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Lung Vasculogenesis and Angiogenesis

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Stem Cells in the Lung

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

The pulmonary vasculature remains the poor cousin of lung development. Evidence has challenged old notions that the development of blood vessels in the lung passively follows that of the airways. Rather, lung blood vessels actively promote alveolar growth during development and contribute to the maintenance of alveolar structures throughout postnatal life. These observations may be relevant for lung diseases characterized by arrested alveolar growth or loss of alveoli. This review summarizes the role of angiogenic growth factors during normal alveolar development, injury, and repair and identifies gaps in our understanding of lung vasculogenesis and angiogenesis.

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Acknowledgments

B.T. is supported by the Canadian Institutes for Health Research (CIHR), the Ontario Thoracic Society, the Canadian Stem Cell Network, the Children’s Hospital of Eastern Ontario Research Institute and the Ottawa Hospital Research Institute. M.Y. is supported in part by the Riley Children’s Foundation.

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Authors and Affiliations

  1. Division of Neonatology, Department of Pediatrics, Sinclair Centre for Regenerative Medicine, Ottawa Hospital Research Institute, Children’s Hospital of Eastern Ontario, University of Ottawa, 501 Smyth Road, Ottawa, ON, Canada, K1H 8L6

    Bernard Thébaud

  2. Department of Pediatrics, Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA

    Mervin C. Yoder

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  1. Bernard Thébaud
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  2. Mervin C. Yoder
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Correspondence to Bernard Thébaud .

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  1. Lung Health Research Centre, Department of Pharmacology and Therapeutics, University of Melbourne, Melbourne, Victoria, Australia

    Ivan Bertoncello

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Thébaud, B., Yoder, M.C. (2015). Lung Vasculogenesis and Angiogenesis. In: Bertoncello, I. (eds) Stem Cells in the Lung. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-21082-7_3

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