Parassitologia. 2008;50(1–2):35–6.

    PubMed  CAS  Google Scholar 

  • Asproudis I, Koumpoulis I, Kalogeropoulos C, Sotiropoulos G, Papassava M, Aspiotis M. Case report of a neonate with ocular toxoplasmosis due to congenital infection: estimation of the percentage of ocular toxoplasmosis in Greece caused by congenital or acquired infection. Clin Ophthalmol. 2013;7:2249–52.

    Article  PubMed Central  PubMed  Google Scholar 

  • Baharivand N, Mahdavifard A, Fouladi RF. Intravitreal clindamycin plus dexamethasone versus classic oral therapy in toxoplasmic retinochoroiditis: a prospective randomized clinical trial. Int Ophthalmol. 2013;33(1):39–46.

    Article  PubMed  Google Scholar 

  • Balaskas K, Vaudaux J, Boillat-Blanco N, Guex-Crosier Y. Azithromycin versus Sulfadiazine and Pyrimethamine for non-vision-threatening toxoplasmic retinochoroiditis: a pilot study. Med Sci Monit. 2012;18(5):CR296–302.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Bang S, Edell E, Eghrari AO, Gottsch JD. Treatment with voriconazole in 3 eyes with resistant Acanthamoeba keratitis. Am J Ophthalmol. 2010;149(1):66–9.

    Article  PubMed  CAS  Google Scholar 

  • Barrett MP, Croft SL. Management of trypanosomiasis and leishmaniasis. Br Med Bull. 2012;104:175–96.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Bentley R. Different roads to discovery; Prontosil (hence sulfa drugs) and penicillin (hence beta-lactams). J Ind Microbiol Biotechnol. 2009;36(6):775–86.

    Article  PubMed  CAS  Google Scholar 

  • Bonfioli AA, Orefice F. Toxoplasmosis. Semin Ophthalmol. 2005;20(3):129–41.

    Article  PubMed  Google Scholar 

  • Burri C, Brun R. Eflornithine for the treatment of human African trypanosomiasis. Parasitol Res. 2003;90(Supp 1):S49–52.

    PubMed  Google Scholar 

  • Butler NJ, Furtado JM, Winthrop KL, Smith JR. Ocular toxoplasmosis II: clinical features, pathology and management. Clin Experiment Ophthalmol. 2013;41(1):95–108.

    Article  PubMed Central  PubMed  Google Scholar 

  • Cabello-Vílchez AM, Martín-Navarro CM, López-Arencibia A, Reyes-Batlle M, Sifaoui I, Valladares B, Piñero JE, Lorenzo-Morales J. Voriconazole as a first-line treatment against potentially pathogenic Acanthamoeba strains from Peru. Parasitol Res. 2014;113:755–9.

    Article  PubMed  Google Scholar 

  • Campos FA, Andrade GM, Lanna Ade P, Lage BF, Assumpção MV, Pinto JA. Incidence of congenital toxoplasmosis among infants born to HIV-coinfected mothers: case series and literature review. Braz J Infect Dis. 2014;18(6):609–17.

    Article  PubMed  Google Scholar 

  • Cassaday JV, Bahler JW, Hinken MV. Spiramycin for toxoplasmosis. Am J Ophthalmol. 1964;57:227–35.

    Article  Google Scholar 

  • Chan CM, Theng JT, Li L, Tan DT. Microsporidial keratoconjunctivitis in healthy individuals: a case series. Ophthalmology. 2003;110(7):1420–5.

    Article  PubMed  Google Scholar 

  • Corsi A, Nucci C, Knafelz D, Bulgarini D, Di Iorio L, Polito A, De Risi F, Ardenti Morini F, Paone FM. Ocular changes associated with Giardia lamblia infection in children. Br J Ophthalmol. 1998;82(1):59–62.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Coura JR, Borges-Pereira J. Chagas disease: 100 years after its discovery. A systemic review. Acta Trop. 2010;115(1–2):5–13.

    Article  PubMed  Google Scholar 

  • Delair E, Latkany P, Noble AG, Rabiah P, McLeod R, Brézin A. Clinical manifestations of ocular toxoplasmosis. Ocul Immunol Inflamm. 2011;19(2):91–102.

    Article  PubMed  Google Scholar 

  • de-la-Torre A, Stanford M, Curi A, Jaffe GJ, Gomez-Marin JE. Therapy for ocular toxoplasmosis. Ocul Immunol Inflamm. 2011;19(5):314–20.

    Article  PubMed  CAS  Google Scholar 

  • Dias JCP, Coura JR, Yasuda MAS. The present situation, challenges, and perspectives regarding the production and utilization of effective drugs against human Chagas disease. Rev Soc Bras Med Trop. 2014;47(1):123–5.

    Article  PubMed  Google Scholar 

  • Elmahallawy EK, Sampedro Martinez A, Rodriguez-Granger J, Hoyos-Mallecot Y, Agil A, Navarro Mari JM, Gutierrez FJ. Diagnosis of leishmaniasis. J Infect Dev Ctries. 2014;8(8):961–72.

    Article  PubMed  Google Scholar 

  • Fuglsang H, Anderson J. A preliminary trial of nifurtimox in the treatment of onchocerciasis. Tropenmed Parasitol. 1978;29(3):335–8.

    PubMed  CAS  Google Scholar 

  • Garcia-Méric P, Franck J, Dumon H, Piarroux R. Management of congenital toxoplasmosis in France: current data. Presse Med. 2010;39(5):530–8.

    Article  PubMed  Google Scholar 

  • Gaynor BD, Amza A, Kadri B, Nassirou B, Lawan O, Maman L, Stoller NE, Yu SN, Chin SA, West SK, Bailey RL, Rosenthal PJ, Keenan JD, Porco TC, Lietman TM. Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in Niger: a cluster-randomized trial. Am J Trop Med Hyg. 2014;90(5):846–51.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Granados CE, Reveiz L, Uribe LG, Criollo CP. Drugs for treating giardiasis. Cochrane Database Syst Rev. 2012;12:CD007787. doi: 10.1002/14651858.CD007787.pub2.

  • Guldsten H. Clindamycin and sulphonamides in the treatment of ocular toxoplasmosis. Acta Ophthalmol (Copenh). 1983;61(1):51–7.

    Article  CAS  Google Scholar 

  • Harrell M, Carvounis PE. Current treatment of toxoplasma retinochoroiditis: an evidence-based review. J Ophthalmol. 2014;2014:273506.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Heby O, Persson L, Rentala M. Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas’ disease, and leishmaniasis. Amino Acids. 2007;33(2):359–66.

    Article  PubMed  CAS  Google Scholar 

  • Holland GN, Lewis KG. An update on current practices in the management of ocular toxoplasmosis. Am J Ophthalmol. 2002;134:102–14.

    Article  PubMed  Google Scholar 

  • Hosseini SM, Abrishami M, Mehdi ZM. Intravitreal clindamycin in the treatment of unresponsive zone one toxoplasmic chorioretinitis: a case report. Iran Red Crescent Med J. 2014;16(11), e15428.

    Article  PubMed Central  PubMed  Google Scholar 

  • Jennings FW. Chemotherapy of trypanosomiasis: the potentiation of melarsoprol by concurrent difluoromethylornithine (DFMO) treatment. Trans R Soc Trop Med Hyg. 1988;82(4):572–3.

    Article  PubMed  CAS  Google Scholar 

  • Jin KW, Jeon HS, Hyon JY, Wee WR, Suh W, Shin YJ. A case of fungal keratitis and onychomycosis simultaneously infected by Trichophyton species. BMC Ophthalmol. 2014;14:90.

    Article  PubMed Central  PubMed  Google Scholar 

  • Kaye A. Toxoplasmosis: diagnosis, treatment, and prevention in congenitally exposed infants. J Pediatr Health Care. 2011;25(6):355–64.

    Article  PubMed  Google Scholar 

  • Khadem F, Uzonna JE. Immunity to visceral leishmaniasis: implications for immunotherapy. Future Microbiol. 2014;9(7):901–15.

    Article  PubMed  CAS  Google Scholar 

  • Khalil EA, Musa AM, Younis BM, Elfaki ME, Zijlstra EE, Elhassan AM. Blindness following visceral leishmaniasis: a neglected post-kala-azar complication. Trop Doct. 2011;41(3):139–40.

    Article  PubMed  CAS  Google Scholar 

  • Khandelwal SS, Woodward MA, Hall T, Grossniklaus HE, Stulting RD. Treatment of microsporidia keratitis with topical voriconazole monotherapy. Arch Ophthalmol. 2011;129(4):509–10.

    Article  PubMed Central  PubMed  Google Scholar 

  • Khyatti M, Trimbitas RD, Zouheir Y, Benani A, El Messaoudi MD, Hemminki K. Infectious diseases in North Africa and North African immigrants to Europe. Eur J Public Health. 2014;24 Suppl 1:47–56.

    Article  PubMed  Google Scholar 

  • Kowalski RP, Abdel Aziz S, Romanowski EG, Shanks RM, Nau AC, Raju LV. Development of a practical complete-kill assay to evaluate anti-Acanthamoeba drugs. JAMA Ophthalmol. 2013;131(11):1459–62.

    Article  PubMed Central  PubMed  Google Scholar 

  • Kulakova L, Galkin A, Chen CZ, Southall N, Marugan JJ, Zheng W, Herzberg O. Discovery of novel antigiardiasis drug candidates. Antimicrob Agents Chemother. 2014;58(12):7303–11.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Lal A, Baker MG, Hales S, French NP. Potential effects of global environmental changes on cryptosporidiosis and giardiasis transmission. Trends Parasitol. 2013;29(2):83–90.

    Article  PubMed  Google Scholar 

  • Le Loup G, Pialoux G, Lescure FX. Update in treatment of Chagas disease. Curr Opin Infect Dis. 2011;24(5):428–34.

    Article  PubMed  CAS  Google Scholar 

  • Lima e Silva R, Saishin Y, Saishin Y, Akiyama H, Kachi S, Aslam S, Rogers B, Deering T, Gong YY, Hackett SF, Lai H, Frydman BJ, Valasinas A, Marton LJ, Campochiaro PA. Suppression and regression of choroidal neovascularization by polyamine analogues. Invest Ophthalmol Vis Sci. 2005;46(9):3323–30.

    Article  PubMed  Google Scholar 

  • Lin HC, Hsiao CH, Ma DH, Yeh LK, Tan HY, Lin MY, Huang SC. Medical treatment for combined Fusarium and Acanthamoeba keratitis. Acta Ophthalmol. 2009;87(2):199–203.

    Article  PubMed  CAS  Google Scholar 

  • Loh RS, Chan CM, Ti SE, Lim L, Chan KS, Tan DT. Emerging prevalence of microsporidial keratitis in Singapore: epidemiology, clinical features, and management. Ophthalmology. 2009;116(12):2348–53.

    Article  PubMed  Google Scholar 

  • Maenz M, Schlüter D, Liesenfeld O, Schares G, Gross U, Pleyer U. Ocular toxoplasmosis past, present and new aspects of an old disease. Prog Retin Eye Res. 2014;39:77–106.

    Article  PubMed  CAS  Google Scholar 

  • Mahajan R, Das P, Isaakidis P, Sunyoto T, Sagili KD, Lima MA, Mitra G, Kumar D, Pandey K, Van Geertruyden JP, Boelaert M, Burza S. Combination Treatment for Visceral Leishmaniasis Patients Coinfected with Human Immunodeficiency Virus in India. Clin Infect Dis. 2015;61(8):1255–62. doi: 10.1093/cid/civ530. Epub 2015 Jun 30.

    Google Scholar 

  • Manyando C, Njunju EM, D’Alessandro U, Van Geertruyden JP. Safety and efficacy of co-trimoxazole for treatment and prevention of Plasmodium falciparum malaria: a systematic review. PLoS One. 2013;8(2), e56916.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Martín-Navarro CM, López-Arencibia A, Arnalich-Montiel F, Valladares B, Piñero JE, Lorenzo-Morales J. Evaluation of the in vitro activity of commercially available moxifloxacin and voriconazole eye-drops against clinical strains of Acanthamoeba. Graefes Arch Clin Exp Ophthalmol. 2013;251(9):2111–7.

    Article  PubMed  CAS  Google Scholar 

  • Maude RJ, Ahmed BU, Rahman AH, Rahman R, Majumder MI, Menezes DB, Abu Sayeed A, Hughes L, MacGillivray TJ, Borooah S, Dhillon B, Dondorp AM, Faiz MA. Retinal changes in visceral leishmaniasis by retinal photography. BMC Infect Dis. 2014;14:527.

    Article  PubMed Central  PubMed  Google Scholar 

  • Medeiros FPM. Current situation and new perspectives for the treatment of Chagas disease. Prospects for production and distribution of benznidazole. Rev Soc Bras Med Trop. 2009;42(Supl II):79.

    Google Scholar 

  • Meltzer E, Lachish T, Schwartz E. Treatment of giardiasis after nonresponse to nitroimidazole. Emerg Infect Dis. 2014;20(10):1742–4.

    PubMed Central  PubMed  Google Scholar 

  • Mochizuki K, Niwa Y, Ishida K, Kawakami H. Intraocular penetration of itraconazole in patient with fungal endophthalmitis. Int Ophthalmol. 2013;33(5):579–81.

    Article  PubMed  Google Scholar 

  • Molina I, Gómez i Prat J, Salvador F, Treviño B, Sulleiro E, Serre N, Pou D, Roure S, Cabezos J, Valerio L, Blanco-Grau A, Sánchez-Montalvá A, Vidal X, Pahissa A. Randomized trial of posaconazole and benznidazole for chronic Chagas’ disease. N Engl J Med. 2014;370(20):1899–908.

    Article  PubMed  CAS  Google Scholar 

  • Montero JA, Ruiz-Moreno JM, Sanchis E. Intraretinal hemorrhage associated with leishmaniasis. Ophthalmic Surg Lasers Imaging. 2003;34(3):212–4.

    PubMed  Google Scholar 

  • Mørch K, Hanevik K, Robertson LJ, Strand EA, Langeland N. Treatment-ladder and genetic characterisation of parasites in refractory giardiasis after an outbreak in Norway. J Infect. 2008;56(4):268–73.

    Article  PubMed  Google Scholar 

  • Noble A. Cataracts in congenital toxoplasmosis. J AAPOS. 2007;11:551–4.

    Article  PubMed Central  PubMed  Google Scholar 

  • Opremcak EM, Scales DK, Sharpe MR. Trimethoprim-sulfamethoxazole therapy for ocular toxoplasmosis. Ophthalmology. 1992;99(6):920–5.

    Article  PubMed  CAS  Google Scholar 

  • Osadchy A, Ratnapalan T, Koren G. Ocular toxicity in children exposed in utero to antimalarial drugs: review of the literature. J Rheumatol. 2011;38(12):2504–8.

    Article  PubMed  CAS  Google Scholar 

  • Paquet C. Yudin MH; Toxoplasmosis in pregnancy: prevention, screening, and treatment. Society of Obstetricians and Gynaecologists of Canada. J Obstet Gynaecol Can. 2013;35(1):78–81.

    Article  PubMed  Google Scholar 

  • Parchand S, Gupta A, Ram J, Gupta N, Chakrabarty A. Voriconazole for fungal corneal ulcers. Ophthalmology. 2012;119(5):1083.

    Article  PubMed  Google Scholar 

  • Park YH, Nam HW. Clinical features and treatment of ocular toxoplasmosis. Korean J Parasitol. 2013;51(4):393–9.

    Article  PubMed Central  PubMed  Google Scholar 

  • Pasupuleti V, Escobedo AA, Deshpande A, Thota P, Roman Y, Hernandez AV. Efficacy of 5-nitroimidazoles for the treatment of giardiasis: a systematic review of randomized controlled trials. PLoS Negl Trop Dis. 2014;8(3), e2733.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Patole S, Burza S, Varghese GM. Multiple relapses of visceral leishmaniasis in a patient with HIV in India: a treatment challenge. Int J Infect Dis. 2014;25:204–6.

    Article  PubMed  Google Scholar 

  • Pfaff AW, de-la-Torre A, Rochet E, Brunet J, Sabou M, Sauer A, Bourcier T, Gomez-Marin JE, Candolfi E. New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis. Int J Parasitol. 2014;44(2):99–107.

    Article  PubMed  CAS  Google Scholar 

  • Pinazo MJ, Espinosa G, Gállego M, et al. Successful treatment with posaconazole of a patient with chronic Chagas disease and systemic lupus erythematosus. Am J Trop Med Hyg. 2010;82:583–7.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Pleyer U, Schlüter D, Mänz M. Ocular toxoplasmosis: recent aspects of pathophysiology and clinical implications. Ophthalmic Res. 2014;52(3):116–23.

    Article  PubMed  Google Scholar 

  • Priotto G, Kasparian S, Mutombo W, Ngouama D, Ghorashian S, Arnold U, Ghabri S, Baudin E, Buard V, Kazadi-Kyanza S, Ilunga M, Mutangala W, Pohlig G, Schmid C, Karunakara U, Torreele E, Kande V. Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial. Lancet. 2009;374(9683):56–64.

    Article  PubMed  CAS  Google Scholar 

  • Rodgers J, Jones A, Gibaud S, Bradley B, McCabe C, Barrett MP, Gettinby G, Kennedy PG. Melarsoprol cyclodextrin inclusion complexes as promising oral candidates for the treatment of human African trypanosomiasis. PLoS Negl Trop Dis. 2011;5(9), e1308.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Roizenblatt J. Interstitial keratitis caused by American (mucocutaneous) leishmaniasis. Am J Ophthalmol. 1979;87(2):175–9.

    Article  PubMed  CAS  Google Scholar 

  • Rossi P, Urbani C, Donelli G, Pozio E. Resolution of microsporidial sinusitis and keratoconjunctivitis by itraconazole treatment. Am J Ophthalmol. 1999;127(2):210–2.

    Article  PubMed  CAS  Google Scholar 

  • Sadeghian G, Nilfroushzadeh MA, Moradi SH, Hanjani SH. Ocular leishmaniasis: a case report. Dermatol Online J. 2005;11(2):19.

    PubMed  CAS  Google Scholar 

  • Santamaria C, Chatelain E, Jackson Y, Miao Q, Ward BJ, Chappuis F, Ndao M. Serum biomarkers predictive of cure in Chagas disease patients after nifurtimox treatment. BMC Infect Dis. 2014;14:302.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Shea B. Folic acid or folinic acid for reducing side effects of methotrexate for people with rheumatoid arthritis. J Evid Based Med. 2013;6(3):202–3.

    Article  PubMed  Google Scholar 

  • Sindermann H, Engel J. Development of miltefosine as an oral treatment for leishmaniasis. Trans R Soc Trop Med Hyg. 2006;100 Suppl 1:S17–20.

    Article  PubMed  CAS  Google Scholar 

  • Soheilian M, Ramezani A, Azimzadeh A, et al. Randomized trial of intravitreal clindamycin and dexamethasone versus pyrimethamine, sulfadiazine, and prednisolone in treatment of ocular toxoplasmosis. Ophthalmology. 2011;118(1):134–41.

    Article  PubMed  Google Scholar 

  • Sridhar MS, Sharma S. Microsporidial keratoconjunctivitis in a HIV-seronegative patient treated with debridement and oral itraconazole. Am J Ophthalmol. 2003;136(4):745–6.

    Article  PubMed  CAS  Google Scholar 

  • Stover KR, Riche DM, Gandy CL, Henderson H. What would we do without metronidazole? Am J Med Sci. 2012;343(4):316–9.

    Article  PubMed  Google Scholar 

  • Sunada A, Kimura K, Nishi I, Toyokawa M, Ueda A, Sakata T, Suzuki T, Inoue Y, Ohashi Y, Asari S, Iwatani Y. In vitro evaluations of topical agents to treat Acanthamoeba keratitis. Ophthalmology. 2014;121(10):2059–65.

    Article  PubMed  Google Scholar 

  • Sundar S, Chakravarty J, Agarwal D, Rai M, Murray HW. Single-dose liposomal amphotericin B for visceral leishmaniasis in India. N Engl J Med. 2010;362(6):504–12.

    Article  PubMed  CAS  Google Scholar 

  • Sundar S, Chakravarty J. An update on pharmacotherapy for leishmaniasis. Expert Opin Pharmacother. 2015;16(2):237–52.

    Article  PubMed Central  PubMed  CAS  Google Scholar 

  • Sundar S, Sinha PK, Rai M, Verma DK, Nawin K, Alam S, Chakravarty J, Vaillant M, Verma N, Pandey K, Kumari P, Lal CS, Arora R, Sharma B, Ellis S, Strub-Wourgaft N, Balasegaram M, Olliaro P, Das P, Modabber F. Comparison of short-course multidrug treatment with standard therapy for visceral leishmaniasis in India: an open-label, non-inferiority, randomised controlled trial. Lancet. 2011;377(9764):477–86.

    Article  PubMed  CAS  Google Scholar 

  • Tate Jr GW, Martin RG. Clindamycin in the treatment of human ocular toxoplasmosis. Can J Ophthalmol. 1977;12(3):188–95.

    PubMed  Google Scholar 

  • Taylor WR, Richie TL, Fryauff DJ, Picarima H, Ohrt C, Tang D, Braitman D, Murphy GS, Widjaja H, Tjitra E, Ganjar A, Jones TR, Basri H, Berman J. Malaria prophylaxis using azithromycin: a double-blind, placebo-controlled trial in Irian Jaya, Indonesia. Clin Infect Dis. 1999;28(1):74–81.

    Article  PubMed  CAS  Google Scholar 

  • Tu EY, Joslin CE, Shoff ME. Successful treatment of chronic stromal acanthamoeba keratitis with oral voriconazole monotherapy. Cornea. 2010;29(9):1066–8.

    Article  PubMed Central  PubMed  Google Scholar 

  • Turnbull AM, Lin Z, Matthews BN. Severe bilateral anterior uveitis secondary to giardiasis, initially misdiagnosed as a side effect of metronidazole. Eye (Lond). 2013;27(10):1225–6.

    Article  CAS  Google Scholar 

  • Vedula SS, Nguyen QD. Corticosteroids for ocular toxoplasmosis. Cochrane Database Syst Rev. 2008;4:CD007417.

    Google Scholar 

  • Walochnik J, Obwaller A, Gruber F, Mildner M, Tschachler E, Suchomel M, Duchêne M, Auer H. Anti-acanthamoeba efficacy and toxicity of miltefosine in an organotypic skin equivalent. J Antimicrob Chemother. 2009;64(3):539–45.

    Article  PubMed  CAS  Google Scholar 

  • Winterhalter S, Severing K, Stammen J, Maier AK, Godehardt E, Joussen AM. Does atovaquone prolong the disease-free interval of toxoplasmic retinochoroiditis? Graefes Arch Clin Exp Ophthalmol. 2010;248(8):1187–92.

    Article  PubMed  CAS  Google Scholar 

  • Wolf A, Boulliat C, Coillot C, Rouault M, Gaillard K, Beranger C, Oliver M. Nifurtimox, a bright future for treatment of Chagas disease. Med Trop (Mars). 2011;71(2):131–3.

    CAS  Google Scholar 

  • Yaghoobi R, Maraghi S, Bagherani N, Rafiei A. Cutaneous leishmaniasis of the lid: a report of nine cases. Korean J Ophthalmol. 2010;24(1):40–3.

    Article  PubMed Central  PubMed  Google Scholar 

  • Yazici A, Ozdal PC, Taskintuna I, Kavuncu S, Koklu G. Trimethoprim/Sulfamethoxazole and azithromycin combination therapy for ocular toxoplasmosis. Ocul Immunol Inflamm. 2009;17(4):289–91.

    Article  PubMed  CAS  Google Scholar 

  • Yusuf IH, Sahare P, Hildebrand GD. DRESS syndrome in a child treated for toxoplasma retinochoroiditis. J AAPOS. 2013;17(5):521–3.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Cornea Services, Dr. Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India

    Namrata Sharma MD, Neelima Aron & Tushar Agarwal

  2. Department of Internal Medicine, College of Medicine and Health Sciences, UAE University, Al-Ain, UAE

    Charu Sharma PhD

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  1. Ocular Pharmacology and Pharmacy, Dr. RP Centre for Ophthalmic Sciences, New Delhi, India

    Thirumurthy Velpandian

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Sharma, N., Aron, N., Agarwal, T., Sharma, C. (2016). Antimicrobial Agents for Ocular Use: Bacterial, Fungal, Viral, and Protozoal Infections. In: Velpandian, T. (eds) Pharmacology of Ocular Therapeutics. Adis, Cham. https://doi.org/10.1007/978-3-319-25498-2_11

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