Abstract
The pathologist’s role in the context of precision medicine integrates samples preparation for nucleic acids extractions together with pathological analysis, a mandatory step before molecular analyses. The morphological and phenotypical diagnosis contributes to the appropriate interpretation of the identified molecular alterations providing the exact nature of the tumor, the tumoral cellularity of the analyzed sample useful to interpret molecular alterations such as alternative allele frequency. In some circumstances, genomic alterations require to be validated at the protein level using immunohistochemistry expression.
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Le Tourneau C, Mitry E, Goncalves A et al (2014) Randomized phase II trial comparing therapy based on tumor molecular profiling versus conventional therapy in patients with refractory cancer: results of the feasibility part of the SHIVA trial. Br J Cancer 111:17–24
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© 2015 Springer International Publishing Switzerland
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Vincent-Salomon, A. (2015). The Key Role of Pathology in the Context of Precision Medicine Trials. In: Le Tourneau, C., Kamal, M. (eds) Pan-cancer Integrative Molecular Portrait Towards a New Paradigm in Precision Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-22189-2_2
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DOI: https://doi.org/10.1007/978-3-319-22189-2_2
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-22188-5
Online ISBN: 978-3-319-22189-2
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