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Chromosomal Translocations in B Cell Lymphomas

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Chromosomal Translocations and Genome Rearrangements in Cancer

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Abstract

B cell lymphomas represent a diverse group of biologically and clinically distinct neoplasms, encompassing over 40 subtypes that derive from the malignant transformation of mature B cells, most commonly at the germinal centre (GC) stage of differentiation. Analogous to most cancer types, these tumours are caused by alterations of oncogenes and tumour suppressor genes, some of which have specific roles in GC development. This chapter will focus on the mechanisms and consequences of chromosomal translocations and other genetic lesions involved in the pathogenesis of the most common types of mature B cell lymphomas, including Mantle Cell Lymphoma, Follicular Lymphoma, Diffuse Large B Cell Lymphoma, and Burkitt Lymphoma.

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Authors and Affiliations

  1. Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, 10032, USA

    Marco Fangazio, Laura Pasqualucci & Riccardo Dalla-Favera

  2. Department of Pathology and Cell Biology, Columbia University, New York, NY, 10032, USA

    Laura Pasqualucci & Riccardo Dalla-Favera

  3. Department of Genetics and Development, Columbia University, New York, NY, 10032, USA

    Riccardo Dalla-Favera

  4. Department of Microbiology and Immunology, Columbia University, New York, NY, 10032, USA

    Riccardo Dalla-Favera

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  1. Marco Fangazio
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  2. Laura Pasqualucci
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  3. Riccardo Dalla-Favera
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Correspondence to Riccardo Dalla-Favera .

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Editors and Affiliations

  1. Dept. of Medicine, Section of Hematol./Oncol., University of Chicago, CHICAGO, Illinois, USA

    Janet D. Rowley

  2. Section of Hematology/Oncology, Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, USA

    Michelle M. Le Beau

  3. Weatherall Inst. of Molecular Medicine MRC Molecular Haematology Unit, University of Oxford, Oxford, United Kingdom

    Terence H. Rabbitts

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Fangazio, M., Pasqualucci, L., Dalla-Favera, R. (2015). Chromosomal Translocations in B Cell Lymphomas. In: Rowley, J., Le Beau, M., Rabbitts, T. (eds) Chromosomal Translocations and Genome Rearrangements in Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-19983-2_9

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