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Oxidative Stress and Obesity

  • Chapter
Obesity

Abstract

In the last few years, several studies have shown a strong association among obesity, altered redox state and inflammation; these studies have also shown that such alterations may be the link between obesity and obesity-related diseases (including Type 2 diabetes, cardiovascular disease, non-alcoholic fatty liver disease and cancer). Obese subjects usually show high levels of reactive oxygen or nitrogen species, impaired antioxidant defences and increased levels of inflammatory adipokines. Oxidative stress is certainly a result of excessive fat accumulation, but it has also been shown that oxidative stress, per se, leads to weight gain; therefore, it is not easy to establish the correct cause-effect relationship between obesity and oxidative stress.

This chapter analyses the main aspects linking oxidative stress to obesity, describing human studies in support of the association between alterations of redox homeostasis and obesity, the molecular mechanisms underlying these modifications and potential non-pharmacological strategies (including weight loss, physical activity, diet, dietary supplementation and microbiota modulation) aimed at reducing oxidative stress in obese individuals.

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Authors and Affiliations

  1. Department of Experimental Medicine and Surgery, University of Rome Tor Vergata, Via Montpellier 1, Rome, 00133, Italy

    Isabella Savini, Valeria Gasperi & Maria Valeria Catani

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  2. Valeria Gasperi
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  1. School of Science and Technology, Nottingham Trent University, Nottingham, United Kingdom

    Shamim I. Ahmad

  2. Al Mouwasat Hospital, Jubail, Saudi Arabia

    Syed Khalid Imam

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Savini, I., Gasperi, V., Catani, M.V. (2016). Oxidative Stress and Obesity. In: Ahmad, S., Imam, S. (eds) Obesity. Springer, Cham. https://doi.org/10.1007/978-3-319-19821-7_6

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