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Response of Cupriavidus metallidurans CH34 to Metals

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Metal Response in Cupriavidus metallidurans

Part of the book series: SpringerBriefs in Molecular Science ((SB BIOMETALS))

Abstract

Cupriavidus metallidurans CH34 displays resistance to a plethora of metals. Its response and underlying genetic determinants are dissected and detailed metal by metal (from arsenic to zinc). An important role for its megaplasmids pMOL28 and pMOL30 is shown, with high level resistance to cadmium, chromate, cobalt, copper, mercury, nickel, lead and zinc mediated by well-known genes for detoxification that are often accompanied by other functions linked to acute or chronic stress. Nevertheless, metal resistance determinants are also found on the chromid (e.g. to chromate, copper and zinc) as well as on a large genomic island integrated in the chromosome (e.g. to cadmium, lead and mercury). Even the core genome participates in certain responses such as to gold or selenium. Next, we summarized the environmental applications, which were developed based on the knowledge gained by studying these different determinants, and in particular biosensors and soil and water bioremediation. Finally, the general transcriptional response of C. metallidurans to sixteen different metals supplied at different concentrations (including acute stress) is discussed within the framework of its intricate regulatory network.

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Notes

  1. 1.

    ScanProsite (de Castro et al. 2006) detected 119 protein sequences with at least 2 hits for the {M-Q-G-M-D} motif on all UniProtKB/TrEMBL (release 2014_05 of 14-May-2014: 56010222 entries) database sequences.

  2. 2.

    For a general evaluation of the microbial reporters designed to assay metal bioavailability and their possible use in environmental remediation see Magrisso et al. (2008).

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  1. Unit of Microbiology, Belgian Nuclear Research Centre (SCK•CEN), Mol, Belgium

    Pieter Monsieurs, Max Mergeay & Rob Van Houdt

  2. School of Biosciences, The University of Nottingham, Sutton Bonington Campus, Sutton Bonington, LE12 5RD, UK

    Jon Hobman

  3. Laboratory for the Structure and Function of Biological Membranes, Center for Structural Biology and Bioinformatics, Université Libre de Bruxelles, Brussels, Belgium

    Guy Vandenbussche

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    Max Mergeay

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Monsieurs, P., Hobman, J., Vandenbussche, G., Mergeay, M., Van Houdt, R. (2015). Response of Cupriavidus metallidurans CH34 to Metals. In: Mergeay, M., Van Houdt, R. (eds) Metal Response in Cupriavidus metallidurans. SpringerBriefs in Molecular Science(). Springer, Cham. https://doi.org/10.1007/978-3-319-20594-6_3

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