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Hypofractionated Regional Nodal Irradiation for Breast Cancer

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Abstract

Research from the 1950s and 1960s out of the UK and Australia pioneered work in hypofractionated RNI for breast cancer but resulted in unacceptable toxicity given their limited knowledge of radiobiology [1–4]. The 1970s and 1980s brought us well-known randomized (postmastectomy radiation therapy) PMRT data from Canada and the development of the UK Start trials, both revealing safe delivery of hypofractionated RNI for breast cancer after chemotherapy [5, 6]. The 1990s and 2000s include a follow-on UK Start trial, as well as several small prospective trials from Pakistan, Greece, and Belgium, all demonstrating safe hypofractionated RNI for breast cancer [7–10].

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Authors and Affiliations

  1. Department of Radiation Oncology, Huntsman Cancer Hospital, University of Utah, Salt Lake City, UT, USA

    Matthew Poppe MD

  2. Department of Radiation Oncology, Summa Health System, Akron, OH, USA

    Chirag Shah MD

  3. Department of Radiation Oncology, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA

    Atif J. Khan MD

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  1. Matthew Poppe MD
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  2. Chirag Shah MD
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  3. Atif J. Khan MD
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Correspondence to Matthew Poppe MD .

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Editors and Affiliations

  1. Department of Radiation Oncology, Virginia Commonwealth Univ Sch. Medicine Department of Radiation Oncology, RICHMOND, Virginia, USA

    Douglas W Arthur

  2. Michigan Healthcare Professionals, 21st Century Oncology Michigan Healthcare Professionals, Farmington Hills, Michigan, USA

    Frank A. Vicini

  3. Dept. Rad Oncol, Tufts Univ. School Med, Alpert Medical School Brown University Dept. Rad Oncol, Tufts Univ. School Med, BOSTON, Massachusetts, USA

    David E. Wazer

  4. Dept. of Radiation Oncology, Rutgers Can State Univ. New Jer Sch. Med Dept. of Radiation Oncology, NEW BRUNSWICK, New Jersey, USA

    Atif J. Khan

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Poppe, M., Shah, C., Khan, A.J. (2016). Hypofractionated Regional Nodal Irradiation for Breast Cancer. In: Arthur, D., Vicini, F., Wazer, D., Khan, A. (eds) Short Course Breast Radiotherapy. Springer, Cham. https://doi.org/10.1007/978-3-319-24388-7_28

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