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microRNA and Lung Cancer

  • Chapter
microRNA: Cancer

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 889))

Abstract

Lung cancer is the leading cause of cancer mortality worldwide. microRNAs (miRNAs) have been established as players with a relevant role in lung cancer development, epithelial–mesenchymal transition and response to therapy. Additionally, in the last decade, miRNAs, measured in resected tumor samples or in fine-needle aspirate samples have emerged as compelling biomarkers for tumor diagnosis, prognosis, and prediction of response to treatment, due to the ease of their detection and in their extreme specificity. Moreover, miRNAs present in sputum, in plasma, in serum or in whole-blood have increasingly been explored in the last 5 years as less invasive biomarkers for the early detection of cancers.

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  1. Laboratory of RNA Biology and Biotechnology, Centre for Integrative Biology, University of Trento, via Sommarive 9, Trento, 38123, Italy

    Valerio Del Vescovo & Michela A. Denti

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  1. Valerio Del Vescovo
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  2. Michela A. Denti
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Correspondence to Michela A. Denti .

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  1. Department of Physiology, Columbia University Medical Center, New York, New York, USA

    Gaetano Santulli

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Vescovo, V.D., Denti, M.A. (2015). microRNA and Lung Cancer. In: Santulli, G. (eds) microRNA: Cancer. Advances in Experimental Medicine and Biology, vol 889. Springer, Cham. https://doi.org/10.1007/978-3-319-23730-5_9

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