Skip to main content
SpringerLink
Log in

Precision Medicine for Osteoarthritis

  • Chapter
Osteoarthritis

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Katsnelson A. Momentum grows to make “personalized” medicine more “precise”. Nat Med. 2013;19(3):249.

    Article  CAS  PubMed  Google Scholar 

  2. National Research Council (US) Committee on a Framework for Developing a New Taxonomy of Disease. Toward Precision Medicine: Building a Knowledge Network for Biomedical Research and a New Taxonomy of Disease [Internet]. Washington, DC: National Academies Press (US); 2011. http://www.ncbi.nlm.nih.gov/books/NBK91503/. Cited 6 Mar 2015.

  3. Topol EJ. The creative destruction of medicine: how the digital revolution will create better health care. New York: Basic Books; 2012. 322 p.

    Google Scholar 

  4. Karsdal MA, Christiansen C, Ladel C, Henriksen K, Kraus VB, Bay-Jensen AC. Osteoarthritis–a case for personalized health care? Osteoarthr Cartil OARS Osteoarthr Res Soc. 2014;22(1):7–16.

    Article  CAS  Google Scholar 

  5. Spear BB, Heath-Chiozzi M, Huff J. Clinical application of pharmacogenetics. Trends Mol Med. 2001;7(5):201–4.

    Article  CAS  PubMed  Google Scholar 

  6. Baumann C, Rat A-C, Mainard D, Cuny C, Guillemin F. Importance of patient satisfaction with care in predicting osteoarthritis-specific health-related quality of life one year after total joint arthroplasty. Qual Life Res Int J Qual Life Asp Treat Care Rehabil. 2011;20(10):1581–8.

    Article  Google Scholar 

  7. Becker R, Döring C, Denecke A, Brosz M. Expectation, satisfaction and clinical outcome of patients after total knee arthroplasty. Knee Surg Sports Traumatol Arthrosc Off J ESSKA. 2011;19(9):1433–41.

    Article  Google Scholar 

  8. Pao W, Hutchinson KE. Chipping away at the lung cancer genome. Nat Med. 2012;18(3):349–51.

    Article  CAS  PubMed  Google Scholar 

  9. Zhu C-Q, Pintilie M, John T, Strumpf D, Shepherd FA, Der SD, et al. Understanding prognostic gene expression signatures in lung cancer. Clin Lung Cancer. 2009;10(5):331–40.

    Article  CAS  PubMed  Google Scholar 

  10. Sawitzke AD. Personalized medicine for osteoarthritis: where are we now? Ther Adv Musculoskelet Dis. 2013;5(2):67–75.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  11. Reynard LN, Loughlin J. Genetics and epigenetics of osteoarthritis. Maturitas. 2012;71(3):200–4.

    Article  CAS  PubMed  Google Scholar 

  12. Bijlsma JWJ, Berenbaum F, Lafeber FPJG. Osteoarthritis: an update with relevance for clinical practice. Lancet. 2011;377(9783):2115–26.

    Article  PubMed  Google Scholar 

  13. Carroll GJ, Breidahl WH, Jazayeri J. Confirmation of two major polyarticular osteoarthritis (POA) phenotypes–differentiation on the basis of joint topography. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2009;17(7):891–5.

    Article  CAS  Google Scholar 

  14. Castañeda S, Roman-Blas JA, Largo R, Herrero-Beaumont G. Osteoarthritis: a progressive disease with changing phenotypes. Rheumatol Oxf Engl. 2014;53(1):1–3.

    Article  Google Scholar 

  15. Herrero-Beaumont G, Roman-Blas JA, Castañeda S, Jimenez SA. Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics. Semin Arthritis Rheum. 2009;39(2):71–80.

    Article  PubMed  Google Scholar 

  16. Karsdal MA, Bihlet A, Byrjalsen I, Alexandersen P, Ladel C, Michaels M, et al. OA phenotypes, rather than disease stage, drive structural progression – identification of structural progressors from 2 phase III randomized clinical studies with symptomatic knee OA. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2015;23(4):550–8.

    Article  CAS  Google Scholar 

  17. Knoop J, van der Leeden M, Thorstensson CA, Roorda LD, Lems WF, Knol DL, et al. Identification of phenotypes with different clinical outcomes in knee osteoarthritis: data from the Osteoarthritis Initiative. Arthritis Care Res. 2011;63(11):1535–42.

    Article  Google Scholar 

  18. McGonagle D, Tan AL, Carey J, Benjamin M. The anatomical basis for a novel classification of osteoarthritis and allied disorders. J Anat. 2010;216(3):279–91.

    Article  PubMed Central  PubMed  Google Scholar 

  19. Van Spil WE, Jansen NWD, Bijlsma JWJ, Reijman M, DeGroot J, Welsing PMJ, et al. Clusters within a wide spectrum of biochemical markers for osteoarthritis: data from CHECK, a large cohort of individuals with very early symptomatic osteoarthritis. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2012;20(7):745–54.

    Article  Google Scholar 

  20. Bay-Jensen AC, Slagboom E, Chen-An P, Alexandersen P, Qvist P, Christiansen C, et al. Role of hormones in cartilage and joint metabolism: understanding an unhealthy metabolic phenotype in osteoarthritis. Menopause N Y N. 2013;20(5):578–86.

    Google Scholar 

  21. Bos SD, Beekman M, Maier AB, Karsdal MA, Kwok W-Y, Bay-Jensen AC, et al. Metabolic health in families enriched for longevity is associated with low prevalence of hand osteoarthritis and influences OA biomarker profiles. Ann Rheum Dis. 2013;72(10):1669–74.

    Article  PubMed  Google Scholar 

  22. Gandhi R, Razak F, Davey JR, Mahomed NN. Metabolic syndrome and the functional outcomes of hip and knee arthroplasty. J Rheumatol. 2010;37(9):1917–22.

    Article  PubMed  Google Scholar 

  23. Zhuo Q, Yang W, Chen J, Wang Y. Metabolic syndrome meets osteoarthritis. Nat Rev Rheumatol. 2012;8(12):729–37.

    Article  CAS  PubMed  Google Scholar 

  24. Gelber AC, Hochberg MC, Mead LA, Wang NY, Wigley FM, Klag MJ. Body mass index in young men and the risk of subsequent knee and hip osteoarthritis. Am J Med. 1999;107(6):542–8.

    Article  CAS  PubMed  Google Scholar 

  25. Gelber AC, Hochberg MC, Mead LA, Wang NY, Wigley FM, Klag MJ. Joint injury in young adults and risk for subsequent knee and hip osteoarthritis. Ann Intern Med. 2000;133(5):321–8.

    Article  CAS  PubMed  Google Scholar 

  26. Attur M, Belitskaya-Lévy I, Oh C, Krasnokutsky S, Greenberg J, Samuels J, et al. Increased interleukin-1β gene expression in peripheral blood leukocytes is associated with increased pain and predicts risk for progression of symptomatic knee osteoarthritis. Arthritis Rheum. 2011;63(7):1908–17.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  27. Dolzani P, Assirelli E, Pulsatelli L, Addimanda O, Mancarella L, Peri G, et al. Systemic inflammation and antibodies to citrullinated peptides in hand osteoarthritis. Clin Exp Rheumatol. 2011;29(6):1006–9.

    PubMed  Google Scholar 

  28. Goldring MB, Berenbaum F. The regulation of chondrocyte function by proinflammatory mediators: prostaglandins and nitric oxide. Clin Orthop. 2004;(427 Suppl):S37–46.

    Google Scholar 

  29. Scanzello CR, Umoh E, Pessler F, Diaz-Torne C, Miles T, Dicarlo E, et al. Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2009;17(8):1040–8.

    Article  CAS  Google Scholar 

  30. Henriksen K, Karsdal MA, Martin TJ. Osteoclast-derived coupling factors in bone remodeling. Calcif Tissue Int. 2014;94(1):88–97.

    Article  CAS  PubMed  Google Scholar 

  31. Henriksen K, Neutzsky-Wulff AV, Bonewald LF, Karsdal MA. Local communication on and within bone controls bone remodeling. Bone. 2009;44(6):1026–33.

    Article  PubMed  Google Scholar 

  32. Karsdal MA, Leeming DJ, Dam EB, Henriksen K, Alexandersen P, Pastoureau P, et al. Should subchondral bone turnover be targeted when treating osteoarthritis? Osteoarthr Cartil OARS Osteoarthr Res Soc. 2008;16(6):638–46.

    Article  CAS  Google Scholar 

  33. Karsdal MA, Nielsen MJ, Sand JM, Henriksen K, Genovese F, Bay-Jensen A-C, et al. Extracellular matrix remodeling: the common denominator in connective tissue diseases. Possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure. Assay Drug Dev Technol. 2013;11(2):70–92.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  34. Attur M, Wang H-Y, Kraus VB, Bukowski JF, Aziz N, Krasnokutsky S, et al. Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations. Ann Rheum Dis. 2010;69(5):856–61.

    Article  PubMed Central  PubMed  Google Scholar 

  35. Dodd AW, Syddall CM, Loughlin J. A rare variant in the osteoarthritis-associated locus GDF5 is functional and reveals a site that can be manipulated to modulate GDF5 expression. Eur J Hum Genet EJHG. 2013;21(5):517–21.

    Article  CAS  PubMed  Google Scholar 

  36. Alexandersen P, Karsdal MA, Byrjalsen I, Christiansen C. Strontium ranelate effect in postmenopausal women with different clinical levels of osteoarthritis. Climacteric J Int Menopause Soc. 2011;14(2):236–43.

    Article  CAS  Google Scholar 

  37. Karsdal MA, Byrjalsen I, Henriksen K, Riis BJ, Lau EM, Arnold M, et al. The effect of oral salmon calcitonin delivered with 5-CNAC on bone and cartilage degradation in osteoarthritic patients: a 14-day randomized study. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2010;18(2):150–9.

    Article  CAS  Google Scholar 

  38. Reginster J-Y, Beaudart C, Neuprez A, Bruyère O. Strontium ranelate in the treatment of knee osteoarthritis: new insights and emerging clinical evidence. Ther Adv Musculoskelet Dis. 2013;5(5):268–76.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  39. Reginster J-Y. Efficacy and safety of strontium ranelate in the treatment of knee osteoarthritis: results of a double-blind randomised, placebo-controlled trial. Ann Rheum Dis. 2014;73(2):e8.

    Article  PubMed  Google Scholar 

  40. Spector TD, Conaghan PG, Buckland-Wright JC, Garnero P, Cline GA, Beary JF, et al. Effect of risedronate on joint structure and symptoms of knee osteoarthritis: results of the BRISK randomized, controlled trial [ISRCTN01928173]. Arthritis Res Ther. 2005;7(3):R625–33.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  41. Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001;69(3):89–95.

    Article  Google Scholar 

  42. Kraus VB, Burnett B, Coindreau J, Cottrell S, Eyre D, Gendreau M, et al. Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2011;19(5):515–42.

    Article  CAS  Google Scholar 

  43. Lotz M, Martel-Pelletier J, Christiansen C, Brandi M-L, Bruyère O, Chapurlat R, et al. Value of biomarkers in osteoarthritis: current status and perspectives. Ann Rheum Dis. 2013;72(11):1756–63.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  44. Van Spil WE, DeGroot J, Lems WF, Oostveen JCM, Lafeber FPJG. Serum and urinary biochemical markers for knee and hip-osteoarthritis: a systematic review applying the consensus BIPED criteria. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2010;18(5):605–12.

    Article  Google Scholar 

  45. Bauer DC, Hunter DJ, Abramson SB, Attur M, Corr M, Felson D, et al. Classification of osteoarthritis biomarkers: a proposed approach. Osteoarthr Cartil OARS Osteoarthr Res Soc. 2006;14(8):723–7.

    Article  CAS  Google Scholar 

  46. Jurisica I. Integrative cancer informatics for the identification of prognostic and predictive biomarkers. BMC Proc. 2013;7(Suppl 2 Sao Paulo Advanced School of Comparative Oncology: AbstractsClaudia Aparecida Rainho, Patricia Pintor dos Reis and Silvia Regina RogattoPublication of this supplement was funded by the Sao Paulo Research Foundation (FAPESP)):K7.

    Google Scholar 

  47. Zhu C-Q, Ding K, Strumpf D, Weir BA, Meyerson M, Pennell N, et al. Prognostic and predictive gene signature for adjuvant chemotherapy in resected non-small-cell lung cancer. J Clin Oncol Off J Am Soc Clin Oncol. 2010;28(29):4417–24.

    Article  CAS  Google Scholar 

  48. Frisenda S, Perricone C, Valesini G. Cartilage as a target of autoimmunity: a thin layer. Autoimmun Rev. 2013;12(5):591–8.

    Article  CAS  PubMed  Google Scholar 

  49. Nishioka K. Autoimmune response in cartilage-delivered peptides in a patient with osteoarthritis. Arthritis Res Ther. 2004;6(1):6–7.

    Article  PubMed  Google Scholar 

  50. Cooke TD. Significance of immune complex deposits in osteoarthritic cartilage. J Rheumatol. 1987;14 Spec No:77–9.

    Google Scholar 

  51. Gandhi R, Tsvetkov D, Dhottar H, Davey JR, Mahomed NN. Quantifying the pain experience in hip and knee osteoarthritis. Pain Res Manag J Can Pain Soc J Société Can Pour Trait Douleur. 2010;15(4):224–8.

    Google Scholar 

  52. Zhang W, Likhodii S, Zhang Y, Aref-Eshghi E, Harper PE, Randell E, et al. Classification of osteoarthritis phenotypes by metabolomics analysis. BMJ Open. 2014;4(11), e006286.

    Article  PubMed Central  PubMed  Google Scholar 

  53. Gaskell G, Gottweis H. Biobanks need publicity. Nature. 2011;471(7337):159–60.

    Article  CAS  PubMed  Google Scholar 

  54. Holzinger A, Dehmer M, Jurisica I. Knowledge discovery and interactive data mining in bioinformatics–state-of-the-art, future challenges and research directions. BMC Bioinformatics. 2014;15(Suppl 6):I1.

    Google Scholar 

  55. Fortney K, Jurisica I. Integrative computational biology for cancer research. Hum Genet. 2011;130(4):465–81.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  56. Jurisica I. Mapping cancer markers – towards precision medicine [Internet]. http://www.cs.toronto.edu/~juris/MCM.htm. Cited 5 Apr 2015.

  57. Starmans MH, Pintilie M, John T, Der SD, Shepherd FA, Jurisica I, et al. Exploiting the noise: improving biomarkers with ensembles of data analysis methodologies. Genome Med. 2012;4(11):84.

    Article  PubMed Central  PubMed  Google Scholar 

  58. Pastrello C, Pasini E, Kotlyar M, Otasek D, Wong S, Sangrar W, et al. Integration, visualization and analysis of human interactome. Biochem Biophys Res Commun. 2014;445(4):757–73.

    Article  CAS  PubMed  Google Scholar 

  59. Mullard A. 23andMe sets sights on UK/Canada, signs up Genentech. Nat Biotechnol. 2015;33(2):119.

    Article  CAS  PubMed  Google Scholar 

  60. Yim S-H, Chung Y-J. Reflections on the US FDA’s warning on direct-to-consumer genetic testing. Genomics Inform. 2014;12(4):151–5.

    Article  PubMed Central  PubMed  Google Scholar 

  61. Slade Shantz JA, Veillette CJH. The application of wearable technology in surgery: ensuring the positive impact of the wearable revolution on surgical patients. Front Surg. 2014;1:39.

    Article  PubMed Central  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Orthopaedic Surgery, Department of Surgery, Toronto Western Hospital, University Health Network, 399 Bathurst Street, East Wing Rm 1-440, Toronto, ON, M5T 2S8, Canada

    Christian J. H. Veillette MD, MSc, FRCSC

  2. University of Toronto, Toronto, ON, Canada

    Christian J. H. Veillette MD, MSc, FRCSC

  3. Princess Margaret Cancer Centre, University Health Network, IBM Life Sciences Discovery Centre, Toronto, ON, Canada

    Igor Jurisica PhD

Authors
  1. Christian J. H. Veillette MD, MSc, FRCSC
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Igor Jurisica PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Christian J. H. Veillette MD, MSc, FRCSC .

Editor information

Editors and Affiliations

  1. Division of Genetics and Development, Toronto Western Research Institute, University Health Network and Department of Surgery, University of Toronto, Toronto, Ontario, Canada

    Mohit Kapoor

  2. Division of Orthopaedics, Toronto Western Hospital, Toronto, Ontario, Canada

    Nizar N. Mahomed

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer International Publishing Switzerland

About this chapter

Cite this chapter

Veillette, C.J.H., Jurisica, I. (2015). Precision Medicine for Osteoarthritis. In: Kapoor, M., Mahomed, N. (eds) Osteoarthritis. Adis, Cham. https://doi.org/10.1007/978-3-319-19560-5_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-19560-5_13

  • Publisher Name: Adis, Cham

  • Print ISBN: 978-3-319-19559-9

  • Online ISBN: 978-3-319-19560-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation