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Chromosomal Translocations in Lung Cancer

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Chromosomal Translocations and Genome Rearrangements in Cancer

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Abstract

Discovery of the EML4-ALK fusion-type oncogene had triggered extensive search for tyrosine kinase fusions in lung cancer (and other cancer types), resulting in the identification of various ALK-, ROS1-, RET-, FGFR1/2/3- and other kinase gene-fusions. Marked therapeutic efficacy of ALK inhibitors was swiftly confirmed in patients with ALK-rearranged tumours, and some of the compounds are already brought to the clinics. Likewise, specific inhibitors for each fusion kinase are currently under clinical investigation. Lung cancer is thus one of the tumour types that identification of fusion genes has most contributed to improve directly the treatment strategies for.

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Authors and Affiliations

  1. Department of Cellular Signaling, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyoku, Tokyo, 113-0033, Japan

    Hiroyuki Mano M.D., Ph.D.

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  1. Hiroyuki Mano M.D., Ph.D.
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Correspondence to Hiroyuki Mano M.D., Ph.D. .

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Editors and Affiliations

  1. Dept. of Medicine, Section of Hematol./Oncol., University of Chicago, CHICAGO, Illinois, USA

    Janet D. Rowley

  2. Section of Hematology/Oncology, Comprehensive Cancer Center, University of Chicago, Chicago, Illinois, USA

    Michelle M. Le Beau

  3. Weatherall Inst. of Molecular Medicine MRC Molecular Haematology Unit, University of Oxford, Oxford, United Kingdom

    Terence H. Rabbitts

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Mano, H. (2015). Chromosomal Translocations in Lung Cancer. In: Rowley, J., Le Beau, M., Rabbitts, T. (eds) Chromosomal Translocations and Genome Rearrangements in Cancer. Springer, Cham. https://doi.org/10.1007/978-3-319-19983-2_18

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