Skip to main content
SpringerLink
Log in

Juvenile Nasopharyngeal Angiofibroma (JNA)

  • Chapter
Atlas of Sellar and Parasellar Lesions

Abstract

Juvenile nasopharyngeal angiofibroma (JNA) is a rare, histologically benign skull base tumor that develops in adolescents and young adults, almost exclusively in males.

JNAs represent less than 1 % of head and neck tumors.

The median age at diagnosis is 15 years.

The incidence rate of JNA is 0.4 per million persons per year and as high as 3.7 per million males per year.

Patients typically present with epistaxis and nasal obstruction.

JNA may be related to familial adenomatous polyposis (FAP).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Cherekaev VA, Golbin DA, Kapitanov DN, Roginsky VV, Yakovlev SB, Arustamian SR. Advanced craniofacial juvenile nasopharyngeal angiofibroma. Description of surgical series, case report, and review of literature. Acta Neurochir (Wien). 2011;153:499–508.

    Article  Google Scholar 

  2. Witt TR, Shah JP, Sternberg SS. Juvenile nasopharyngeal angiofibroma. A 30 year clinical review. Am J Surg. 1983;146:521–5.

    Article  CAS  PubMed  Google Scholar 

  3. Glad H, Vainer B, Buchwald C, Petersen BL, Theilgaard SA, Bonvin P, et al. Juvenile nasopharyngeal angiofibromas in Denmark 1981–2003: diagnosis, incidence, and treatment. Acta Otolaryngol. 2007;127:292–9.

    Article  CAS  PubMed  Google Scholar 

  4. Valanzano R, Curia MC, Aceto G, Veschi S, De Lellis L, Catalano T, et al. Genetic evidence that juvenile nasopharyngeal angiofibroma is an integral FAP tumour. Gut. 2005;54:1046–7.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  5. Lloyd G, Howard D, Lund VJ, Savy L. Imaging for juvenile angiofibroma. J Laryngol Otol. 2000;114:727–30.

    CAS  PubMed  Google Scholar 

  6. Lloyd G, Howard D, Phelps P, Cheesman A. Juvenile angiofibroma: the lessons of 20 years of modern imaging. J Laryngol Otol. 1999;113:127–34.

    CAS  PubMed  Google Scholar 

  7. Nicolai P, Villaret AB, Farina D, Nadeau S, Yakirevitch A, Berlucchi M, Galtelli C. Endoscopic surgery for juvenile angiofibroma: a critical review of indications after 46 cases. Am J Rhinol Allergy. 2010;24:e67–72.

    Article  PubMed  Google Scholar 

  8. Chandler JR, Goulding R, Moskowitz L, Quencer RM. Nasopharyngeal angiofibromas: staging and management. Ann Otol Rhinol Laryngol. 1984;93:322–9.

    Article  CAS  PubMed  Google Scholar 

  9. Pauli J, Gundelach R, Vanelli-Rees A, Rees G, Campbell C, Dubey S, Perry C. Juvenile nasopharyngeal angiofibroma: an immunohistochemical characterisation of the stromal cell. Pathology. 2008;40:396–400.

    Article  CAS  PubMed  Google Scholar 

  10. Boghani Z, Husain Q, Kanumuri VV, Khan MN, Sangvhi S, Liu JK, Eloy JA. Juvenile nasopharyngeal angiofibroma: a systematic review and comparison of endoscopic, endoscopic-assisted, and open resection in 1047 cases. Laryngoscope. 2013;123:859–69.

    Article  PubMed  Google Scholar 

  11. Zanation AM, Mitchell CA, Rose AS. Endoscopic skull base techniques for juvenile nasopharyngeal angiofibroma. Otolaryngol Clin North Am. 2012;45:711–30.

    Article  PubMed  Google Scholar 

  12. Leong SC. A systematic review of surgical outcomes for advanced juvenile nasopharyngeal angiofibroma with intracranial involvement. Laryngoscope. 2013;123:1125–31.

    Article  PubMed  Google Scholar 

  13. Gates GA, Rice DH, Koopmann Jr CF, Schuller DE. Flutamide-induced regression of angiofibroma. Laryngoscope. 1992;102:641–4.

    Article  CAS  PubMed  Google Scholar 

  14. Gullane PJ, Davidson J, O’Dwyer T, Forte V. Juvenile angiofibroma: a review of the literature and a case series report. Laryngoscope. 1992;102:928–33.

    Article  CAS  PubMed  Google Scholar 

  15. Kasper ME, Parsons JT, Mancuso AA, Mendenhall WM, Stringer SP, Cassisi NJ, Million RR. Radiation therapy for juvenile angiofibroma: evaluation by CT and MRI, analysis of tumor regression, and selection of patients. Int J Radiat Oncol Biol Phys. 1993;25:689–94.

    Article  CAS  PubMed  Google Scholar 

  16. Lee JT, Chen P, Safa A, Juillard G, Calcaterra TC. The role of radiation in the treatment of advanced juvenile angiofibroma. Laryngoscope. 2002;112:1213–20.

    Article  PubMed  Google Scholar 

  17. Reddy KA, Mendenhall WM, Amdur RJ, Stringer SP, Cassisi NJ. Long-term results of radiation therapy for juvenile nasopharyngeal angiofibroma. Am J Otolaryngol. 2001;22:172–5.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurological Surgery, Keck School of Medicine, University of Southern California, 1200 N State Street, #3300, Los Angeles, CA, 90033, USA

    Gabriel Zada MD, MS

  2. Department of Pathology (Neuropathology), University of Virginia School of Medicine, 1215 Lee Street, Room 3060–HEP, Charlottesville, VA, 22908, USA

    M. Beatriz S. Lopes MD, PhD

  3. Department of Radiology, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA, 02115, USA

    Srinivasan Mukundan Jr. PhD, MD

  4. Department of Neurosurgery, Brigham and Women’s Hospital, 15 Francis Street, Boston, MA, 02115, USA

    Edward Laws Jr. MD

Authors
  1. Gabriel Zada MD, MS
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Beatriz S. Lopes MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Srinivasan Mukundan Jr. PhD, MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Edward Laws Jr. MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Gabriel Zada MD, MS .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, University of Southern California, LOS ANGELES, California, USA

    Gabriel Zada

  2. Department of Pathology, University of Virginia, CHARLOTTESVILLE, Virginia, USA

    M. Beatriz S. Lopes

  3. Department of Radiology, Brigham and Women's Hospital, BOSTON, Massachusetts, USA

    Srinivasan Mukundan Jr.

  4. Department of Neurosurgery, Brigham and Women’s Hospital, BOSTON, Massachusetts, USA

    Edward R. Laws Jr.

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Zada, G., Lopes, M.B.S., Mukundan, S., Laws, E. (2016). Juvenile Nasopharyngeal Angiofibroma (JNA). In: Zada, G., Lopes, M., Mukundan Jr., S., Laws Jr., E. (eds) Atlas of Sellar and Parasellar Lesions. Springer, Cham. https://doi.org/10.1007/978-3-319-22855-6_49

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-22855-6_49

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-22854-9

  • Online ISBN: 978-3-319-22855-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation