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Diabetes and Liver Disease

Principles of Diabetes Mellitus

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Abstract

The prevalence of diabetes is rising in the United States, with a similar increase in associated complications. Diabetes has significant deleterious effects on many organ systems including the liver. Hepatic complications include the development of nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, hepatocellular carcinoma, liver failure, and the onset of diabetes following liver transplantation. There is significant morbidity and mortality associated with these conditions. Understanding the clinical characteristics and pathophysiology of diabetes related liver disease affords care providers an opportunity to prevent, monitor, and treat these complications. In order to successfully impact clinical outcomes the specific treatment of hepatic disorders must be coordinated with the management of underlying diabetes. While limited treatments currently exist, new therapeutic modalities are being developed that target insulin resistance, cytokine induced injury, and fatty acid metabolism.

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  1. Division of Hepatology, Northwell Health System, Hofstra Northwell School of Medicine, Manhasset, NY, USA

    Robert Hirten, Henry C. Bodenheimer Jr. & David Bernstein

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  2. Henry C. Bodenheimer Jr.
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  1. Lenox Hill Hospital Division of Endocrinology, New York, New York, USA

    Leonid Poretsky

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Hirten, R., Bodenheimer, H.C., Bernstein, D. (2015). Diabetes and Liver Disease. In: Poretsky, L. (eds) Principles of Diabetes Mellitus. Springer, Cham. https://doi.org/10.1007/978-3-319-20797-1_35-1

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  1. Latest

    Diabetes and Liver Disease
    Published:
    26 November 2019

    DOI: https://doi.org/10.1007/978-3-319-20797-1_35-2

  2. Original

    Diabetes and Liver Disease
    Published:
    17 February 2016

    DOI: https://doi.org/10.1007/978-3-319-20797-1_35-1

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