Abstract
Duchenne muscular dystrophy (DMD) is caused by a mutation of the dystrophin gene. The progressive reduction in forced vital capacity predicts the development of respiratory failure, which evolves from nocturnal to daytime hypercapnia until the occurrence of respiratory symptoms. Treatment of pulmonary complications with noninvasive ventilatory support may improve quality of life and reduce the high morbidity, as well as early mortality, associated with DMD.
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Abbreviations
- DMD:
-
Duchenne muscular dystrophy
- FVC:
-
Forced vital capacity
- IPAP:
-
Inspiratory positive airway pressures
- PaCO2 :
-
Arterial partial pressure of CO2
- REM:
-
Rapid eye movement
- RR:
-
Respiratory rate
- SDB:
-
Sleep disordered breathing
- VC:
-
Vital capacity
- VT :
-
Tidal volume
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Fiorentino, G., Pisano, A., Annunziata, A. (2016). Noninvasive Mechanical Ventilation in Duchenne Muscular Dystrophy: What Have We Learned?. In: Esquinas, A. (eds) Noninvasive Mechanical Ventilation. Springer, Cham. https://doi.org/10.1007/978-3-319-21653-9_39
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DOI: https://doi.org/10.1007/978-3-319-21653-9_39
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-21652-2
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