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Cellular Origins of Fibrotic Lung Diseases

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Stem Cells in the Lung

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Fibrosis of the lung is a final end point of a variety of pathologic processes targeting the lung, ranging from allo- and autoimmune diseases to occupational lung exposures. Fibrosis entails loss of somatic cell populations such as epithelial cells from their anatomic location along with proliferation, mobilization, infiltration, and differentiation of mesenchymal cells. In this chapter, I will review the present knowledge of the role of various resident progenitor cell populations in the origin of fibrotic lung diseases. Specifically, the origin of myofibroblasts in human fibrotic lungs is addressed.

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  1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, 48109, USA

    Vibha N. Lama

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Correspondence to Vibha N. Lama .

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  1. Lung Health Research Centre, Department of Pharmacology and Therapeutics, University of Melbourne, Melbourne, Victoria, Australia

    Ivan Bertoncello

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Lama, V.N. (2015). Cellular Origins of Fibrotic Lung Diseases. In: Bertoncello, I. (eds) Stem Cells in the Lung. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-21082-7_13

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