Skip to main content

Abstract

This chapter focuses on hospital-acquired pneumonias (HAP) which are the second most common nosocomial infections after urinary tract infections, but account for the majority of deaths and costs due to hospital-acquired infections. Highlights of the chapter include the changing epidemiology, pathogenesis, and treatment of HAP, including ventilator-associated pneumonia (VAP), and ventilator-associated tracheobronchitis (VAT). Our primary focus is on the common bacterial pathogens causing HAP and VAP in immunocompetent adults and multidrug-resistant pathogens that have emerged over the past decade. We emphasize evidence-based clinical management and current emerging prevention strategies aimed at improving patient outcomes, decreasing health expenditures and reducing chronic impairments following critical illness.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Tablan OC, Anderson LJ, Besser R, Bridges C, Hajjeh R. Guidelines for preventing health-care—associated pneumonia, 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR Recomm Rep. 2004;53:1–36.

    PubMed  Google Scholar 

  2. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005;171:388–416.

    Google Scholar 

  3. Kollef MH, Morrow LE, Baughman RP, Craven DE, McGowan JE Jr, Micek ST, et al. Health care-associated pneumonia (HCAP): a critical appraisal to improve identification, management, and outcomes—proceedings of the HCAP Summit. Clin Infect Dis. 2008;46 Suppl 4:S296–334.

    Google Scholar 

  4. Kollef MH. Prevention of hospital-associated pneumonia and ventilator-associated pneumonia. Crit Care Med. 2004;32:1396–405.

    Article  PubMed  Google Scholar 

  5. Richards MJ, Edwards JR, Culver DH, Gaynes RP. Nosocomial infections in medical intensive care units in the United States. National Nosocomial Infections Surveillance System. Crit Care Med. 1999;27:887–92.

    Article  CAS  PubMed  Google Scholar 

  6. Chastre J, Fagon JY. Ventilator-associated pneumonia. Am J Respir Crit Care Med. 2002;165:867–903.

    Article  PubMed  Google Scholar 

  7. Dudeck MA, Horan TC, Peterson KD, Allen-Bridson K, Morrell G, Pollock DA, et al. National Healthcare Safety Network (NHSN) Report, data summary for 2010, device-associated module. Am J Infect Control. 2011;39:798–816.

    Article  PubMed  Google Scholar 

  8. Rello J, Ollendorf DA, Oster G, Vera-Llonch M, Bellm L, Redman R, et al. Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest. 2002;122:2115–21.

    Article  PubMed  Google Scholar 

  9. Heyland DK, Cook DJ, Griffith L, Keenan SP, Brun-Buisson C. The attributable morbidity and mortality of ventilator-associated pneumonia in the critically ill patient. The Canadian Critical Trials Group. Am J Respir Crit Care Med. 1999;159:1249–56.

    Article  CAS  PubMed  Google Scholar 

  10. Cook DJ, Walter SD, Cook RJ, Griffith LE, Guyatt GH, Leasa D, et al. Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med. 1998;129:433–40.

    Article  CAS  PubMed  Google Scholar 

  11. Warren DK, Shukla SJ, Olsen MA, Kollef MH, Hollenbeak CS, Cox MJ, et al. Outcome and attributable cost of ventilator-associated pneumonia among intensive care unit patients in a suburban medical center. Crit Care Med. 2003;31:1312–7.

    Article  PubMed  Google Scholar 

  12. Bergmans DC, Bonten MJ, Gaillard CA, Paling JC, van der Geest S, van Tiel FH, et al. Prevention of ventilator-associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled study. Am J Respir Crit Care Med. 2001;164:382–8.

    Article  CAS  PubMed  Google Scholar 

  13. Niederman MS, Craven DE. Devising strategies for preventing nosocomial pneumonia—should we ignore the stomach? Clin Infect Dis. 1997;24:320–3.

    Article  CAS  PubMed  Google Scholar 

  14. Bonten MJ, Gaillard CA. Ventilator-associated pneumonia: do the bacteria come from the stomach? Neth J Med. 1995;46:1–3.

    Article  CAS  PubMed  Google Scholar 

  15. Prod’hom G, Leuenberger P, Koerfer J, Blum A, Chiolero R, Schaller MD, et al. Nosocomial pneumonia in mechanically ventilated patients receiving antacid, ranitidine, or sucralfate as prophylaxis for stress ulcer. A randomized controlled trial. Ann Intern Med. 1994;120:653–62.

    Article  PubMed  Google Scholar 

  16. Craven DE, Lichtenberg DA, Goularte TA, Make BJ, McCabe WR. Contaminated medication nebulizers in mechanical ventilator circuits. Source of bacterial aerosols. Am J Med. 1984;77:834–8.

    Article  CAS  PubMed  Google Scholar 

  17. Craven DE, Steger KA. Nosocomial pneumonia in mechanically ventilated adult patients: epidemiology and prevention in 1996. Semin Respir Infect. 1996;11:32–53.

    CAS  PubMed  Google Scholar 

  18. Inglis TJ, Lim EW, Lee GS, Cheong KF, Ng KS. Endogenous source of bacteria in tracheal tube and proximal ventilator breathing system in intensive care patients. Br J Anaesth. 1998;80:41–5.

    Article  CAS  PubMed  Google Scholar 

  19. Nseir S, Favory R, Jozefowicz E, Decamps F, Dewavrin F, Brunin G, et al. Antimicrobial treatment for ventilator-associated tracheobronchitis: a randomized, controlled, multicenter study. Crit Care. 2008;12:R62.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Craven DE, Chroneou A, Zias N, Hjalmarson KI. Ventilator-associated tracheobronchitis: the impact of targeted antibiotic therapy on patient outcomes. Chest. 2009;135:521–8.

    Article  PubMed  Google Scholar 

  21. Determann RM, Millo JL, Gibot S, Korevaar JC, Vroom MB, van der Poll T, et al. Serial changes in soluble triggering receptor expressed on myeloid cells in the lung during development of ventilator-associated pneumonia. Intensive Care Med. 2005;31:1495–500.

    Article  PubMed  Google Scholar 

  22. Gibot S, Cravoisy A, Levy B, Bene MC, Faure G, Bollaert PE. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med. 2004;350:451–8.

    Article  CAS  PubMed  Google Scholar 

  23. National Nosocomial Infections Surveillance (NNIS) system report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control. 2004;32:470–85.

    Google Scholar 

  24. Torres A, Aznar R, Gatell JM, Jimenez P, Gonzalez J, Ferrer A, et al. Incidence, risk, and prognosis factors of nosocomial pneumonia in mechanically ventilated patients. Am Rev Respir Dis. 1990;142:523–8.

    Article  CAS  PubMed  Google Scholar 

  25. Rello J, Lorente C, Diaz E, Bodi M, Boque C, Sandiumenge A, et al. Incidence, etiology, and outcome of nosocomial pneumonia in ICU patients requiring percutaneous tracheotomy for mechanical ventilation. Chest. 2003;124:2239–43.

    Article  PubMed  Google Scholar 

  26. Craven DE, Grgurich P, Steger Craven K, Balaguera H. Hospital-acquired and ventilator-associated pneumonia (Chapter 32). In: Jarvis WR, editor. Bennett and Brashman’s hospital infections. Philadelphia: Kluwer; 2013. p. 485–500. ISBN-13:978-1451175929; ISBN-10:1451175922.

    Google Scholar 

  27. Trouillet JL, Chastre J, Vuagnat A, Joly-Guillou ML, Combaux D, Dombret MC, et al. Ventilator-associated pneumonia caused by potentially drug-resistant bacteria. Am J Respir Crit Care Med. 1998;157:531–9.

    Article  CAS  PubMed  Google Scholar 

  28. Kollef MH, Shorr A, Tabak YP, Gupta V, Liu LZ, Johannes RS. Epidemiology and outcomes of health-care-associated pneumonia: results from a large US database of culture-positive pneumonia. Chest. 2005;128:3854–62.

    Article  PubMed  Google Scholar 

  29. Craven DE. What is healthcare-associated pneumonia, and how should it be treated? Curr Opin Infect Dis. 2006;19:153–60.

    PubMed  Google Scholar 

  30. El-Solh AA, Aquilina AT, Dhillon RS, Ramadan F, Nowak P, Davies J. Impact of invasive strategy on management of antimicrobial treatment failure in institutionalized older people with severe pneumonia. Am J Respir Crit Care Med. 2002;166:1038–43.

    Article  PubMed  Google Scholar 

  31. Pugin J, Auckenthaler R, Mili N, Janssens JP, Lew PD, Suter PM. Diagnosis of ventilator-associated pneumonia by bacteriologic analysis of bronchoscopic and nonbronchoscopic “blind” bronchoalveolar lavage fluid. Am Rev Respir Dis. 1991;143:1121–9.

    Article  CAS  PubMed  Google Scholar 

  32. Fridkin SK. Increasing prevalence of antimicrobial resistance in intensive care units. Crit Care Med. 2001;29:N64–8.

    Article  CAS  PubMed  Google Scholar 

  33. Mylotte JM. Nursing home-acquired pneumonia. Clin Infect Dis. 2002;35:1205–11.

    Article  PubMed  Google Scholar 

  34. Fartoukh M, Maitre B, Honore S, Cerf C, Zahar JR, Brun-Buisson C. Diagnosing pneumonia during mechanical ventilation: the clinical pulmonary infection score revisited. Am J Respir Crit Care Med. 2003;168:173–9.

    Article  PubMed  Google Scholar 

  35. Zilberberg MD, Shorr AF. Ventilator-associated pneumonia: the clinical pulmonary infection score as a surrogate for diagnostics and outcome. Clin Infect Dis. 2010;51 Suppl 1:S131–5.

    Google Scholar 

  36. Espy MJ, Uhl JR, Sloan LM, Buckwalter SP, Jones MF, Vetter EA, et al. Real-time PCR in clinical microbiology: applications for routine laboratory testing. Clin Microbiol Rev. 2006;19:165–256.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Berton DC, Kalil AC, Teixeira PJ. Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia. Cochrane Database Syst Rev. 2012;1:CD006482.

    Google Scholar 

  38. Kollef MH, Ward S. The influence of mini-BAL cultures on patient outcomes: implications for the antibiotic management of ventilator-associated pneumonia. Chest. 1998;113:412–20.

    Article  CAS  PubMed  Google Scholar 

  39. Clec’h C, Timsit JF, De Lassence A, Azoulay E, Alberti C, Garrouste-Orgeas M, et al. Efficacy of adequate early antibiotic therapy in ventilator-associated pneumonia: influence of disease severity. Intensive Care Med. 2004;30:1327–33.

    Article  PubMed  Google Scholar 

  40. Iregui M, Ward S, Sherman G, Fraser VJ, Kollef MH. Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest. 2002;122:262–8.

    Article  PubMed  Google Scholar 

  41. Dupont H, Mentec H, Sollet JP, Bleichner G. Impact of appropriateness of initial antibiotic therapy on the outcome of ventilator-associated pneumonia. Intensive Care Med. 2001;27:355–62.

    Article  CAS  PubMed  Google Scholar 

  42. Singh N, Rogers P, Atwood CW, Wagener MM, Yu VL. Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription. Am J Respir Crit Care Med. 2000;162:505–11.

    Article  CAS  PubMed  Google Scholar 

  43. Pugh R, Grant C, Cooke RPD, Dempsey G. Short-course versus prolonged-course antibiotic therapy for hospital acquired pneumonia in critically ill adults (Review). Cochrane Database Syst Rev. 2015;(8). Art. No.: CD007577.

    Google Scholar 

  44. Moise PA, Forrest A, Bhavnani SM, Birmingham MC, Schentag JJ. Area under the inhibitory curve and a pneumonia scoring system for predicting outcomes of vancomycin therapy for respiratory infections by Staphylococcus aureus. Am J Health Syst Pharm. 2000;57 Suppl 2:S4–9.

    Google Scholar 

  45. Fagon J, Patrick H, Haas DW, Torres A, Gibert C, Cheadle WG, et al. Treatment of gram-positive nosocomial pneumonia. Prospective randomized comparison of quinupristin/dalfopristin versus vancomycin. Nosocomial Pneumonia Group. Am J Respir Crit Care Med. 2000;161:753–62.

    Article  CAS  PubMed  Google Scholar 

  46. Malangoni MA, Crafton R, Mocek FC. Pneumonia in the surgical intensive care unit: factors determining successful outcome. Am J Surg. 1994;167:250–5.

    Article  CAS  PubMed  Google Scholar 

  47. Rybak M, Lomaestro B, Rotschafer JC, Moellering Jr R, Craig W, Billeter M, et al. Therapeutic monitoring of vancomycin in adult patients: a consensus review of the American Society of Health-System Pharmacists, the Infectious Diseases Society of America, and the Society of Infectious Diseases Pharmacists. Am J Health Syst Pharm. 2009;66:82–98.

    Article  CAS  PubMed  Google Scholar 

  48. Rybak MJ, Lomaestro BM, Rotschafer JC, Moellering RC, Craig WA, Billeter M, et al. Vancomycin therapeutic guidelines: a summary of consensus recommendations from the infectious diseases Society of America, the American Society of Health-System Pharmacists, and the Society of Infectious Diseases Pharmacists. Clin Infect Dis. 2009;49:325–7.

    Article  PubMed  Google Scholar 

  49. Wysocki M, Thomas F, Wolff MA, Pean Y, Ravaud Y, Herman B. Comparison of continuous with discontinuous intravenous infusion of vancomycin in severe MRSA infections. J Antimicrob Chemother. 1995;35:352–4.

    Article  CAS  PubMed  Google Scholar 

  50. Sivagnanam S, Deleu D. Red man syndrome. Crit Care. 2003;7:119–20.

    Article  PubMed  Google Scholar 

  51. Wunderink RG, Rello J, Cammarata SK, Croos-Dabrera RV, Kollef MH. Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia. Chest. 2003;124:1789–97.

    Article  CAS  PubMed  Google Scholar 

  52. Rubinstein E, Cammarata S, Oliphant T, Wunderink R. Linezolid (PNU-100766) versus vancomycin in the treatment of hospitalized patients with nosocomial pneumonia: a randomized, double-blind, multicenter study. Clin Infect Dis. 2001;32:402–12.

    Article  CAS  PubMed  Google Scholar 

  53. Wunderink RG, Niederman MS, Kollef MH, Shorr AF, Kunkel MJ, Baruch A, et al. Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study. Clin Infect Dis. 2012;54:621–9.

    Article  CAS  PubMed  Google Scholar 

  54. Torres A. Antibiotic treatment against methicillin-resistant Staphylococcus aureus hospital- and ventilator-acquired pneumonia: a step forward but the battle continues. Clin Infect Dis. 2012;54:630–2.

    Article  PubMed  Google Scholar 

  55. Hamer DH. Treatment of nosocomial pneumonia and tracheobronchitis caused by multidrug-resistant Pseudomonas aeruginosa with aerosolized colistin. Am J Respir Crit Care Med. 2000;162:328–30.

    Article  CAS  PubMed  Google Scholar 

  56. Conte Jr JE, Golden JA, Kipps J, Zurlinden E. Intrapulmonary pharmacokinetics of linezolid. Antimicrob Agents Chemother. 2002;46:1475–80.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Goetz MB, Sayers J. Nephrotoxicity of vancomycin and aminoglycoside therapy separately and in combination. J Antimicrob Chemother. 1993;32(2):325–34.

    Article  CAS  PubMed  Google Scholar 

  58. Elting LS, Rubenstein EB, Kurtin D, Rolston KV, Fangtang J, Martin CG, et al. Mississippi mud in the 1990s: risks and outcomes of vancomycin-associated toxicity in general oncology practice. Cancer. 1998;83:2597–607.

    Article  CAS  PubMed  Google Scholar 

  59. Silverman JA, Mortin LI, Vanpraagh AD, Li T, Alder J. Inhibition of daptomycin by pulmonary surfactant: in vitro modeling and clinical impact. J Infect Dis. 2005;191:2149–52.

    Article  CAS  PubMed  Google Scholar 

  60. http://www.fda.gov/drugs/drugsafety/ucm224370.htm.

  61. Maclayton DO, Hall 2nd RG. Pharmacologic treatment options for nosocomial pneumonia involving methicillin-resistant Staphylococcus aureus. Ann Pharmacother. 2007;41:235–44.

    Article  CAS  PubMed  Google Scholar 

  62. Drew RH. Emerging options for treatment of invasive, multidrug-resistant Staphylococcus aureus infections. Pharmacotherapy. 2007;27:227–49.

    Article  CAS  PubMed  Google Scholar 

  63. Bush K, Heep M, Macielag MJ, Noel GJ. Anti-MRSA beta-lactams in development, with a focus on ceftobiprole: the first anti-MRSA beta-lactam to demonstrate clinical efficacy. Expert Opin Investig Drugs. 2007;16:419–29.

    Article  CAS  PubMed  Google Scholar 

  64. Salem AH, Zhanel GG, Ibrahim SA, Noreddin AM. Monte Carlo simulation analysis of ceftobiprole, dalbavancin, daptomycin, tigecycline, linezolid and vancomycin pharmacodynamics against intensive care unit-isolated methicillin-resistant Staphylococcus aureus. Clin Exp Pharmacol Physiol. 2014;41:437–43.

    Article  CAS  PubMed  Google Scholar 

  65. Fink MP, Snydman DR, Niederman MS, Leeper Jr KV, Johnson RH, Heard SO, et al. Treatment of severe pneumonia in hospitalized patients: results of a multicenter, randomized, double-blind trial comparing intravenous ciprofloxacin with imipenem-cilastatin. The Severe Pneumonia Study Group. Antimicrob Agents Chemother. 1994;38:547–57.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Cometta A, Baumgartner JD, Lew D, Zimmerli W, Pittet D, Chopart P, et al. Prospective randomized comparison of imipenem monotherapy with imipenem plus netilmicin for treatment of severe infections in nonneutropenic patients. Antimicrob Agents Chemother. 1994;38:1309–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  67. Traugott KA, Echevarria K, Maxwell P, Green K, Lewis 2nd JS. Monotherapy or combination therapy? The Pseudomonas aeruginosa conundrum. Pharmacotherapy. 2011;31:598–608.

    Article  CAS  PubMed  Google Scholar 

  68. Hu Y, Li L, Li W, Xu H, He P, Yan X, et al. Combination antibiotic therapy versus monotherapy for Pseudomonas aeruginosa bacteraemia: a meta-analysis of retrospective and prospective studies. Int J Antimicrob Agents. 2013;42:492–6.

    Article  CAS  PubMed  Google Scholar 

  69. Garnacho-Montero J, Sa-Borges M, Sole-Violan J, Barcenilla F, Escoresca-Ortega A, Ochoa M, et al. Optimal management therapy for Pseudomonas aeruginosa ventilator-associated pneumonia: an observational, multicenter study comparing monotherapy with combination antibiotic therapy. Crit Care Med. 2007;35:1888–95.

    Article  CAS  PubMed  Google Scholar 

  70. Heyland DK, Dodek P, Muscedere J, Day A, Cook D. Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia. Crit Care Med. 2008;36:737–44.

    Article  PubMed  Google Scholar 

  71. Planquette B, Timsit JF, Misset BY, Schwebel C, Azoulay E, Adrie C, et al. Pseudomonas aeruginosa ventilator-associated pneumonia. predictive factors of treatment failure. Am J Respir Crit Care Med. 2013;188:69–76.

    Article  PubMed  Google Scholar 

  72. Wood GC, Hanes SD, Croce MA, Fabian TC, Boucher BA. Comparison of ampicillin-sulbactam and imipenem-cilastatin for the treatment of acinetobacter ventilator-associated pneumonia. Clin Infect Dis. 2002;34:1425–30.

    Article  CAS  PubMed  Google Scholar 

  73. Chu ML, Rowe D, Nicholls AC, Pope FM, Prockop DJ. Presence of translatable mRNA for pro alpha 2(I) chains in fibroblasts from a patient with osteogenesis imperfecta whose type I collagen does not contain alpha 2(I) chains. Coll Relat Res. 1984;4:389–94.

    Article  CAS  PubMed  Google Scholar 

  74. Garnacho-Montero J, Ortiz-Leyba C, Jimenez-Jimenez FJ, Barrero-Almodovar AE, Garcia-Garmendia JL, Bernabeu-Wittel IM, et al. Treatment of multidrug-resistant Acinetobacter baumannii ventilator-associated pneumonia (VAP) with intravenous colistin: a comparison with imipenem-susceptible VAP. Clin Infect Dis. 2003;36:1111–8.

    Article  CAS  PubMed  Google Scholar 

  75. Aydemir H, Akduman D, Piskin N, Comert F, Horuz E, Terzi A, et al. Colistin vs. the combination of colistin and rifampicin for the treatment of carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumonia. Epidemiol Infect. 2013;141:1214–22.

    Article  CAS  PubMed  Google Scholar 

  76. Paterson DL, Ko WC, Von Gottberg A, Casellas JM, Mulazimoglu L, Klugman KP, et al. Outcome of cephalosporin treatment for serious infections due to apparently susceptible organisms producing extended-spectrum beta-lactamases: implications for the clinical microbiology laboratory. J Clin Microbiol. 2001;39:2206–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Chow JW, Fine MJ, Shlaes DM, Quinn JP, Hooper DC, Johnson MP, et al. Enterobacter bacteremia: clinical features and emergence of antibiotic resistance during therapy. Ann Intern Med. 1991;115:585–90.

    Article  CAS  PubMed  Google Scholar 

  78. Queenan AM, Foleno B, Gownley C, Wira E, Bush K. Effects of inoculum and beta-lactamase activity in AmpC- and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae clinical isolates tested by using NCCLS ESBL methodology. J Clin Microbiol. 2004;42:269–75.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Paterson DL, Ko WC, Von Gottberg A, Mohapatra S, Casellas JM, Goossens H, et al. Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases. Clin Infect Dis. 2004;39:31–7.

    Article  CAS  PubMed  Google Scholar 

  80. Kollef MH, Hamilton CW, Montgomery AB. Aerosolized antibiotics: do they add to the treatment of pneumonia? Curr Opin Infect Dis. 2013;26:538–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Palmer LB et al. Crit Care Med. 2008;36:2008–13.

    Google Scholar 

  82. Palmer LB, Smaldone GC. Am J Respir Crit Care Med. 2014;189:1225–33.

    Google Scholar 

  83. www.cdc.gov/nhsm/psc_da-vae.html.

  84. Zack JE, Garrison T, Trovillion E, Clinkscale D, Coopersmith CM, Fraser VJ, et al. Effect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia. Crit Care Med. 2002;30:2407–12.

    Article  PubMed  Google Scholar 

  85. Babcock HM, Zack JE, Garrison T, Trovillion E, Kollef MH, Fraser VJ. Ventilator-associated pneumonia in a multi-hospital system: differences in microbiology by location. Infect Control Hosp Epidemiol. 2003;24:853–8.

    Article  PubMed  Google Scholar 

  86. Crnich CJ, Safdar N, Maki DG. The role of the intensive care unit environment in the pathogenesis and prevention of ventilator-associated pneumonia. Respir Care. 2005;50:813–36.

    PubMed  Google Scholar 

  87. Dang D, Johantgen ME, Pronovost PJ, Jenckes MW, Bass EB. Postoperative complications: does intensive care unit staff nursing make a difference? Heart Lung. 2002;31:219–28.

    Article  PubMed  Google Scholar 

  88. Safdar N, Crnich CJ, Maki DG. The pathogenesis of ventilator-associated pneumonia: its relevance to developing effective strategies for prevention. Respir Care. 2005;50:725–39.

    PubMed  Google Scholar 

  89. Bonten MJ, Weinstein RA. Infection control in intensive care units and prevention of ventilator-associated pneumonia. Semin Respir Infect. 2000;15:327–35.

    Article  CAS  PubMed  Google Scholar 

  90. Eggimann P, Pittet D. Infection control in the ICU. Chest. 2001;120:2059–93.

    Article  CAS  PubMed  Google Scholar 

  91. Rosenthal VD, Guzman S, Crnich C. Impact of an infection control program on rates of ventilator-associated pneumonia in intensive care units in 2 Argentinean hospitals. Am J Infect Control. 2006;34:58–63.

    Article  PubMed  Google Scholar 

  92. Crnich CJ, Proctor RA. Ventilator-associated pneumonia: does surveillance have a role in its management? Crit Care Med. 2003;31:2411–2.

    Article  PubMed  Google Scholar 

  93. Eggimann P, Hugonnet S, Sax H, Touveneau S, Chevrolet JC, Pittet D. Ventilator-associated pneumonia: caveats for benchmarking. Intensive Care Med. 2003;29:2086–9.

    Article  PubMed  Google Scholar 

  94. Ibrahim EH, Ward S, Sherman G, Schaiff R, Fraser VJ, Kollef MH. Experience with a clinical guideline for the treatment of ventilator-associated pneumonia. Crit Care Med. 2001;29:1109–15.

    Article  CAS  PubMed  Google Scholar 

  95. L'Heriteau F, Alberti C, Cohen Y, Troche G, Moine P, Timsit JF. Nosocomial infection and multidrug-resistant bacteria surveillance in intensive care units: a survey in France. Infect Control Hosp Epidemiol. 2005;26:13–20.

    Article  PubMed  Google Scholar 

  96. Vandenbroucke-Grauls C, Schultsz C. Surveillance in infection control: are we making progress? Curr Opin Infect Dis. 2002;15:415–9.

    Article  PubMed  Google Scholar 

  97. Muto CA. Methicillin-resistant Staphylococcus aureus control: we didn’t start the fire, but it’s time to put it out. Infect Control Hosp Epidemiol. 2006;27:111–5.

    Article  PubMed  Google Scholar 

  98. de Lassence A, Hidri N, Timsit JF, Joly-Guillou ML, Thiery G, Boyer A, et al. Control and outcome of a large outbreak of colonization and infection with glycopeptide-intermediate Staphylococcus aureus in an intensive care unit. Clin Infect Dis. 2006;42:170–8.

    Article  PubMed  Google Scholar 

  99. Vos MC, Ott A, Verbrugh HA. Successful search-and-destroy policy for methicillin-resistant Staphylococcus aureus in The Netherlands. J Clin Microbiol. 2005;43:2034.

    Article  PubMed  PubMed Central  Google Scholar 

  100. Carling PC, Briggs JL, Perkins J, Highlander D. Improved cleaning of patient rooms using a new targeting method. Clin Infect Dis. 2006;42:385–8.

    Article  PubMed  Google Scholar 

  101. Madaras-Kelly KJ, Remington RE, Lewis PG, Stevens DL. Evaluation of an intervention designed to decrease the rate of nosocomial methicillin-resistant Staphylococcus aureus infection by encouraging decreased fluoroquinolone use. Infect Control Hosp Epidemiol. 2006;27:155–69.

    Article  PubMed  Google Scholar 

  102. Rahal JJ, Urban C, Segal-Maurer S. Nosocomial antibiotic resistance in multiple gram-negative species: experience at one hospital with squeezing the resistance balloon at multiple sites. Clin Infect Dis. 2002;34:499–503.

    Article  PubMed  Google Scholar 

  103. Warren DK, Hill HA, Merz LR, Kollef MH, Hayden MK, Fraser VJ, et al. Cycling empirical antimicrobial agents to prevent emergence of antimicrobial-resistant Gram-negative bacteria among intensive care unit patients. Crit Care Med. 2004;32:2450–6.

    Article  CAS  PubMed  Google Scholar 

  104. Isakow W, Kollef MH. Preventing ventilator-associated pneumonia: an evidence-based approach of modifiable risk factors. Semin Respir Crit Care Med. 2006;27:5–17.

    Article  PubMed  Google Scholar 

  105. Kollef MH, Vlasnik J, Sharpless L, Pasque C, Murphy D, Fraser V. Scheduled change of antibiotic classes: a strategy to decrease the incidence of ventilator-associated pneumonia. Am J Respir Crit Care Med. 1997;156:1040–8.

    Article  CAS  PubMed  Google Scholar 

  106. Parker CM, Heyland DK. Aspiration and the risk of ventilator-associated pneumonia. Nutr Clin Pract. 2004;19:597–609.

    Article  PubMed  Google Scholar 

  107. Pneumatikos J, Koulouras B, Frangides C, Goe D, Nakos G. Cisapride decreases gastric content aspiration in mechanically ventilated patients. Crit Care. 1999;3:39–43.

    Article  PubMed  PubMed Central  Google Scholar 

  108. Cook D, Mandell L. Endotracheal aspiration in the diagnosis of ventilator-associated pneumonia. Chest. 2000;117:195S–7.

    Article  CAS  PubMed  Google Scholar 

  109. Smith G, Ng A. Gastric reflux and pulmonary aspiration in anaesthesia. Minerva Anestesiol. 2003;69:402–6.

    CAS  PubMed  Google Scholar 

  110. Kallel H, Chelly H, Bahloul M, Ksibi H, Dammak H, Chaari A, et al. The effect of ventilator-associated pneumonia on the prognosis of head trauma patients. J Trauma. 2005;59:705–10.

    PubMed  Google Scholar 

  111. Drakulovic MB, Torres A, Bauer TT, Nicolas JM, Nogue S, Ferrer M. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial. Lancet. 1999;354:1851–8.

    Article  CAS  PubMed  Google Scholar 

  112. van Nieuwenhoven CA, Vandenbroucke-Grauls C, van Tiel FH, Joore HC, van Schijndel RJ, van der Tweel I, et al. Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study. Crit Care Med. 2006;34:396–402.

    Article  PubMed  Google Scholar 

  113. Leng YX, Song YH, Yao ZY, Zhu X. Effect of 45 degree angle semirecumbent position on ventilator-associated pneumonia in mechanical ventilated patients: a meta-analysis. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012;24:587–91.

    PubMed  Google Scholar 

  114. van Nieuwenhoven CA, Buskens E, Bergmans DC, van Tiel FH, Ramsay G, Bonten MJ. Oral decontamination is cost-saving in the prevention of ventilator-associated pneumonia in intensive care units. Crit Care Med. 2004;32:126–30.

    Article  PubMed  Google Scholar 

  115. Munro CL, Grap MJ. Oral health and care in the intensive care unit: state of the science. Am J Crit Care. 2004;13:25–33.

    PubMed  Google Scholar 

  116. Brennan MT, Bahrani-Mougeot F, Fox PC, Kennedy TP, Hopkins S, Boucher RC, et al. The role of oral microbial colonization in ventilator-associated pneumonia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:665–72.

    Article  PubMed  Google Scholar 

  117. Cutler CJ, Davis N. Improving oral care in patients receiving mechanical ventilation. Am J Crit Care. 2005;14:389–94.

    PubMed  Google Scholar 

  118. Mori H, Hirasawa H, Oda S, Shiga H, Matsuda K, Nakamura M. Oral care reduces incidence of ventilator-associated pneumonia in ICU populations. Intensive Care Med. 2006;32:230–6.

    Article  PubMed  Google Scholar 

  119. Koeman M, van der Ven AJ, Hak E, Joore HC, Kaasjager K, de Smet AG, et al. Oral decontamination with chlorhexidine reduces the incidence of ventilator-associated pneumonia. Am J Respir Crit Care Med. 2006;173:1348–55.

    Article  CAS  PubMed  Google Scholar 

  120. Chan EY, Ruest A, Meade MO, Cook DJ. Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis. BMJ. 2007;334:889.

    Article  PubMed  PubMed Central  Google Scholar 

  121. Chlebicki MP, Safdar N. Topical chlorhexidine for prevention of ventilator-associated pneumonia: a meta-analysis. Crit Care Med. 2007;35:595–602.

    Article  CAS  PubMed  Google Scholar 

  122. Liberati A, D’Amico R, Pifferi, Torri V, Brazzi L. Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Database Syst Rev. 2004;(1):CD000022.

    Google Scholar 

  123. Silvestri L, Petros AJ, Viviani M, Rommes JH, van Saene HK. Selective decontamination of the digestive tract and ventilator-associated pneumonia (part 1). Respir Care. 2006;51:67–9.

    PubMed  Google Scholar 

  124. Krueger WA, Unertl KE. Selective decontamination of the digestive tract. Curr Opin Crit Care. 2002;8:139–44.

    Article  PubMed  Google Scholar 

  125. Nathens AB, Marshall JC. Selective decontamination of the digestive tract in surgical patients: a systematic review of the evidence. Arch Surg. 1999;134:170–6.

    Article  CAS  PubMed  Google Scholar 

  126. Sirvent JM, Torres A, El-Ebiary M, Castro P, de Batlle J, Bonet A. Protective effect of intravenously administered cefuroxime against nosocomial pneumonia in patients with structural coma. Am J Respir Crit Care Med. 1997;155:1729–34.

    Article  CAS  PubMed  Google Scholar 

  127. Kallet RH, Quinn TE. The gastrointestinal tract and ventilator-associated pneumonia. Respir Care. 2005;50:910–21.

    PubMed  Google Scholar 

  128. Liberati A, D’Amico R, Pifferi S, Torri V, Brazzi L, Parmelli E. Antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving intensive care. Cochrane Database Syst Rev. 2009;(4):CD000022.

    Google Scholar 

  129. Silvestri L, van Saene HK. Selective decontamination of the digestive tract: an update of the evidence. HSR Proc Intensive Care Cardiovasc Anesth. 2013;4:21–9.

    Google Scholar 

  130. Kollef MH. Selective digestive decontamination should not be routinely employed. Chest. 2003;123:464S–8.

    Article  PubMed  Google Scholar 

  131. Hess DR, Kallstrom TJ, Mottram CD, Myers TR, Sorenson HM, Vines DL. Care of the ventilator circuit and its relation to ventilator-associated pneumonia. Respir Care. 2003;48:869–79.

    PubMed  Google Scholar 

  132. Dezfulian C, Shojania K, Collard HR, Kim HM, Matthay MA, Saint S. Subglottic secretion drainage for preventing ventilator-associated pneumonia: a meta-analysis. Am J Med. 2005;118:11–8.

    Article  PubMed  Google Scholar 

  133. Muscedere J, Rewa O, McKechnie K, Jiang X, Laporta D, Heyland DK. Subglottic secretion drainage for the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis. Crit Care Med. 2011;39:1985–91.

    Article  PubMed  Google Scholar 

  134. Kollef MH, Afessa B, Anzueto A, Veremakis C, Kerr KM, Margolis BD, et al. Silver-coated endotracheal tubes and incidence of ventilator-associated pneumonia: the NASCENT randomized trial. JAMA. 2008;300:805–13.

    Article  CAS  PubMed  Google Scholar 

  135. Burns KE, Adhikari NK, Meade MO. A meta-analysis of noninvasive weaning to facilitate liberation from mechanical ventilation. Can J Anaesth. 2006;53:305–15.

    Article  PubMed  Google Scholar 

  136. Esteban A, Frutos-Vivar F, Ferguson ND, Arabi Y, Apezteguia C, Gonzalez M, et al. Noninvasive positive-pressure ventilation for respiratory failure after extubation. N Engl J Med. 2004;350:2452–60.

    Article  CAS  PubMed  Google Scholar 

  137. De Jonghe B, Cook D, Sharshar T, Lefaucheur JP, Carlet J, Outin H. Acquired neuromuscular disorders in critically ill patients: a systematic review. Groupe de Reflexion et d’Etude sur les Neuromyopathies En Reanimation. Intensive Care Med. 1998;24:1242–50.

    Article  PubMed  Google Scholar 

  138. Torres A, Gatell JM, Aznar E, el-Ebiary M, Puig de la Bellacasa J, Gonzalez J, et al. Re-intubation increases the risk of nosocomial pneumonia in patients needing mechanical ventilation. Am J Respir Crit Care Med. 1995;152:137–41.

    Article  CAS  PubMed  Google Scholar 

  139. Dreyfuss D, Ricard JD. Acute lung injury and bacterial infection. Clin Chest Med. 2005;26:105–12.

    Article  PubMed  Google Scholar 

  140. Kress JP, Pohlman AS, O’Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med. 2000;342:1471–7.

    Article  CAS  PubMed  Google Scholar 

  141. Thorens JB, Kaelin RM, Jolliet P, Chevrolet JC. Influence of the quality of nursing on the duration of weaning from mechanical ventilation in patients with chronic obstructive pulmonary disease. Crit Care Med. 1995;23:1807–15.

    Article  CAS  PubMed  Google Scholar 

  142. Dries DJ, McGonigal MD, Malian MS, Bor BJ, Sullivan C. Protocol-driven ventilator weaning reduces use of mechanical ventilation, rate of early reintubation, and ventilator-associated pneumonia. J Trauma. 2004;56:943–51.

    Article  PubMed  Google Scholar 

  143. Schweickert WD, Gehlbach BK, Pohlman AS, Hall JB, Kress JP. Daily interruption of sedative infusions and complications of critical illness in mechanically ventilated patients. Crit Care Med. 2004;32:1272–6.

    Article  PubMed  Google Scholar 

  144. Schweickert WD, Pohlman MC, Pohlman AS, Nigos C, Pawlik AJ, Esbrook CL, et al. Early physical and occupational therapy in mechanically ventilated, critically ill patients: a randomised controlled trial. Lancet. 2009;373:1874–82.

    Article  PubMed  Google Scholar 

  145. Girard TD, Kress JP, Fuchs BD, Thomason JW, Schweickert WD, Pun BT, et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet. 2008;371:126–34.

    Article  PubMed  Google Scholar 

  146. Heyland DK, Drover JW, Dhaliwal R, Greenwood J. Optimizing the benefits and minimizing the risks of enteral nutrition in the critically ill: role of small bowel feeding. JPEN J Parenter Enteral Nutr. 2002;26:S51–5.

    Article  PubMed  Google Scholar 

  147. Bowman A, Greiner JE, Doerschug KC, Little SB, Bombei CL, Comried LM. Implementation of an evidence-based feeding protocol and aspiration risk reduction algorithm. Crit Care Nurs Q. 2005;28:324–33.

    Article  PubMed  Google Scholar 

  148. Morrow LE, Kollef MH, Casale TB. Probiotic prophylaxis of ventilator-associated pneumonia: a blinded, randomized, controlled trial. Am J Respir Crit Care Med. 2010;182:1058–64.

    Article  PubMed  PubMed Central  Google Scholar 

  149. Cook D, Guyatt G, Marshall J, Leasa D, Fuller H, Hall R, et al. A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian Critical Care Trials Group. N Engl J Med. 1998;338:791–7.

    Article  CAS  PubMed  Google Scholar 

  150. Eom CS, Jeon CY, Lim JW, Cho EG, Park SM, Lee KS. Use of acid-suppressive drugs and risk of pneumonia: a systematic review and meta-analysis. CMAJ. 2011;183:310–9.

    Article  PubMed  PubMed Central  Google Scholar 

  151. Pongprasobchai S, Kridkratoke S, Nopmaneejumruslers C. Proton pump inhibitors for the prevention of stress-related mucosal disease in critically-ill patients: a meta-analysis. J Med Assoc Thai. 2009;92:632–7.

    PubMed  Google Scholar 

  152. Linsky A, Gupta K, Lawler EV, Fonda JR, Hermos JA. Proton pump inhibitors and risk for recurrent Clostridium difficile infection. Arch Intern Med. 2010;170:772–8.

    Article  PubMed  Google Scholar 

  153. Maggio M, Corsonello A, Ceda GP, Cattabiani C, Lauretani F, Butto V, et al. Proton pump inhibitors and risk of 1-year mortality and rehospitalization in older patients discharged from acute care hospitals. JAMA Intern Med. 2013;173:518–23.

    Article  PubMed  Google Scholar 

  154. Jensen LS, Kissmeyer-Nielsen P, Wolff B, Qvist N. Randomised comparison of leucocyte-depleted versus buffy-coat-poor blood transfusion and complications after colorectal surgery. Lancet. 1996;348:841–5.

    Article  CAS  PubMed  Google Scholar 

  155. Nseir S, Ader F, Marquette CH. Nosocomial tracheobronchitis. Curr Opin Infect Dis. 2009;22:148–53.

    Article  PubMed  Google Scholar 

  156. Craven DE, Lei Y, Ruthazer R, Sarwar A, Hudcova J. Incidence and outcomes of ventilator-associated tracheobronchitis and pneumonia. Am J Med. 2013;126:542–9.

    Article  PubMed  Google Scholar 

  157. Unroe M, Kahn JM, Carson SS, Govert JA, Martinu T, Sathy SJ, et al. One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study. Ann Intern Med. 2010;153:167–75.

    Article  PubMed  PubMed Central  Google Scholar 

  158. Epstein AM. Revisiting readmissions—changing the incentives for shared accountability. N Engl J Med. 2009;360:1457–9.

    Article  CAS  PubMed  Google Scholar 

  159. Jencks SF, Williams MV, Coleman EA. Rehospitalizations among patients in the Medicare fee-for-service program. N Engl J Med. 2009;360:1418–28.

    Article  CAS  PubMed  Google Scholar 

  160. Bodenheimer T. Coordinating care—a perilous journey through the health care system. N Engl J Med. 2008;358:1064–71.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jana Hudcova MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Hudcova, J., Craven, K.A., Craven, D.E. (2016). Pneumonia. In: O'Donnell, J., Nácul, F. (eds) Surgical Intensive Care Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-19668-8_30

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-19668-8_30

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-19667-1

  • Online ISBN: 978-3-319-19668-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics