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Regulation of Na+-K+-ATPase in Pulmonary Vasculature

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Regulation of Membrane Na+-K+ ATPase

Part of the book series: Advances in Biochemistry in Health and Disease ((ABHD,volume 15))

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Abstract

Na+-K+-ATPase plays important role in maintaining pulmonary vascular tone as well as homoeostasis. Two different isoforms of Na+-K+-ATPase has been identified in ovine pulmonary artery. α-1 subunit of Na+-K+-ATPase is responsible for the regulation of basal tone of pulmonary artery in sheep. Arachidonic acid inhibits Na+-K+-ATPase in ovine pulmonary artery via 20-HETE production and protein kinase C pathway. Whereas, lipoxygenase has a secondary role in arachidonic acid-induced inhibition of Na+-K+-ATPase in this particular vasculature. BAY 41-2272 a NO-independent activator of sGC induces cGMP-independent vasodilation of sheep pulmonary artery through stimulation of sodium pump which is the primary target for the vasodilation of this vasculature. Eicosapentaenoic acid inhibits functional Na+-K+-ATPase through decrease in the protein expression of the α-1 subunit of sodium pump in pulmonary artery but this attenuation is independent of cGMP production. Sodium nitroprusside induced vasodilation is the result of the link between increased intracellular cGMP and activated sarcolemmal Na+-K+-ATPase in canine pulmonary arterial smooth muscle cells. High salt diet leads to electrical changes in rat pulmonary artery which may be due to the opening of K+ channels and activation of sodium pump. H2O2, xanthine, and xanthine oxidase stimulate sodium pump activity of bovine pulmonary arterial endothelial cells. Regulation of sodium pump expression or activity and trafficking occurs by activation of dopamine receptors in various tissues including lungs and vascular beds. In conclusion, Na+-K+-ATPase is regulated in pulmonary vasculature of different species like ovine, canine, bovine and human by different signaling pathways.

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Authors and Affiliations

  1. Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly, 243122, Uttar Pradesh, India

    Thakur Uttam Singh, Subhashree Parida & Santosh Kumar Mishra

Authors
  1. Thakur Uttam Singh
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  2. Subhashree Parida
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  3. Santosh Kumar Mishra
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Correspondence to Thakur Uttam Singh .

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Editors and Affiliations

  1. Biochemistry and Biophysics, University of Kalyani, Kalyani, West Bengal, India

    Sajal Chakraborti

  2. University of Manitoba, Institute of Cardiovascular Science St. Boniface Hospital Research, Winnipeg, Manitoba, Canada

    Naranjan S Dhalla

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Singh, T.U., Parida, S., Mishra, S.K. (2016). Regulation of Na+-K+-ATPase in Pulmonary Vasculature. In: Chakraborti, S., Dhalla, N. (eds) Regulation of Membrane Na+-K+ ATPase. Advances in Biochemistry in Health and Disease, vol 15. Springer, Cham. https://doi.org/10.1007/978-3-319-24750-2_20

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