Abstract
Paraneoplastic retinopathy is a syndrome where one’s immune system response to a tumor leads to generation of antibodies to the tumor antigen that cross-reacts with retinal proteins. These autoantibodies to the retina lead to rod and cone photoreceptor dysfunction. There are several classifications of paraneoplastic retinopathies; we discuss the three most common types carcinoma-associated retinopathy, melanoma-associated retinopathy, and bilateral diffuse uveal melanocytic proliferation.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References and Suggested Reading
Hecklenlively JR, Ferreyra HA. Autoimmune retinopathy: a review and summary. Semin Immunopathol. 2008;30:127–34.
Keltner JL, Roth AM, Chang S. Photoreceptor degeneration – a possible autoimmune disease. Arch Ophthalmol. 1983;101:564–9.
Ferreyra HA, Jayasundera T, Kahn NW, et al. Management of autoimmune retinopathies with immunosuppression. Arch Ophthalmol. 2009;127(4):390–7.
Chan JW. Paraneoplastic retinopathies and optic neuropathies. Surv Ophthalmol. 2003;48(1):12–38.
Courtney RJ, Singh RP, Aronow MB, Singh AD. Ocular paraneoplastic diseases. In: Singh AD, Damato BE, editors. Retinal tumors. Clinical ophthalmic oncology. Heidelberg: Springer; 2015. p. 133–52.
Singh AD, Rundle PA, Slater DN, et al. Uveal and cutaneous involvement in paraneoplastic melanocytic proliferation. Arch Ophthalmol. 2003;121(11):1637–40.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Shah, V.S. (2016). Paraneoplastic Retinopathy. In: Medina, C., Townsend, J., Singh, A. (eds) Manual of Retinal Diseases. Springer, Cham. https://doi.org/10.1007/978-3-319-20460-4_28
Download citation
DOI: https://doi.org/10.1007/978-3-319-20460-4_28
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-20459-8
Online ISBN: 978-3-319-20460-4
eBook Packages: MedicineMedicine (R0)