Abstract
The metabolism of sulfur has been widely studied with major progress in plant model systems. In plants and humans alike, activation occurs in canonical steps starting from the highly inert oxy-anion sulfate by the action of the enzymes ATP sulfurylase and APS kinase, resulting in the production of the atypical nucleotides adenosine-5′-phosphosulfate (APS) and PAPS (3′-phospho-APS). This review compares novel insights into structure, mechanism and regulation of plant ATP sulfurylases and APS kinases with findings from human sulfation pathways to highlight the benefit of “looking over the fence” and engaging in truly interdisciplinary research.
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Acknowledgement
W. Arlt is cordially acknowledged for her generous support and critical review of the manuscript. JWM also wants to acknowledge David Lodge from the University of Birmingham for various insights. JWM is a recipient of the Marie Curie IEF award 625451 SUPA-HD: Sulfation pathways in Health and Disease. Finally, we thank the Biochemical Society, UK, for a travel award (to JWM) to attend the 9th International Workshop on Sulfur Metabolism in Plants, Freiburg, Germany.
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Mueller, J.W., O’Neill, N., Shafqat, N. (2015). Small World: A Plant Perspective on Human Sulfate Activation. In: De Kok, L., Hawkesford, M., Rennenberg, H., Saito, K., Schnug, E. (eds) Molecular Physiology and Ecophysiology of Sulfur. Proceedings of the International Plant Sulfur Workshop. Springer, Cham. https://doi.org/10.1007/978-3-319-20137-5_6
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DOI: https://doi.org/10.1007/978-3-319-20137-5_6
Publisher Name: Springer, Cham
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