Abstract
Yeast had participated with humans in food fermentation since the production of wine and bread, more than 10,000 years of shared history. It is well understood that fungi diversity is still underestimated and that we are far from understanding its importance and potential impact in biotechnology. Flavor compounds as “secondary metabolism” are very sensitive to fermentation conditions and mixed cultures, and although we had experience an exponential development of molecular biology in the last 30 years, metabolomics is still in its infancy. It was demonstrated in recent years that increase strain and species yeast diversity in a fermentation system increases sensory complexity and chemical aroma compound diversity in the final fermented product. Flavor compounds had many key functions for yeast, such as for survival and dispersion strategies, pheromone and defense mechanisms, and “quorum sensing” mechanisms for cell communication. Humans had taken advantage of many of these functions to increase taste and food sensory pleasure for a more exigent consumer, a phenomenon called “yeast domestication.” We focus this chapter mainly in the recent discussed yeast synthetic pathways for the formation of phenylpropanoid and terpenoid aroma compounds.
In addition, we will emphasize the current knowledge that grape and wine microbiology research has contributed to understand how complex natural and inoculated yeast flora can affect flavor quality. The flavor phenotype concept and how to screen natural flora and develop consortia starters to innovate in food biotechnology are discussed.
References
Pangborn RM (1964) Sensory evaluation of foods-look backward and forward. Food Technol 18:63–37
Peynaud É, Peynaud EPJ, Oenologue F, Oenologist F (1980) Le goût du vin. Dunod, Paris
Fleet GH (2003) Yeast interactions and wine flavour. Int J Food Microbiol 86:11–22
Medina K, Boido E, Fariña L et al (2013) Increased flavour diversity of Chardonnay wines by spontaneous fermentation and co-fermentation with Hanseniaspora vineae. Food Chem 141:2513–2521
Carrau F, Gaggero C, Aguilar PS (2015) Yeast diversity and native vigor for flavor phenotypes. Trends Biotechnol 33:148–154
Steensels J, Verstrepen KJ (2014) Taming wild yeast: potential of conventional and nonconventional yeasts in industrial fermentations. Annu Rev Microbiol 68:61–80
Cordente AG, Curtin CD, Varela C, Pretorius IS (2012) Flavour-active wine yeasts. Appl Microbiol Biotechnol 96:601–618
Bushdid C, Magnasco MO, Vosshall LB, Keller A (2014) Humans can discriminate more than 1 trillion olfactory stimuli. Science 343:1370–1372
Matsui A, Go Y, Niimura Y (2010) Degeneration of olfactory receptor gene repertories in primates: no direct link to full trichromatic vision. Mol Biol Evol 27:1192–1200
Dikicioglu D, Pir P, Oliver SG (2013) Predicting complex phenotype–genotype interactions to enable yeast engineering: Saccharomyces cerevisiae as a model organism and a cell factory. Biotechnol J 8:1017–1034
Schuller D (2010) Better yeast for better wine – genetic improvement of Saccharomyces cerevisiae wine strains. In: Rai M, Kövics G (eds) Progress in mycology. Springer, Netherlands, pp 1–49
Marullo P, Bely M, Masneuf-Pomarede I, Aigle M, Dubourdieu D (2004) Inheritable nature of enological quantitative traits is demonstrated by meiotic segregation of industrial wine yeast strains. FEMS Yeast Res 4:711–719
Hubmann G, Foulquié-Moreno MR, Nevoigt E et al (2013) Quantitative trait analysis of yeast biodiversity yields novel gene tools for metabolic engineering. Metab Eng 17:68–81
Bisson LF, Karpel JE (2010) Genetics of yeast impacting wine quality. Ann Rev Food Sci Technol 1:139–162
Takeoka G, Buttery RG, Flath RA, Teranishi R, Wheeler E, Wieczorek R, Guentert M (1989) Volatile constituents of pineapple (Ananas cosmus [L.] Merr). In: Teranishi R, Buttery RG, Shahidi F (eds) Flavor chemistry : trends and developments. ACS symposium series 388, American Chemical Society, Washington DC, 1989, pp 223–237
Rychlik M, Schieberle P, Grosch W (1998) Compilation of odor thresholds, odor qualities and retention indices of key food odorants. Deutsche Forschungsanstalt and Institut für Lebensmittelchemie der Technischen Universität München, Garching, Germany
Guth H (1997) Quantitation and sensory studies of character impact odorants of different white wine varieties. J Agric Food Chem 45:3027–3032
Ferreira V, López R, Cacho JF (2000) Quantitative determination of the odorants of young red wines from different grape varieties. J Sci Food Agric 80:1659–1667
Clean C (1996) MSDS. Safety data sheet. http://cleanandsolve.com/media/1044/safety-data-sheet-clean-and-solve.pdf
Akita O, Hasuo T, Hara S, Yoshizawa K (1988) Studies on the brewing of alcoholic beverage by the system of fermentation following after saccharification. IX: ethyl 4-hydroxybutyrate and y-butyrolactone in saké. Hakkokogaku Kaishi-J Soc Ferment Technol 66:149–155
Lambrechts MG, Pretorius IS (2000) Yeast and its importance to wine aroma a review. S Afr J Enol Vitic 21:97–129
Rapp A, Versini G (1996) Influence of nitrogen compounds in grapes on aroma compounds of wines. Vitic Enol Sci 51:193–203
Swiegers JH, Bartowsky PA, Henschke PA, Pretorius IS (2005) Yeast and bacterial modulation of wine aroma and flavour. Aust J Grape Wine Res 11:139–173
Carrau F, Medina K, Farina L, Boido E, Henschke PA, Dellacassa E (2008) Production of fermentation aroma compounds by Saccharomyces cerevisiae wine yeasts: effects of yeast assimilable nitrogen on two model strains. FEMS Yeast Res 8:1196–1207
Cozzolino D, Smyth HE, Lattey KA et al (2006) Combining mass spectrometry based electronic nose, visible-near infrared spectroscopy and chemometrics to assess the sensory properties of Australian Riesling wines Anal. Chim Acta 563:319–324
Ferreira V, Fernandez P, Cacho JF (1996) A study of factors affecting wine volatile composition and its application in discriminant analysis. Food Sci Technol 29:251–259
Guth H, Sies A (2002) Flavour of wines: towards an understanding by reconstitution experiments and an analysis of ethanol’s effect on odour activity of key compounds. In: Blair RJ, Williams PJ, Høj PB (eds) Proceedings of the 11th Australian wine industry technical conference. Adelaide, pp 128–139
Smyth HE, Cozzolino D, Herderich MJ, Sefton MA, Francis IL (2005) Relating volatile composition to wine aroma: identification of key aroma compounds in Australian white wines. In: Blair R, Williams P, Pretorius S (eds) Proceedings of the Twelfth Australian wine industry technical conference. Australian Wine Industry Technical Conference, Melbourne/Adelaide, pp 31–33
Pires EJ, Teixeira JA, Brányik T, Vicente AA (2014) Yeast: the soul of beer’s aroma – a review of flavour-active esters and higher alcohols produced by the brewing yeast. Appl Microbiol Biotechnol 98:1937–1949
Nordstrom K (1964) Studies on the formation of volatile esters in fermentation with brewer’s yeast. Sven Kem Tidskr 76:510–543
Reazin G, Scales H, Andreasen A (1970) Mechanism of major congener formation in alcoholic grain fermentations. J Agric Food Chem 18:585–589
Fariña L, Medina K, Urruty M, Boido E, Dellacassa E, Carrau F (2012) Redox effect on volatile compound formation in wine during fermentation by Saccharomyces cerevisiae. Food Chem 134:933–939
Nykanen L (1986) Formation and occurrence of flavour compounds in wine and distilled alcoholic beverages. Am J Enol Vitic 37:84–96
Muller CJ, Kepner RE, Webb AD (1973) Lactones in wines. Am J Enol Vitic 24:5–9
Vos PJA, Gray RS (1979) The origin and control of hydrogen sulfide during fermentation of grape must. Am J Enol Vitic 30:187–197
Bell SJ, Henschke PA (2005) Implications of nitrogen nutrition for grapes, fermentation and wine. Aust J Grape Wine Res 11:242–295
Ugliano M, Fedrizzi B, Siebert T, Travis B, Magno F, Versini G, Henschke PA (2009) Effect of nitrogen supplementation and Saccharomyces species on hydrogen sulfide and other volatile sulfur compounds in Shiraz fermentation and wine. J Agric Food Chem 57:4948–4955
Escudero A, Campo E, Fariña L, Cacho J, Ferreira V (2007) Analytical characterization of the aroma of five premium red wines. Insights into the role of odor families and the concept of fruitiness of wines. J Agric Food Chem 55:4501–4510
Kinzurik MI, Herbst-Johnstone M, Gardner RC, Fedrizzi B (2015) Evolution of volatile sulfur compounds during wine fermentation. J Agric Food Chem 63:8017–8024
Hjelmeland AK, Ebeler SE (2015) Glycosidically bound volatile aroma compounds in grapes and wine: a review. Am J Enol Vitic 66:1–11.
Boido E, Lloret A, Medina K, Farñia L, Carrau F, Versini G, Dellacassa E (2003) Aroma composition of Vitis vinifera cv. Tannat: the typical red wine from Uruguay. J Agric Food Chem 51:5408–5413
Fang Y, Qian MC (2006) Quantification of selected aroma-active compounds in Pinot noir wines from different grape maturities. J Agric Food Chem 54:8567–8573
González-Barreiro C, Rial-Otero R, Cancho-Grande B, Simal-Gándara J (2013) Wine aroma compounds in grapes: a critical review. Crit Rev Food Sci Nutr 55:202–218
Robinson AL, Boss PK, Solomon PS, Trengove RD, Heymann H, Ebeler SE (2014) Origins of grape and wine aroma. Part 1. Chemical components and viticultural impacts. Am J Enol Vitic 65:1–24
Sefton M, Francis I, Williams P (1993) The volatile composition of Chardonnay juices: a study by flavor precursor analysis. Am J Enol Vitic 44:359–370
Francis IL, Kassara S, Noble AC, Williams PJ (1998) The contribution of glycoside precursors to cabernet sauvignon and merlot aroma: sensory and compositional studies. In: Waterhouse A, Ebeler S (eds) Chemistry of wine flavor, ACS symposium series. American Chemical Society, Washington, DC, pp 13–30
Versini G, Carlin S, Nicolini G, Dellacassa E, Carrau F (1999) Updating of varietal aroma components in wines. In: Mendoza, Argentina: VII Latinamerican congress of enology and viticulture. Asociacion de Enologos de Argentina, Argentina, pp 325–349
Günata ZY, Bitteur S, Brillouet J-M, Bayonove CL, Cordonnier RE (1988) Sequential enzymic hydrolysis of potentially aromatic glycosides from grapes. Carbohydr Res 184:139–149
Günata Z, Blondeel C, Vallier MJ, Lepoutre JP, Sapis JC, Watanabe N (1998) An endoglycosidase from grape berry skin of cv. M. Alexandria hydrolyzing potentially aromatic disaccharide glycosides. J Agric Food Chem 46:2748–2753
Ugliano M, Bartowsky EJ, McCarthy J, Moio L, Henschke PA (2006) Hydrolysis and transformation of grape glycosidically bound volatile compounds during fermentation with three Saccharomyces yeast strains. J Agric Food Chem 54:6322–6331
Palmeri R, Spagna G (2007) β-Glucosidase in cellular and acellular form for winemaking application. Enzyme Microb Technol 40:382–389
Sarry J-E, Günata YZ (2004) Plant and microbial glycoside hydrolases: volatile release from glycosidic aroma precursors. Food Chem 87:509–521
Ayran AP, Wilson B, Strauss CR, Williams PJ (1987) The properties of glycosidases of Vitis vinifera and a comparison of their β-glucosidase activity with that of exogenous enzymes. An assessment of possible applications in enology. Am J Enol Vitic 38:182–188
Günata YZ, Bayonove CL, Tapiero C, Cordonnier RE (1990) Hydrolysis of grape monoterpenyl β-d-glucosides by various β-glucosidases. J Agric Food Chem 38:1232–1236
Biron C, Cordonnier R, Glory O, Günata Z, Sapis JC (1988) Étude, dans le raisin, de l’activité β-glucosidase. Connaissance de la Vigne et du Vin 22:125–134
Lecas M, Günata ZY, Sapis J-C, Bayonove L (1991) Purification and partial characterization of β-glucosidase from grape. Phytochemistry 30:451–454
Williams PJ (1993) Hydrolytic flavor release in fruit and wines through hydrolysis of nonvolatile precursors. In: Acree TE, Teranishi R (eds) Flavor science – sensible principles and techniques. American Chemical Society, Washington, DC, pp 287–303
Manzanares P, Rojas V, Genovés S, Vallés S (2000) A preliminary search for anthocyanin-β-d-glucosidase activity in non-Saccharomyces wine yeasts. Int J Food Sci Technol 2000:95–103
McMahon H, Zoecklein BW, Fugelsang K, Jasinski Y (1999) Quantification of glycosidase activities in selected yeast and lactic acid bacteria. J Ind Microbiol Biotechnol 23:198–203
Riccio P, Rossano R, Vinella M et al (1999) Extraction and immobilization in one-step of two β-glucosidases released from a yeast strain of Debaryomyces hansenii. Enzyme Microb Technol 24:123–129
Rosi I, Vinella M, Domizio P (1994) Characterization of β-glucosidase activity in yeast of oenological origin. J Appl Bacteriol 77:519–527
Strauss ML, Jolly NP, Lambrechts MG, Renault P (2001) Screening for the production of extracellular hydrolytic enzymes by non-Saccharomyces wine yeasts. J Appl Microbiol 91:182–190
Bisotto A, Julien A, Rigou P, Schneider R, Salmon J (2015) Evaluation of the inherent capacity of commercial yeast strains to release glycosidic aroma precursors from Muscat grape must. Aust J Grape Wine Res 21:194–199
Ciani M, Piccioti G (1995) The growth kinetics and fermentation behavior of some non-Saccharomyces yeast associated with winemaking. Biotechnol Lett 17:1247–1250
Fleet GH (1992) Spoilage yeast. CRC Crit Rev Biotechnol 12:1–44
Calabretti A, La Cara F, Sorrentino A et al (2012) Characterization of volatile fraction of typical Irpinian wines fermented with a new starter yeast. World J Microbiol Biotechnol 28:1433–1442
Pérez G, Fariña L, Barquet M, Boido E, Gaggero C, Dellacassa E, Carrau F (2011) A quick screening method to identify β-glucosidase activity in native wine yeast strains: Application of Esculin Glycerol Agar (EGA) medium. World J Microbiol Biotechnol 27:47–55
Williams PJ, Cynkar W, Francis IL, Gray JD, Iland PG, Coombe BG (1995) Quantification of glycosides in grapes, juices and wines through a determination of glycosyl-glucose. J Agric Food Chem 43:121–128
Chassagne D, Vernizeau S, Nedjmac M, Alexandre H (2005) Hydrolysis and sorption by Saccharomyces cerevisiae strains of Chardonnay grape must glycosides during fermentation. Enzyme Microb Technol 37:212–217
Zoecklein BW, Marcy JE, Williams JM, Jasinski Y (1997) Effect of native yeasts and selected strains of Saccharomyces cerevisiae on glycosyl glucose, potential volatile terpenes, and selected aglycones of white riesling (Vitis vinifera L.) wines. J Food Compos Anal 10:55–65
Darriet P, Boidron J-N, Dubourdieu D (1988) L’hydrolyse des hétérosides terpéniques du Muscat a Petits Grains par les enzymes périplasmiques de Saccharomyces cerevisiae. Connaissance de la Vigne et du Vin 22:189–195
Delcroix A, Günata Z, Sapis J-C, Salmon J-M, Bayonove C (1994) Glycosidase activities of three enological yeast strains during winemaking: effect on the terpenol content of Muscat wine. Am J Enol Vitic 45:291–296
Charoenchai C, Fleet GH, Henschke PA, Todd BEN (1997) Screening of non-Saccharomyces wine yeasts for the presence of extracellular hydrolytic enzymes. Aust J Grape Wine Res 3:2–8
Gueguen Y, Chemardin P, Arnaud A, Galzy P (1995) Comparative study of extracellular and intracellular b-glucosidases of a new strain of Zygosaccharomyces bailii isolated from fermenting agave juice. J Appl Bacteriol 78:270–280
Vasserot Y, Christiaens H, Chemardin P, Arnaud A, Galzy P (1989) Purification and properties of a β-glucosidase of Hanseniaspora vineae Van der Walt and Tscheuschner with the view to its utilization in fruit aroma liberation. J Appl Bacteriol 66:271–279
Yanai T, Sato M (1999) Isolation and properties of β-glucosidase produced by Debaryomyces hansenii and its application in winemaking. Am J Enol Vitic 50:231–235
Gueguen Y, Chemardin P (1996) A very efficient β-glucosidase catalyst for the hydrolysis of flavor precursors of wines and fruit juices. J Agric Food Chem 44:2336–2340
Madrigal T, Maicas S, Tolosa JJM (2013) Glucose and ethanol tolerant enzymes produced by Pichia (Wickerhamomyces) isolates from enological ecosystems. Am J Enol Vitic 64:126–133
González-Pombo P, Pérez G, Carrau F, Guisán JM, Batista-Viera F, Brena BM (2008) One-step purification and characterization of an intracellular β-glucosidase from Metschnikowia pulcherrima. Biotechnol Lett 30:1469–1475
Barbagallo RN, Spagna G, Palmeri R, Restuccia C, Giudici P (2004) Selection, characterization and comparison of β-glucosidase from mould and yeasts employable for enological applications. Enzyme Microb Technol 35:58–66
Gueguen Y, Chemardin P, Arnaud A, Galzy P (1995) Comparative study of extracellular and intracellular β-glucosidases of a new strain of Zygosaccharomyces bailii isolated from fermenting agave juice. J Appl Bact 78:270–280
Turan Y, Zheng M (2005) Purification and characterization of an intracellular β-glucosidase from the methylotrophic yeast Pichia pastoris. Biochemistry (Moscow) 70:1363–1368
Palmeri R, Spagna G (2007) β-Glucosidase in cellular and acellular form for winemaking application. Enz Microb Technol 40:382–389
Belancic A, Gunata Z, Vallier M-J, Agosin E (2003) β-Glucosidase from the grape native yeast Debaryomyces vanrijiae: purification, characterization, and its effect on monoterpene content of a Muscat grape juice. J Agric Food Chem 51:1453–1459
González-Pombo P, Fariña L, Carrau F, Batista-Viera F, Brena BM (2011) A novel extracellular β-glucosidase from Issatchenkia terricola: Isolation, immobilization and application for aroma enhancement of white Muscat wine. Process Biochem 46:385–389
Henschke PA, Jiranek V (1993) Yeast: metabolism of nitrogen compounds. In: Fleet GH (ed) Wine microbiology and biotechnology. Harwood Academic Publishers, GmbH, Chur-London-New York, pp 77–164
Rapp A, Güntert M (1985) Changes in aroma substances during the storage of white wines in bottles. In: Charalambous G (ed) 4th International flavor conference. in the shelf life of foods and beverages. Rhodes, pp 141–167
Rapp A, Güntert M, UH Z (1985) Changes in aroma substances during the storage in bottles of white wines of the Riesling variety. Lebensm Unters Forsch 180:109–116
Cheng AX, Lou YG, Mao YB, Lu S, Wang LJ, Chen XY (2007) Plant terpenoids: biosynthesis and ecological functions. J Integr Plant Biol 49:179–186
Dudareva N, Negre F, Nagegowda DA, Orlova I (2006) Plant volatiles: recent advances and future perspectives. Crit Rev Plant Sci 25:417–444
Dudareva N, Pichersky E, Gershenzon J (2004) Biochemistry of plant volatiles. Plant Physiol 135:1893–1902
Verpoorte R, Alfermann AW (2000) Metabolic engineering of plant secondary metabolism. Kluwer, Dordrecht, pp 1–30
Page JE, Hause G, Raschke M (2004) Functional analysis of the final steps of the 1-deoxy-D-xylulose 5-phosphate (DXP) pathway to isoprenoids in plants using virus-induced gene silencing. Plant Physiol 134:1401–1413
Gershenzon J, Kreis W (1999) Biochemistry of terpenoids: monoterpenes, sesquiterpenes, diterpenes, sterols, cardiac glycosides and steroid saponins. In: Wink M (ed) Biochemistry of plant secondary metabolism. CRC Press, Boca Raton, pp 222–299
Paschold A, Halitschke R, Baldwin IT (2006) Using ‘mute’ plants to translate volatile signals. Plant J 45:275–291
Rodriguez-Concepcion M, Boronat A (2002) Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics. Plant Physiol 130:1079–1089
Bochar DA, Friesen JA, Stauffacher CV, Rodwell VW (1999) Isoprenoids including steroids and carotenoids. In: Cane DE (ed) Comprehensive natural product chemistry. Pergamon Press, Tarrytown, pp 15–44
Rohmer M (1999) The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher plants. Nat Prod Rep 16:565–574
Rohmer M, Knani M, Simonin P, Sutter B, Sahm H (1993) Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate. Biochem J 295:517–524
Rohmer M, Seemann M, Horbach S, Bringer-Meyer S, Sahm H (1996) Glyceraldehyde 3-phosphate and pyruvate as precursors of isoprenic units in an alternative non-mevalonate pathway for terpenoid biosynthesis. J Am Chem Soc 118:2564–2566
De Carvalho CR, Da Fonseca MR (2006) Biotransformation of terpenes. Biotechnol Adv 24:134–142
Fernandez-Gonzalez M, Di Stefano R, Briones A (2003) Hydrolysis and transformation of terpene glycosides from muscat must by different yeast species. Food Microbiol 20:35–41
Ramey DD (1995) Low input winemaking: let nature do the work. In: Ninth Australian wine industry technical conference. Adelaide, pp 26–29
Carrau FM (2005) Levaduras nativas para Enologia de Minima Intervencion. Biodiversidad, Seleccion y Caracterizacion. Agrociencia 9:387–399
Heard G, Fleet G (1986) Occurrence and growth of yeast species during the fermentation of some Australian wines. Food Technol Aust 38:22–25
Gramatica P, Manitto P, Ranzi PM, Delbianco A, Francavilla M (1982) Stereospecific reduction of geraniol to (R.)-(+)-citronellol by Saccharomyces cerevisiae. Experientia 38:775–776
King A, Dickinson JR (2000) Biotransformation of monoterpene alcohols by Saccharomyces cerevisiae, Torulaspora delbrueckii and Kluyveromyces lactis. Yeast 16:499–506
Corey EJ, Matsuda SPT, Bartel B (1994) Molecular cloning, characterization, and overexpression of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthase. Proc Natl Acad Sci U S A 91:2211–2215
Lynen F (1964) The pathway from “activated acetic acid” to the terpenes and fatty acids. In: Royal caroline institute, pp 103–138. www.nobel.se/medicine/laureates/1964/lynen-lecture.pdf
Ratledge C, Evans CT (1989) Lipids and their metabolism. In: The yeasts. Academic, London, pp 367–455
Huang H-R, Xia X-K, She Z-G, Lin Y-C, Vrijmoed L, Gareth JE (2006) A new chloro-monoterpene from the mangrove endophytic fungus Tryblidiopycnis sp. (4275). J Asian Nat Prod Res 8:609–612
Liu J, Zhang W, Du G, Chen J, Zhou J (2013) Overproduction of geraniol by enhanced precursor supply in Saccharomyces cerevisiae. J Biotechnol 168:446–451
Lanza E, Palmer JK (1977) Biosynthesis of monoterpenes by Ceratocystis moniliformis. Phytochem 16:1555–1560
Hornby JM, Jensen EC, Lisec AD et al (2001) Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl Environ Microbiol 67:2982–2992
Martins M, Henriques M, Azeredo J, Rocha SM, Coimbra MA, Oliveira R (2010) Candida species extracellular alcohols: production and effect in sessile cells. J Bas Microbiol 50:S89–S97
Nishino T, Suzuki N, Katsuki H (1982) Enzymatic formation of nerolidol in cell-free extract of Rhodotorula glutinis. J Biochem 92:1731–1740
Wang C, Kim J-Y, Choi E-S, Kim S-W (2011) Microbial production of farnesol (FOH): current states and beyond. Process Biochem 46:1221–1229
Anderson MS, Yarger J, Burck C, Poulter C (1989) Farnesyl diphosphate synthetase. Molecular cloning, sequence, and expression of an essential gene from Saccharomyces cerevisiae. J Biol Chem 264:19176–19184
Chambon C, Ladeveze V, Oulmouden A, Servouse M, Karst F (1990) Isolation and properties of yeast mutants affected in farnesyl diphosphate synthetase. Curr Genet 18:41–46
Fischer MJ, Meyer S, Claudel P, Bergdoll M, Karst F (2011) Metabolic engineering of monoterpene synthesis in yeast. Biotechnol Bioeng 108:1883–1892
Disch A, Rohmer M (1998) On the absence of the glyceraldehyde 3-phosphate pyruvate pathway for isoprenoid biosynthesis in fungi and yeasts. FEMS Microbiol Lett 168:201–208
Carrau F, Medina K, Boido E et al (2005) De novo synthesis of monoterpenes by Saccharomyces cerevisiae wine yeasts. FEMS Microbiol Rev 243:107–115
Drawert F, Barton J (1978) Biosynthesis of flavor compounds by microorganisms. Production of monoterpenes by the yeast Kluyveromyces lactis. J Agric Food Chem 26:765–767
Fagan GL, Kepner RE, Webb AD (1981) Production of linalool, cis-nerolidol and trans-farnesol by Saccharomyces fermentati growing as a film on simulated wine. Vitis 20:36–42
Hock R, Benda I, Schreier P (1984) Formation of terpenes by yeast during alcoholic fermentation. ZLebenUnter Forschung 179:450–452
Klingenberg A, Sprecher E (1985) Production of monoterpenes in liquid cultures by the yeast Ambrosiozyma monospora. Planta Med 3:264–265
Jackson BE, Hart-Wells EA, Matsuda SPT (2003) Metabolic engineering to produce sesquiterpenes in yeast. Org Lett 5:1629–1632
Ro D-K, Paradise EM, Ouelle M et al (2006) Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature 440:940–943
Takahashi S, Yeo Y, Greenhagen BT et al (2007) Metabolic engineering of sesquiterpene metabolism in yeast. Biotechnol Bioeng 97:170–181
Casey WM, Keesler GA, Parks L (1992) Regulation of partitioned sterol biosynthesis in Saccharomyces cerevisiae. J Bacteriol 174:7283–7288
Bejarano ER, Cerdá-Olmedo E (1992) Independence of the carotene and sterol pathways of phycomyces. FEBS Lett 306:209–212
Domenech CE, Giordano W, Avalos J, Cerdá-olmedo E (1996) Separate compartments for the production of sterols, carotenoids and gibberellins in Gibberella fujikuroi. Eur J Biochem 239:720–725
Lanza E, Palmer JK (1977) Biosynthesis of monoterpenes by Ceratocystis moniliformis. Phytochemistry 16:1555–1560
Spurgeon SL, Porter JW (1981) Introduction. In: Porter JW, Spurgeon SL (eds) Biosynthesis of isoprenoid compounds. Wiley, New York, pp 1–46
Rodríguez JM, Ruiz-Sala P, Ugarte M, Peñalva MA (2004) Fungal metabolic model for 3-Methylcrotonyl-CoA carboxylase deficiency. J Biol Chem 279:4578–4587
Anderson MD, Che P, Song J, Nikolau BJ, Wurtele ES (1998) 3-methylcrotonyl coenzyme A carboxylase is a component of the mitochondrial leucine catabolic pathway. Plant Physiol 118:1127–1138
Moss J, Lane MD (1971) The biotin-dependent enzymes. Advances in enzymology relat. Areas Mol Biol 35:321–442
Camesasca L, Minteguiaga M, Faruña L, Salzman V, Carrau F, Aguilar PS, Gaggero C (2014) COQ1 overexpression in Saccharomyces cerevisiae results in increased levels of isoprenoides. In: Annual meeting American society for microbiology. ASM, Boston
Oswald M, Fischer M, Dirninger N, Karst F (2007) Monoterpenoid biosynthesis in Saccharomyces cerevisiae. FEMS Yeast Res 7:413–421
Chambon C, Ladeveze V, Servouse M, Blanchard L, Javelot C, Vladescu B, Karst F (1991) Sterol pathway in yeast. Identification and properties of mutant strains defective in mevalonate diphosphate decarboxylase and farnesyl diphosphate synthetase. Lipids 26:633–636
Lichtenthaler HK, Rohmer M, Schwender J (1997) Two independent biochemical pathways for isopentenyl diphosphate and isoprenoid biosynthesis in higher plants. Physiol Plant 101:643–652
Faulkner A, Chen X, Rush J, Horazdovsky B, Waechter CJ, Carman GM, Sternweis PC (1999) The LPP1 and DPP1 gene products account for most of the isoprenoid phosphate phosphatase activities in Saccharomyces cerevisiae. J Biol Chem 274:14831–14837
Giorello F, Salzman VM et al (2014) Application of Hanseniaspora vineae strains. Searching for genes to explain increased flavor complexity in wines. In: International symposium specialized on yeasts, ISSY31. Vipava, p 39
Widhalm JR, Dudareva N (2015) A familiar ring to it: biosynthesis of plant benzoic acids. Mol Plant 8:83–97
Scognamiglio J, Jones L, Vitale D, Letizia C, Api A (2012) Fragrance material review on benzyl alcohol. Food Chem Toxicol 50:S140–S160
Guillen F, Martinez AT, Martinez MJ (1992) Substrate specificity and properties of the aryl-alcohol oxidase from the ligninolytic fungus Pleurotus eryngii. Eur J Biochem 209:603–611
Chen H, Fink GR (2006) Feedback control of morphogenesis in fungi by aromatic alcohols. Genes Dev 20:1150–1161
Bosse AK, Fraatz MA, Zorn H (2013) Formation of complex natural flavours by biotransformation of apple pomace with basidiomycetes. Food Chem 141:2952–2959
Delfini C, Gaia P, Bardi L, Mariscalco G, Contiero M, Pagliara A (1991) Production of benzaldehyde, benzyl alcohol and benzoic acid by yeasts and Botrytis cinerea isolated Ïrom grape musts and wines. Vitis 30:253–263
Meganathan R (2001) Ubiquinone biosynthesis in microorganisms. FEMS Microbiol Rev 203:131–139
Orlova I, Marshall-Colón A, Schnepp J et al (2006) Reduction of benzenoid synthesis in petunia flowers reveals multiple pathways to benzoic acid and enhancement in auxin transport. Plant Cell 18:3458–3475
Hyun MW, Yun YH, Kim JY, Kim SH (2011) Fungal and plant phenylalanine ammonia-lyase. Mycobiology 39:257–265
Uchiyama K, Kawaguchi K, Tochikura T, Ogata K (1969) Metabolism of aromatic amino acids in microorganisms: part III. Metabolism of cinnamic acid in Rhodotorula. Agric Biol Chem 33:755–763
Martin V, Boido E, Giorello F, Mas A, Dellacassa E, Carrau F (2015) Syntheses of phenolic aroma compounds by Hanseniaspora vineae yeast strains contribute to increase flavor diversity of wines. In: International symposium specialized on yeasts, ISSY31. Perugia, p 30
Giorello FM, Berná L, Greif G et al (2014) Genome sequence of the native apiculate wine yeast Hanseniaspora vineae T02/19AF. Gen Announce 2(3):e00530-14
Jolly NP, Augustyn OPH, Pretorius IS (2006) The role and use of non-Saccharomyces yeasts in wine production. S Afr J Enol Vitic 27:15–39
Romano P, Suzzi G, Domizio P, Fatichenti F (1997) Secondary products formation as a tool for discriminating non-Saccharomyces wine strains. Anton Leeuw Int J Gen Mol Microbiol 71:239–242
Fleet GH (2008) Wine yeasts for the future. FEMS Yeast Res 8:979–995
Ciani M, Comitini F, Mannazzu I, Domizio P (2010) Controlled mixed culture fermentation: a new perspective on the use of non-Saccharomyces yeasts in winemaking. FEMS Yeast Res 10:123–133
Zott K, Miot-Sertier C, Claisse O, Lonvaud-Funel A, Masneuf-Pomarede I (2008) Dynamics and diversity of non-Saccharomyces yeasts during the early stages in winemaking. Int J Food Microbiol 125:197–203
Medina K, Boido E, Dellacassa E, Carrau F (2012) Growth of non-Saccharomyces yeasts affects nutrient availability for Saccharomyces cerevisiae during wine fermentation. Int J Food Microbiol 157:245–250
Anfang N, Brajkovich M, Goddard MR (2009) Co-fermentation with Pichia kluyveri increases varietal thiol concentrations in Sauvignon blanc. Aust J Grape Wine Res 15:1–8
Carrau F (2006) Native yeasts for low input winemaking: searching for wine diversity and increased complexity. In: University CS (ed) International wine microbiology symposium. California State University, Tenaya Lodge, pp 33–39
Barbosa C, Mendes-Faia A, Lage P, Mira NP, Mendes-Ferreira A (2015) Genomic expression program of Saccharomyces cerevisiae along a mixed-culture wine fermentation with Hanseniaspora guilliermondii. Microb Cell Fact 14:1–17
Jolly NP, Augustyn OPH, Pretorius IS (2003) The effect of non-Saccharomyces yeasts on fermentation and wine quality. S Afr J Enol Vitic 24:55–62
Egli CM, Edinger WD, Mitrakul CM, Henick-Kling T (1998) Dynamics of indigenous and inoculated yeast populations and their effect on the sensory character of Riesling and Chardonnay wines. J Appl Microbiol 85:779–789
Andorrà I, Berradre M, Mas A, Esteve-Zarzoso B, Guillamón JM (2012) Effect of mixed culture fermentations on yeast populations and aroma profile. LWT-Food Sci Technol 49:8–13
Sadoudi M, Tourdot-Maréchal R, Rousseaux S et al (2012) Yeast–yeast interactions revealed by aromatic profile analysis of Sauvignon Blanc wine fermented by single or co-culture of non-Saccharomyces and Saccharomyces yeasts. Food Microbiol 32:243–253
Carrau F (2003) Characterization of yeast in relation to the ability to utilize nitrogen – studies of aroma compounds. In: Food science and technology. Universidad de la Republica, Montevideo, p 296
Agenbach WA (1977) A study of must nitrogen content in relation to incomplete fermentations, yeast production and fermentation activity. In: Proceedings of the South African society for enology and viticulture. Stellenbosch, pp 66–88
Bell AA, Ough CS, Kliewer WM (1979) Effects on must and wine composition rates of fermentation, and wine quality of nitrogen fertilization of Vitis vinifera var. Thompson seedless grapevines. Am J Enol Vitic 30:124–129
Antonelli A, Castellari L, Zambonelli C, Rossi C (1999) Yeast influence on volatile composition of wines. J Agric Food Chem 47:1139–1144
Cabrera MJ, Morero J, Ortega JM, Medina M (1988) Formation of ethanol, higher alcohols, esters and terpenes by five strains in musts from Pedro Ximenez grapes in various degrees of ripeness. Am J Enol Vitic 39:283–287
Cavazza A, Versini G, Dalla Serra A, Romano F (1989) Characterization of six S. cerevisiae strains on the basis of their volatile compound production, as found in wines of different aroma profiles. Yeast 5:163–167
Daudt CE, Ough CS (1973) A method for quantitative measurement of volatile acetate esters from wine. Am J Enol Vitic 24:125–129
Deleteil D, Jarry JM (1992) Characteristic effects of two commercial yeast strains on chardonnay wine volatiles and polysaccharide composition. Wine Ind J 2:29–33
Di Stefano R, Ciolfi G, Delfini C (1981) Composti volatili prodotti dei lieviti. Rivista Viticultura Enologia 34:342–347
Gil J, Mateo J, Jimenez M, Pastor A, Huerta T (1996) Aroma compounds in wine as influenced by apiculate yeasts. J Food Sci 61:1247–1266
Giudici P, Romano P, Zambonelli C (1990) A biometric study of higher alcohol production in Saccharomyces cerevisiae. Can J Microbiol 36:61–64
Herraiz T, Reglero G, Herraiz M, Martin-Alvarez PJ, Cabezudo MD (1990) The influence of the yeast and type of culture on the volatile composition of wines fermented without sulfur dioxide. Am J Enol Vitic 41:313–318
Lema C, Garcia-Jares C, Orriols I, Angulo L (1996) Contribution of Saccharomyces and non-Saccharomyces populations to the production of some components of Albarin˜o wine aroma. Am J Enol Vitic 47:206–216
Longo E, Velazquez JB, Sieiro C, Cansado J, Calo P, Villa TG (1992) Aroma compounds of Saccharomyces cerevisiae wine strains isolated from the Salnes region (Galicia, Spain). World J Microbiol Biotechnol 8:539–541
Lurton I, Snakkers G, Roulland C, Galy B, Versavaud A (1995) Influence of the fermentation yeast strain on the composition of wine spirits. J Sci Food Agric 67:485–491
Mateo J, Jimenez M, Huerta T, Pastor A (1991) Contribution of different yeasts isolated from musts of monastrell grapes to the aroma of wine. Int J Food Microbiol 14:153–160
Rankine BC (1967) Influence of yeast strain and pH on pyruvic acid content of wines. J Sci Food Agric 18:41–44
Rankine BC, Pocock KF (1969) Influence of yeast strain on binding of sulphur dioxide in wines, and on its formation during fermentation. J Sci Food Agric 20:104–109
Romano P, Fiore C, Paraggio M, Caruso M, Carece A (2003) Function of yeast species and strains in wine flavour. Int J Food Microbiol 86:169–180
Vila I, Sablayrolles JM, Gerland C, Baumes R, Bayonove C, Barre P (2000) Comparison of “aromatic” and “neutral” yeast strains: influence of vinification conditions. Wein-Wiss 55:59–66
Jiranek V, Langridge P, Henschke PA (1991) Yeast nitrogen demand: selection criterion for wine yeasts for fermenting low nitrogen musts. In: Rantz JM (ed) Proceedings of the international symposium on nitrogen in grapes wine. ASEV, Seattle, Washington, DC, pp 266–269
Taillandier P, Portugala FR, Fuster A, Strehaiano P (2007) Effect of ammonium concentration on alcoholic fermentation kinetics by wine yeasts for high sugar content. Food Microbiol 24:95–100
Beltran G, Esteve-Zarzoso B, Rozes N, Mas A, Guillamon JM (2005) Influence of the timing of nitrogen additions during synthetic grape must fermentations on fermentation kinetics and nitrogen consumption. J Agric Food Chem 53:996–1002
Bosso A (1996) Influenza dell`aggiunta di dosi crescenti di azoto ammoniacale ai mosti sulla composizione in sostanze volatili di origine fermentativa e sulle principali caratteristiche olfattive di alcuni vini bianchi. Rivista Viticultura Enologia 3:3–28
Guitart A, Hernandez Orte P, Ferreira V, Pena C, Cacho J (1999) Some observations about the correlation between the amino acid content of musts and wines of the Chardonnay variety and their fermentation aromas. Am J Enol Vitic 50:253–258
Hernandez-Orte P, Bely M, Cacho J, Ferreira V (2006) Impact of ammonium additions on volatile acidity, ethanol, and aromatic compound production by different Saccharomyces cerevisiae strains during fermentation in controlled synthetic media Aust. J Grape Wine Res 12:150–160
Nicolini G, Mocchiutti R, Larcher R, Moser S (2000) Lieviti ed aromi dei vini: comparazione tra ceppi commerciali di larga diffusione. L´Enotecnico 36:75–85
Nicolini G, Volonterio G, Larcher R, Moser S, Dalla Serra A (2000) Prestazioni fermmentative ed aromatiche di lieviti sudafricani di recente immissioe in Italia. L´Enotecnico 36:87–94
Carrau FM, Medina K, Boido E et al (2005) De novo synthesis of monoterpenes by Saccharomyces cerevisiae wine yeasts. FEMS Microbiol Lett 243:107–115
Vilanova M, Ugliano M, Varela C, Siebert T, Pretorius IS, Henschke PA (2007) Assimilable nitrogen utilisation and production of volatile and non-volatile compounds in chemically defined medium by Saccharomyces cerevisiae wine yeasts. Appl Microbiol Biotechnol 77:145–157
Buzzini P, Martini A, Cappelli F, Pagnoni UM, Davoli P (2003) A study on volatile organic compounds (VOCs) produced by tropical ascomycetous yeasts. Ant van Leeuwen 84:301–311
Backhus LE, DeRisi J, Brown P, Bisson LF (2001) Functional genomic analysis of a commercial wine strain of Saccharomyces cerevisiae under differing nitrogen conditions. FEMS Yeast Res 1:111–125
Steensels J, Snoek T, Meersman E, Nicolino MP, Voordeckers K, Verstrepen KJ (2014) Improving industrial yeast strains: exploiting natural and artificial diversity. FEMS Microbiol 38:947–995
Fischer MJC, Meyer S, Claudel P, Bergdoll M, Karst F (2011) Metabolic engineering of monoterpene synthesis in yeast. Biotechnol Bioengin 108:1883–1892
Swiegers JH, Capone DL, Pardon KH, Elsey GM, Sefton MA, Francis IL, Pretorius IS (2007) Engineering volatile thiol release in Saccharomyces cerevisiae for improved wine aroma. Yeast 24:561–574
Sarma SJ, Verma M, Brar SK (2013) Industrial fermentation for production of alcoholic beverages. In: Soccol CR, Pandey A, Larroche C. Fermentation processes engineering in the Food industry. CRC Press, Boca Raton, FL, pp 299–322
Dufour M, Zimmer A, Thibon C, Marullo P (2013) Enhancement of volatile thiol release of Saccharomyces cerevisiae strains using molecular breeding. Appl Microbiol Biotechnol 97:5893–5905
Bellon JR, Schmid F, Capone DL, Dunn BL, Chambers PJ (2013) Introducing a new breed of wine yeast: interspecific hybridisation between a commercial Saccharomyces cerevisiae wine yeast and Saccharomyces mikatae. PLoS One 8:e62053
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Carrau, F., Boido, E., Dellacassa, E. (2015). Yeast Diversity and Flavor Compounds. In: Merillon, JM., Ramawat, K. (eds) Fungal Metabolites. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-19456-1_32-1
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Yeast Diversity and Flavor Compounds- Published:
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DOI: https://doi.org/10.1007/978-3-319-19456-1_32-2
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DOI: https://doi.org/10.1007/978-3-319-19456-1_32-1