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microRNAs and Personalized Medicine: Evaluating Their Potential as Cancer Biomarkers

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microRNA: Medical Evidence

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 888))

Abstract

microRNA deregulations are often, if not invariably, associated with human malignancies, including cancers. Though most of these deregulations may not be functionally implicated in tumorigenesis, the fact that microRNA expression can be monitored in a variety of human specimens, including biological fluids, supports studies aimed at characterizing microRNA signatures able to detect various cancers (diagnosis), predict their outcome (prognosis), monitor their treatment (theranosis), and adapt therapy to a patient (precision medicine). Here, we review and discuss pros and cons of microRNA-based approaches that can support their exploitation as cancer biomarkers.

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Authors and Affiliations

  1. University of Montpellier, 163 rue Auguste Broussonnet, Montpellier, 34090, France

    Anne Saumet M.Sc., Ph.D. & Charles-Henri Lecellier M.Sc., Ph.D.

  2. Faculty of Medicine, 2 rue de l’Ecole de Médecine, Montpellier, 34060, France

    Anne Saumet M.Sc., Ph.D.

  3. Institute of Molecular Genetics of Montpellier, CNRS UMR 5535, 1919 Route de Mende, Montpellier, 34293, France

    Charles-Henri Lecellier M.Sc., Ph.D.

  4. Computational Biology Institute, 860 rue de Saint Priest, Montpellier, 34095, France

    Charles-Henri Lecellier M.Sc., Ph.D.

Authors
  1. Anne Saumet M.Sc., Ph.D.
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  2. Charles-Henri Lecellier M.Sc., Ph.D.
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Correspondence to Charles-Henri Lecellier M.Sc., Ph.D. .

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  1. Columbia University Medical Center, New York, New York, USA

    Gaetano Santulli

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Saumet, A., Lecellier, CH. (2015). microRNAs and Personalized Medicine: Evaluating Their Potential as Cancer Biomarkers. In: Santulli, G. (eds) microRNA: Medical Evidence. Advances in Experimental Medicine and Biology, vol 888. Springer, Cham. https://doi.org/10.1007/978-3-319-22671-2_2

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