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Neuropsychiatric Systemic Lupus Erythematosus

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Connective Tissue Disease

Part of the book series: Rare Diseases of the Immune System ((RDIS))

Abstract

Neuropsychiatric symptoms affect up to half of the patients with SLE. The effect on disease severity, quality of life, and prognosis is extremely heterogeneous. Symptoms of neuropsychiatric SLE (NPSLE) range from mild diffuse conditions to acute life-threatening events. Although the underlying mechanisms are still largely unraveled, several pathogenic pathways have been identified, such as antibody-mediated neurotoxicity, vasculopathy due aPL, and cytokine-induced neurotoxicity.

The chapter focuses on the central nervous system manifestations of NPSLE, with special emphasis on classification, diagnostic, and treatment aspects.

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Authors and Affiliations

  1. Lupus Research Unit, Division of Women’s Health, The Rayne Institute, King’s College London, London, SE17EH, UK

    Karen Schreiber

  2. Department of Rheumatology, Rigshospitalet, Blegdamsvej 9, Copenhagen, DL-2100, Denmark

    Karen Schreiber & Soren Jacobsen

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  1. Karen Schreiber
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  2. Soren Jacobsen
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Correspondence to Soren Jacobsen .

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Editors and Affiliations

  1. Giovanni Bosco Hospital, Center of Immunopathology/Rare Dise, Torino, Torino, Italy

    Dario Roccatello

  2. University of Florence, Florence, Italy

    Lorenzo Emmi

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Schreiber, K., Jacobsen, S. (2016). Neuropsychiatric Systemic Lupus Erythematosus. In: Roccatello, D., Emmi, L. (eds) Connective Tissue Disease. Rare Diseases of the Immune System. Springer, Cham. https://doi.org/10.1007/978-3-319-24535-5_9

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