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Molecular Genetics Methods in Discovery of Chromosome Structure

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Chromosomal Translocations and Genome Rearrangements in Cancer

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Abstract

Somatically acquired tumour genome alterations underlie many of the changes in gene expression that promote tumour formation. These changes, ranging from single nucleotide changes to those involving parts of chromosomes or whole chromosomes, likely reflect the many different solutions taken by individual tumours to escape normal growth regulatory mechanisms. A variety of molecular and cytogenetic techniques, differing in resolution and capabilities for high throughput or single cell analysis, for example, have been used to investigate the altered state of tumour genomes. Some of these methods have become the mainstay of clinical cancer diagnosis and patient management.

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Author information

Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY, 10010, USA

    Donna G. Albertson

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  1. Donna G. Albertson
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Correspondence to Donna G. Albertson .

Editor information

Editors and Affiliations

  1. Dept. of Medicine, Section of Hematol./Oncol., University of Chicago, CHICAGO, Illinois, USA

    Janet D. Rowley

  2. Section of Hematology/Oncology, Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, USA

    Michelle M. Le Beau

  3. Weatherall Inst. of Molecular Medicine MRC Molecular Haematology Unit, University of Oxford, Oxford, United Kingdom

    Terence H. Rabbitts

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© 2015 Springer International Publishing Switzerland

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Albertson, D.G. (2015). Molecular Genetics Methods in Discovery of Chromosome Structure. In: Rowley, J., Le Beau, M., Rabbitts, T. (eds) Chromosomal Translocations and Genome Rearrangements in Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-19983-2_2

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