Abstract
JAK Janus kinases (JAKs) are a group of intracellular tyrosine kinases that play an essential role in controlling cellular activities in response to extracellular cytokines. In mammals, the JAK family comprises four members: JAK1, JAK2, JAK3 and Tyk2 (tyrosine kinase 2). Inhibition of JAK activity has therapeutic application in the treatment of inflammatory diseases and cancer.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Rovenský, J., Payer, J., Herold, M. (2016). J. In: Rovenský, J., Payer, J., Herold, M. (eds) Dictionary of Rheumatology. Springer, Cham. https://doi.org/10.1007/978-3-319-21335-4_10
Download citation
DOI: https://doi.org/10.1007/978-3-319-21335-4_10
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-21334-7
Online ISBN: 978-3-319-21335-4
eBook Packages: MedicineMedicine (R0)