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PET/MRI: Physics, Instrumentation, and Systems

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Molecular and Multimodality Imaging in Cardiovascular Disease

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Abstract

Hybrid imaging with PET/MRI combines excellent soft tissue contrast and various functional imaging parameters provided by MR imaging with high sensitivity and quantification of radiotracer uptake provided by PET. While clinical evaluation now is under way, PET/MRI demands for new technologies and innovative methodological solutions, currently subject to interdisciplinary research. Attenuation correction (AC) of the patient tissues has to be MR based since CT attenuation information is missing. MR-based AC, however, is inherently associated with challenges: patient tissues are segmented into only few tissue classes, providing discrete attenuation coefficients, and the bone is substituted as soft tissue in MR-based AC. Additionally, hardware components such as the system’s patient table and radiofrequency (RF) coils for MR imaging need to be considered in AC to maintain quantification of PET imaging. This chapter provides an introduction into current PET/MRI system designs and into physical challenges and methodological solutions for attenuation and motion correction. Furthermore, specific challenges of cardiac PET/MR hybrid imaging are highlighted.

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References

  1. Delso G, Furst S, Jakoby B, et al. Performance measurements of the Siemens mMR integrated whole-body PET/MR scanner. J Nucl Med. 2011;52:1914–22.

    Article  PubMed  Google Scholar 

  2. Zaidi H, Ojha N, Morich M, et al. Design and performance evaluation of a whole-body Ingenuity TF PET-MRI system. Phys Med Biol. 2011;56:3091–106.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Quick HH. Integrated PET/MR. J Magn Reson Imaging. 2014;39:243–58.

    Article  PubMed  Google Scholar 

  4. Nensa F, Poeppel TD, Beiderwellen K, et al. Hybrid PET/MR imaging of the heart: feasibility and initial results. Radiology. 2013;268:366–73.

    Article  PubMed  Google Scholar 

  5. Rischpler C, Nekolla SG, Dregely I, Schwaiger M. Hybrid PET/MR imaging of the heart: potential, initial experiences, and future prospects. J Nucl Med. 2013;54:402–15.

    Article  CAS  PubMed  Google Scholar 

  6. Schlosser T, Nensa F, Mahabadi AA, Poeppel TD. Hybrid MRI/PET of the heart: a new complementary imaging technique for simultaneous acquisition of MRI and PET data. Heart. 2013;99:351–2.

    Article  PubMed  Google Scholar 

  7. Lee WW, Marinelli B, Van der Laan AM, et al. PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol. 2013;59:153–63.

    Article  CAS  Google Scholar 

  8. Martinez-Moller A, Souvatzoglou M, Delso G, et al. Tissue classification as a potential approach for attenuation correction in whole-body PET/MRI: evaluation with PET/CT data. J Nucl Med. 2009;50:520–6.

    Article  PubMed  Google Scholar 

  9. Samarin A, Burger C, Wollenweber SD, et al. PET/MR imaging of bone lesions – implications for PET quantification from imperfect attenuation correction. Eur J Nucl Med Mol Imaging. 2012;39:1154–60.

    Article  PubMed  Google Scholar 

  10. Pichler BJ, Judenhofer MS, Catana C, et al. Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI. J Nucl Med. 2006;47:639–47.

    PubMed  Google Scholar 

  11. Lecomte R. Novel detector technology for clinical PET. Eur J Nucl Med Mol Imaging. 2009;32:S69–85.

    Article  Google Scholar 

  12. Schaart DR, van Dam HT, Seifert S, et al. A novel, SiPM-array-based, monolithic scintillator detector for PET. Phys Med Biol. 2009;54:3501–12.

    Article  CAS  PubMed  Google Scholar 

  13. Levin C, Glover G, Deller T, et al. Prototype time-of-flight PET ring integrated with a 3T MRI system for simultaneous whole-body PET/MR imaging [abstract]. J Nucl Med. 2013;54 Suppl 2:148.

    Google Scholar 

  14. Carney JPJ, Townsend DW, Rappoport V, Bendriem B. Method for transforming CT images for attenuation correction in PET/CT imaging. Med Phys. 2006;33:976–83.

    Article  PubMed  Google Scholar 

  15. Delso G, Martinez-Möller A, Bundschuh RA, et al. Evaluation of the attenuation properties of MR equipment for its use in a whole-body PET/MR scanner. Phys Med Biol. 2010;55:4361–74.

    Article  CAS  PubMed  Google Scholar 

  16. Tellmann L, Quick HH, Bockisch A, Herzog H, Beyer T. The effect of MR surface coils on PET quantification in whole-body PET/MR. Med Phys. 2011;38:2795–805.

    Article  CAS  PubMed  Google Scholar 

  17. Paulus DH, Braun H, Aklan, Quick HH. Simultaneous PET/MR imaging: MR-based attenuation correction of local radiofrequency surface coils. Med Phys. 2012;39:4306–15.

    Google Scholar 

  18. Paulus DH, Tellmann L, Quick HH. Towards improved hardware component attenuation correction in PET/MR hybrid imaging. Phys Med Biol. 2013;58:8021–40.

    Article  CAS  PubMed  Google Scholar 

  19. Kartmann R, Paulus DH, Braun H, et al. Integrated PET/MR imaging: automatic attenuation correction of flexible RF coils. Med Phys. 2013;40(8):082301. doi:10.1118/1.4812685.

    Article  PubMed  Google Scholar 

  20. Tsoumpas C, Mackewn JE, Halsted P. Simultaneous PET-MR acquisition and MR-derived motion fields for correction of non-rigid motion in PET. Ann Nucl Med. 2010;24:745–50.

    Article  PubMed  Google Scholar 

  21. Tsoumpas C, Buerger C, King AP, et al. Fast generation of 4D PET-MR data from real dynamic MR acquisitions. Phys Med Biol. 2011;56:6597–613.

    Article  CAS  PubMed  Google Scholar 

  22. Catana C, Benner T, van der Kouwe A, et al. MRI-assisted PET motion correction for neurologic studies in an integrated MR/PET scanner. J Nucl Med. 2011;52:154–61.

    Article  PubMed Central  PubMed  Google Scholar 

  23. Brendle CB, Schmidt H, Fleischer S, Braeuning UH, Pfannenberg CA, Schwenzer NF. Simultaneously acquired MR/PET images compared with sequential MR/PET and PET/CT: alignment quality. Radiology. 2013;268:190–9.

    Article  PubMed  Google Scholar 

  24. Wuerslin C, Schmidt H, Martirosian P, et al. Respiratory motion correction in oncologic PET using T1-weighted MR imaging on a simultaneous whole-body PET/MR system. J Nucl Med. 2013;54:464–71.

    Article  CAS  Google Scholar 

  25. Grimm R, Fürst S, Dregely I, et al. Self-gated radial MRI for respiratory motion compensation on hybrid PET/MR systems. Med Image Comput Comput Assist Interv. 2013;16:17–24.

    PubMed  Google Scholar 

  26. Fieseler M, Kugel H, Gigengack F, et al. A dynamic thorax phantom for the assessment of cardiac and respiratory motion correction in PET/MRI: a preliminary evaluation. Nuc Instr Meth Phys Res A. 2013;702:59–63.

    Article  CAS  Google Scholar 

  27. Baumgartner CF, Kolbitsch C, Balfour DR, et al. High-resolution dynamic MR imaging of the thorax for respiratory motion correction of PET using groupwise manifold alignment. Med Image Anal. 2014;18:939–52.

    Article  PubMed  Google Scholar 

  28. Nensa F, Schlosser T. Cardiovascular hybrid imaging using PET/MRI. Rofo. 2014;186:1094–101.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Erwin L. Hahn Institute for MR Imaging, University of Duisburg-Essen, Essen, Germany

    Harald H. Quick PhD

  2. Department of High Field and Hybrid MR Imaging, University Hospital Essen, Essen, Germany

    Harald H. Quick PhD

Authors
  1. Harald H. Quick PhD
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Correspondence to Harald H. Quick PhD .

Editor information

Editors and Affiliations

  1. Johns Hopkins University, Radiology School of Medicine, Cardiovascular Nuclear Medicine, Baltimore, Maryland, USA

    Thomas H. Schindler

  2. Johns Hopkins University, School of Medicine, Cardiology, Baltimore, Maryland, USA

    Richard T. George

  3. Radiology and Epidemiology, Johns Hopkins University, School of Medicine, Cardiology, Baltimore, Maryland, USA

    Joao A.C. Lima

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© 2015 Springer International Publishing Switzerland

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Quick, H.H. (2015). PET/MRI: Physics, Instrumentation, and Systems. In: Schindler, T., George, R., Lima, J. (eds) Molecular and Multimodality Imaging in Cardiovascular Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-19611-4_1

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  • DOI: https://doi.org/10.1007/978-3-319-19611-4_1

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-19610-7

  • Online ISBN: 978-3-319-19611-4

  • eBook Packages: MedicineMedicine (R0)

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