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Congenital Tumors

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Keeling’s Fetal and Neonatal Pathology

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Abstract

Congenital tumors are rare and intriguing, and they are challenging, diagnostically, scientifically, therapeutically, and sometimes ethically. For many years, since at least when Willis wrote a book on the subject, there has been study of The Borderline of Embryology and Pathology. Congenital tumors certainly fit this space and this is reflected in their appearances and more in their molecular biology. They probably have a lot more to teach us.

There has not been the time for multiple mutations to develop as for adult tumors. These tumors are often genomically and chromosomally similar to the host, and morphologically they often appear to recapitulate differentiation. The genetic revolution has taken us further into understanding this close association, showing important pathways in cellular differentiation genes, imprinting, chromatin remodeling, and noncoding RNA. This may explain the issues related to whether these are tumors, or maldevelopment, or both sharing similar largely epigenetic pathways.

This chapter is a review of the major tumor types with some discussion of new entities and some of the pathogenetic factors. There are too many tumors and too many new discoveries to cover all the entities in detail, but this is to give a general guide to the topic.

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References

  1. Orbach D, Sarnacki S, Brisse HJ, Gauthier-Villars M, Jarreau PH, Tsatsaris V, et al. Neonatal cancer. Lancet Oncol. 2013;14:e609–20.

    PubMed  Google Scholar 

  2. Isaacs Jr H. Tumors of the fetus and infant. An atlas. New York: Springer; 2002.

    Google Scholar 

  3. Choudhary K, Panda S, Beena VT, Rajeev R, Sivakumar R, Krishanan S. Sialoblastoma: a literature review from 1966–2011. Natl J Maxillofac Surg. 2013;4:13–8.

    PubMed  PubMed Central  Google Scholar 

  4. Solis-Coria A, Vargas-Gonzalez R, Sotelo-Avila C. Rhabdomyomatous mesenchymal hamartoma presenting as a skin tag in the sternoclavicular area. Pathol Oncol Res. 2007;13:375–8.

    PubMed  Google Scholar 

  5. Alaggio R, Ninfo V, Rosolen A, Coffin CM. Primitive myxoid mesenchymal tumor of infancy: a clinicopathologic report of 6 cases. Am J Surg Pathol. 2006;30:388–94.

    PubMed  Google Scholar 

  6. Klimstra DS, Wenig BM, Adair CF, Heffess CS. Pancreatoblastoma. A clinicopathologic study and review of the literature. Am J Surg Pathol. 1995;19:1371–89.

    CAS  PubMed  Google Scholar 

  7. Isaacs HJ. Tumors of the fetus and newborn. Philadelphia: WB Saunders; 1997.

    Google Scholar 

  8. Campbell AN, Chan HS, O’Brien A, Smith CR, Becker LE. Malignant tumours in the neonate. Arch Dis Child. 1987;62:19–23.

    PubMed  PubMed Central  Google Scholar 

  9. Greaves M. In utero origins of childhood leukaemia. Early Hum Dev. 2005;81:123–9.

    PubMed  Google Scholar 

  10. Kinsler VA, Birley J, Atherton DJ. Great Ormond Street Hospital for Children Registry for Congenital Melanocytic Naevi: prospective study 1988–2007. Part 1—epidemiology, phenotype and outcomes. Br J Dermatol. 2009;160:143–50.

    CAS  PubMed  Google Scholar 

  11. Lambie M, Nadler C, Glat P, Van Duzer S, Halligan G, Geller E. Infantile melanoma–a triple threat: diagnosis and management. Ann Plast Surg. 2011;67:85–9.

    CAS  PubMed  Google Scholar 

  12. Phadke PA, Rakheja D, Le LP, Selim MA, Kapur P, Davis A, et al. Proliferative nodules arising within congenital melanocytic nevi: a histologic, immunohistochemical, and molecular analyses of 43 cases. Am J Surg Pathol. 2011;35:656–69.

    PubMed  Google Scholar 

  13. Moore SW, Satge D, Sasco AJ, Zimmermann A, Plaschkes J. The epidemiology of neonatal tumours. Report of an international working group. Pediatr Surg Int. 2003;19:509–19.

    CAS  PubMed  Google Scholar 

  14. Werb P, Scurry J, Ostor A, Fortune D, Attwood H. Survey of congenital tumors in perinatal necropsies. Pathology. 1992;24:247–53.

    CAS  PubMed  Google Scholar 

  15. Parkes SE, Muir KR, Southern L, Cameron AH, Darbyshire PJ, Stevens MC. Neonatal tumours: a thirty-year population-based study. Med Pediatr Oncol. 1994;22:309–17.

    CAS  PubMed  Google Scholar 

  16. Bellacosa A. Developmental disease and cancer: biological and clinical overlaps. Am J Med Genet A. 2013;161A:2788–96.

    PubMed  Google Scholar 

  17. Dome J HV. Wilms tumor overview. GeneReviews [serial on the Internet]. 2013. Available from: www.ncbi.nlm.nih.gov/books/NBK1294/.

  18. Gamis AS, Smith FO. Transient myeloproliferative disorder in children with Down syndrome: clarity to this enigmatic disorder. Br J Haematol. 2012;159:277–87.

    PubMed  Google Scholar 

  19. Isaacs Jr H. Fetal and neonatal leukemia. J Pediatr Hematol Oncol. 2003;25:348–61.

    PubMed  Google Scholar 

  20. Rump P, Zeegers MP, van Essen AJ. Tumor risk in Beckwith-Wiedemann syndrome: a review and meta-analysis. Am J Med Genet A. 2005;136:95–104.

    CAS  PubMed  Google Scholar 

  21. Botto LD, Flood T, Little J, Fluchel MN, Krikov S, Feldkamp ML, et al. Cancer risk in children and adolescents with birth defects: a population-based cohort study. PLoS One. 2013;8:e69077.

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Merks JH, Ozgen HM, Koster J, Zwinderman AH, Caron HN, Hennekam RC. Prevalence and patterns of morphological abnormalities in patients with childhood cancer. JAMA. 2008;299:61–9.

    CAS  PubMed  Google Scholar 

  23. Anonymous. Online Mendelian Inheritance in Man. Johns Hopkins University. 2015. Available from: http://www.omim.org/entry/194072.

  24. Anonymous. Mosaic variegated aneuploidy syndrome 1; MVA1. Online Mendelian Inheritance in Man. Johns Hopkins University. 2015. Available from: http://www.omim.org/entry/257300.

  25. Narod SA, Hawkins MM, Robertson CM, Stiller CA. Congenital anomalies and childhood cancer in Great Britain. Am J Hum Genet. 1997;60:474–85.

    CAS  PubMed  PubMed Central  Google Scholar 

  26. Inskip PD, Harvey EB, Boice Jr JD, Stone BJ, Matanoski G, Flannery JT, et al. Incidence of childhood cancer in twins. Cancer Causes Control. 1991;2:315–24.

    CAS  PubMed  Google Scholar 

  27. Bolande R. Prenatal exposures and childhood cancer. Pediatr Dev Pathol. 1999;2:208–14.

    CAS  PubMed  Google Scholar 

  28. Arnon J, Meirow D, Lewis-Roness H, Ornoy A. Genetic and teratogenic effects of cancer treatments on gametes and embryos. Hum Reprod Update. 2001;7:394–403.

    CAS  PubMed  Google Scholar 

  29. Einhorn L. Are there factors preventing cancer development during embryonic life? Oncodev Biol Med. 1983;4:219–29.

    CAS  PubMed  Google Scholar 

  30. Gwyn K. Children exposed to chemotherapy in utero. J Natl Cancer Inst Monogr. 2005;34:69–71.

    CAS  Google Scholar 

  31. Berry C. Congenital malformations. In: Berry C, editor. Paediatric pathology. Berlin: Springer; 1996. p. 43–62.

    Google Scholar 

  32. Miller R. Environmental causes of cancer in childhood. Adv Pediatr. 1978;25:97–119.

    CAS  PubMed  Google Scholar 

  33. Perera F. Molecular epidemiology: on the path to prevention? J Natl Cancer Inst Monogr. 2000;92:602–12.

    CAS  Google Scholar 

  34. Bove KE, Bhathena D, Wyatt RJ, Lucas BA, Holland NH. Diffuse metanephric adenoma after in utero aspirin intoxication. A unique case of progressive renal failure. Arch Pathol Lab Med. 1979;103:187–90.

    CAS  PubMed  Google Scholar 

  35. Tuman KJ, Chilcote R, Berkow RI, Moohr JW. Mesothelioma in child with prenatal exposure to isoniazid. Lancet. 1980;2:362.

    CAS  PubMed  Google Scholar 

  36. Allen Jr RW, Ogden B, Bentley FL, Jung AL. Fetal hydantoin syndrome, neuroblastoma, and hemorrhagic disease in a neonate. JAMA. 1980;244:1464–5.

    PubMed  Google Scholar 

  37. Baptista T, Araujo H, Rada P, Hernandez L. Congenital neuroblastoma in a boy born to a woman with bipolar disorder treated with carbamazepine during pregnancy. Prog Neuropsychopharmacol Biol Psychiatry. 1998;22:445–54.

    CAS  PubMed  Google Scholar 

  38. Buckley J. The aetiology of cancer in the very young. Br J Cancer. 1992;66:S8–12.

    Google Scholar 

  39. Borkhardt A, Wilda M, Fuchs U, Gortner L, Reiss I. Congenital leukaemia after heavy abuse of permethrin during pregnancy. Arch Dis Child Fetal Neonatal Ed. 2003;88:F436–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  40. Slater ME, Linabery AM, Spector LG, Johnson KJ, Hilden JM, Heerema NA, et al. Maternal exposure to household chemicals and risk of infant leukemia: a report from the children’s oncology group. Cancer Causes Control. 2011;22:1197–204.

    PubMed  PubMed Central  Google Scholar 

  41. Harvey EB, Boice JJ, Honeyman M, Flannery JT. Prenatal x-ray exposure and childhood cancer in twins. N Engl J Med. 1985;312:541–5.

    CAS  PubMed  Google Scholar 

  42. Doll R, Wakeford R. Risk of childhood cancer from fetal irradiation. Br J Radiol. 1997;70:130–9.

    CAS  PubMed  Google Scholar 

  43. Williams E. Radiation-induced thyroid cancer. Histopathology. 1993;23:387–9.

    CAS  PubMed  Google Scholar 

  44. Bounacer A, Wicker R, Caillou B, et al. High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation. Oncogene. 1997;15:1263–73.

    CAS  PubMed  Google Scholar 

  45. Draper G, Vincent T, Kroll ME, Swanson J. Childhood cancer in relation to distance from high voltage power lines in England and Wales: a case-control study. Br Med J. 2005;330:1290.

    Google Scholar 

  46. Greaves M. Infection, immune responses and the aetiology of childhood leukaemia. Nat Rev Cancer. 2006;6:193–203.

    CAS  PubMed  Google Scholar 

  47. Shiota K, Yamada S. Assisted reproductive technologies and birth defects. Congenit Anom (Kyoto). 2005;45:39–43.

    Google Scholar 

  48. Skakkebaek NE, Rajpert-De Meyts E, Main KM. Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod. 2001;16:972–8.

    CAS  PubMed  Google Scholar 

  49. Thompson JR, Gerald P, Willoughby ML, Armstrong BK. Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case-control study. Lancet. 2001;358:1935–40.

    CAS  PubMed  Google Scholar 

  50. Knudson AJ. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A. 1971;68:820–3.

    PubMed  PubMed Central  Google Scholar 

  51. Knudson Jr AG, Meadows A. Developmental genetics of neuroblastoma. J Natl Cancer Inst. 1976;57:675–82.

    PubMed  Google Scholar 

  52. Knudson Jr AG, Strong L. Mutation and cancer: a model for Wilms’ tumor of the kidney. J Natl Cancer Inst. 1972;48:313–24.

    PubMed  Google Scholar 

  53. Lee RS, Stewart C, Carter SL, Ambrogio L, Cibulskis K, Sougnez C, et al. A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers. J Clin Invest. 2012;122:2983–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  54. Grosfeld JL, Ballantine T, Lowe D, Baehner RL. Benign and malignant teratomas in children: analysis of 85 patients. Surgery. 1976;80:297–305.

    CAS  PubMed  Google Scholar 

  55. Marsden HB, Birch J, Swindell R. Germ cell tumours of childhood: a review of 137 cases. J Clin Pathol. 1981;34:879–83.

    CAS  PubMed  PubMed Central  Google Scholar 

  56. Tapper D, Lack E. Teratomas in infancy and childhood. A 54-year experience at the Children’s Hospital Medical Center. Ann Surg. 1983;198:398–410.

    CAS  PubMed  PubMed Central  Google Scholar 

  57. Lack E. Extragonadal germ cell tumors of the head and neck region: review of 16 cases. Hum Pathol. 1985;16:56–64.

    CAS  PubMed  Google Scholar 

  58. Perlman EJ, Kretschmar C. Pediatric germ cell tumors. Cancer Treat Res. 1997;92:163–200.

    CAS  PubMed  Google Scholar 

  59. Gonzalez-Crussi F. Extragonadal teratomas, Atlas of tumor pathology, vol. 2. Bethesda: Armed Forces Institute of Pathology; 1982. p. 50–76.

    Google Scholar 

  60. Mosbech CH, Rechnitzer C, Brok JS, Rajpert-De Meyts E, Hoei-Hansen CE. Recent advances in understanding the etiology and pathogenesis of pediatric germ cell tumors. J Pediatr Hematol Oncol. 2014;36:263–70.

    CAS  PubMed  Google Scholar 

  61. Du Plessis JP, Winship W, Kirstein JD. Fetus in fetu and teratoma. A case report and review. S Afr Med J. 1974;48:2119–22.

    PubMed  Google Scholar 

  62. Naudin ten Cate L, Vermeij-Keers C, Smit DA, Cohen-Overbeek TE, Gerssen-Schoorl KB, Dijkhuizen T. Intracranial teratoma with multiple fetuses: pre- and post-natal appearance. Hum Pathol. 1995;26:804–7.

    CAS  PubMed  Google Scholar 

  63. Isaacs Jr H. Perinatal (fetal and neonatal) germ cell tumors. J Pediatr Surg. 2004;39:1003–13.

    PubMed  Google Scholar 

  64. Noseworthy J, Lack E, Kozakewich HP, Vawter GF, Welch KJ. Sacrococcygeal germ cell tumors in childhood: an updated experience with 118 patients. J Pediatr Surg. 1981;16:358–64.

    CAS  PubMed  Google Scholar 

  65. Bale PM. Sacrococcygeal developmental abnormalities and tumors in children. Perspect Pediatr Pathol. 1984;8:9–56.

    CAS  PubMed  Google Scholar 

  66. Perlman E. Germ cell tumors. In: Stocker JT, Askin F, editors. Pathology of solid tumors in children. London: Chapman & Hall; 1998. p. 213–34.

    Google Scholar 

  67. Sebire NJ, Fowler D, Ramsay AD. Sacrococcygeal tumors in infancy and childhood; a retrospective histopathological review of 85 cases. Fetal Pediatr Pathol. 2004;23:295–303.

    CAS  PubMed  Google Scholar 

  68. Lemire RJ, Beckwith JB. Pathogenesis of congenital tumors and malformations of the sacrococcygeal region. Teratology. 1982;25:201–13.

    CAS  PubMed  Google Scholar 

  69. Anonymous. Currarino syndrome. Online Mendelian Inheritance in Man. Johns Hopkins University. 2015. Available from: http://www.omim.org/entry/176450.

  70. Heerema-McKenney A, Harrison MR, Bratton B, Farrell J, Zaloudek C. Congenital teratoma: a clinicopathologic study of 22 fetal and neonatal tumors. Am J Surg Pathol. 2005;29:29–38.

    PubMed  Google Scholar 

  71. Storr U, Rupprecht T, Bornemann A, et al. Congenital intracerebral teratoma: a rare differential diagnosis in newborn hydrocephalus. Pediatr Radiol. 1997;27:262–4.

    CAS  PubMed  Google Scholar 

  72. Heerema-McKenney A, Bowen J, Hill DA, Suster S, Qualman SJ, Members of Cancer Committee, College of American Pathologists. Protocol for the examination of specimens from pediatric and adult patients with extragonadal germ cell tumors. Arch Pathol Lab Med. 2011;135:630–9.

    PubMed  Google Scholar 

  73. Graf JL, Housely H, Albanese CT, Adzick NS, Harrison MR. A surprising histological evolution of preterm sacrococcygeal teratoma. J Pediatr Surg. 1998;33:177–9.

    CAS  PubMed  Google Scholar 

  74. Hawkins E, Issacs H, Cushing B, Rogers P. Occult malignancy in neonatal sacrococcygeal teratomas. A report from a combined pediatric oncology group and children’s cancer group study. Am J Pediatr Hematol Oncol. 1993;15:406–9.

    CAS  PubMed  Google Scholar 

  75. Gilcrease MZ, Brandt M, Hawkins EP. Yolk sac tumor identified at autopsy after surgical excision of immature sacrococcygeal teratoma. J Pediatr Surg. 1995;30:875–7.

    CAS  PubMed  Google Scholar 

  76. McKenney JK, Heerema-McKenney A, Rouse RV. Extragonadal germ cell tumors: a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations. Adv Anat Pathol. 2007;14:69–92.

    PubMed  Google Scholar 

  77. Olivares-Pakzad BA, Tazelaar H, Dehner LP, Kasperbauer JL, Bite U. Oropharyngeal hairy polyp with meningothelial elements. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995;79:462–8.

    CAS  PubMed  Google Scholar 

  78. Baumann FR, Nerlich A. Metastasizing cervical teratoma of the fetus. Pediatr Pathol. 1993;13:21–7.

    CAS  PubMed  Google Scholar 

  79. Dehner LP, Mills A, Talerman A, Billman GF, Krous HF, Platz CE. Germ cell neoplasms of head and neck soft tissues: a pathologic spectrum of teratomatous and endodermal sinus tumors. Hum Pathol. 1990;21:309–18.

    CAS  PubMed  Google Scholar 

  80. Kharga B, Kumar V, Prabhu PS, Sundeep PT, John SK. Neonatal gastric teratoma: a rare entity. J Clin Diagn Res. 2014;8:185–6.

    PubMed  PubMed Central  Google Scholar 

  81. Jenderny J, Köster E, Borchers O, et al. Interphase cytogenetics on paraffin sections of paediatric extragonadal yolk sac tumours. Virchows Arch. 1996;428:53–7.

    CAS  PubMed  Google Scholar 

  82. Sridhar S, Al-Moallem B, Kamal H, Terrile M, Stallings RL. New insights into the genetics of neuroblastoma. Mol Diagn Ther. 2013;17:63–9.

    CAS  PubMed  Google Scholar 

  83. Wieberdink J. Metastasis in neonatal neuroblastoma. In: Pochedly C, editor. Neuroblastoma, clinical and biological manifestations. New York: Elsevier; 1982. p. 13–21.

    Google Scholar 

  84. Chen CP, Chen S, Chuang CY, et al. Clinical and perinatal sonographic features of congenital adrenal cystic neuroblastoma: a case report with review of the literature. Ultrasound Obstet Gynecol. 1997;10:68–73.

    CAS  PubMed  Google Scholar 

  85. Kozakewich HP, Perez-Atayde A, Donovan MJ, et al. Cystic neuroblastoma: emphasis on gene expression, morphology, and pathogenesis. Pediatr Dev Pathol. 1998;1:17–28.

    CAS  PubMed  Google Scholar 

  86. Huff D. Diffuse, multicentric neurogenic tumors in two macerated fetuses: a possible intrauterine form of neurofibromatosis. Pediatr Pathol. 1985;4:125–36.

    CAS  PubMed  Google Scholar 

  87. Langlois NE, Gray E. Scatterbrain fetus. J Pathol. 1992;168:347–8.

    CAS  PubMed  Google Scholar 

  88. Beckwith JB, Martin RF. Observations on the histopathology of neuroblastomas. J Pediatr Surg. 1968;3:106–10.

    CAS  PubMed  Google Scholar 

  89. Shimada H, Chatten J, Newton Jr WA, Sachs N, Hamoudi AB, Chiba T, et al. Histopathologic prognostic factors in neuroblastic tumors: definition of subtypes of ganglioneuroblastoma and an age-linked classification of neuroblastomas. J Natl Cancer Inst. 1984;73:405–16.

    CAS  PubMed  Google Scholar 

  90. Shimada H, Umehara S, Monobe Y, Hachitanda Y, Nakagawa A, Goto S, et al. International neuroblastoma pathology classification for prognostic evaluation of patients with peripheral neuroblastic tumors: a report from the Children’s Cancer Group. Cancer. 2001;92:2451–61.

    CAS  PubMed  Google Scholar 

  91. Schonherr C, Ruuth K, Kamaraj S, Wang CL, Yang HL, Combaret V, et al. Anaplastic lymphoma kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells. Oncogene. 2012;31:5193–200.

    CAS  PubMed  Google Scholar 

  92. Ambros IM, Brunner C, Abbasi R, Frech C, Ambros PF. Ultra-high density SNP array in neuroblastoma molecular diagnostics. Front Oncol. 2014;4:202.

    PubMed  PubMed Central  Google Scholar 

  93. Joshi VV. Peripheral neuroblastic tumors: pathologic classification based on recommendations of international neuroblastoma pathology committee (modification of Shimada classification). Pediatr Dev Pathol. 2000;3:184–99.

    CAS  PubMed  Google Scholar 

  94. Stephenson SR, Cook B, Mease AD, Ruymann FB. The prognostic significance of age and pattern of metastases in stage IV-S neuroblastoma. Cancer. 1986;58:372–5.

    CAS  PubMed  Google Scholar 

  95. Hiyama E, Hiyama K, Yokoyama T, Matsuura Y, Piatyszek MA, Shay JW. Correlating telomerase activity levels with human neuroblastoma outcomes. Nat Med. 1995;1:249–55.

    CAS  PubMed  Google Scholar 

  96. Kerbl R, Urban C, Lackner H, et al. Connatal localized neuroblastoma. The case to delay treatment. Cancer. 1996;77:1395–401.

    CAS  PubMed  Google Scholar 

  97. Fritsch P, Kerbl R, Lackner H. Urban C “Wait and see” strategy in localized neuroblastoma in infants: an option not only for cases detected by mass screening. Pediatr Blood Cancer. 2004;43:679–82.

    PubMed  Google Scholar 

  98. Craft AW, Parker L. Poor prognosis neuroblastoma: is screening the answer? Br J Cancer. 1992;18:S96–101.

    CAS  Google Scholar 

  99. Kawakami T, Monobe Y, Monforte H, et al. Pathology review of screening negative neuroblastomas: a report from the Quebec Neuroblastoma Screening Project. Cancer. 1998;83:575–81.

    CAS  PubMed  Google Scholar 

  100. Brown P. Treatment of infant leukemias: challenge and promise. Hematol Am Soc Hematol Educ Program. 2013;2013:596–600.

    PubMed  Google Scholar 

  101. Bresters D, Reus A, Veerman AJ, van Wering ER, van der Does-van den Berg A, Kaspers GJ. Congenital leukaemia: the Dutch experience and review of the literature. Br J Haematol. 2002;117:513–24.

    PubMed  Google Scholar 

  102. Zipursky A. Transient leukaemia—a benign form of leukaemia in newborn infants with trisomy 21. Br J Haematol. 2003;120:930–8.

    PubMed  Google Scholar 

  103. Silvio F, Carlo L, Elena B, Nicoletta B, Daniela F, Roberto M. Transient abnormal myelopoiesis in Noonan syndrome. J Pediatr Hematol Oncol. 2002;24:763–4.

    PubMed  Google Scholar 

  104. Weitzman S, Jaffe R. Uncommon histiocytic disorders: the non-Langerhans cell histiocytoses. Pediatr Blood Cancer. 2005;45:256–64.

    PubMed  Google Scholar 

  105. Black J, Coffin CM, Dehner LP. Fibrohistiocytic tumors and related neoplasms in children and adolescents. Pediatr Dev Pathol. 2012;15:181–210.

    PubMed  Google Scholar 

  106. Isaacs Jr H. Fetal and neonatal histiocytoses. Pediatr Blood Cancer. 2006;47:123–9.

    PubMed  Google Scholar 

  107. Foucar E, Rosai J, Dorfman R. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): review of the entity. Semin Diagn Pathol. 1990;7:19–73.

    CAS  PubMed  Google Scholar 

  108. Chan JK, Lamant L, Algar E, Delsol G, Tsang WY, Lee KC, et al. ALK+ histiocytosis: a novel type of systemic histiocytic proliferative disorder of early infancy. Blood. 2008;112:2965–8.

    CAS  PubMed  Google Scholar 

  109. Minkov M, Prosch H, Steiner M, et al. Langerhans cell histiocytosis in neonates. Pediatr Blood Cancer. 2005;45:802–7.

    CAS  PubMed  Google Scholar 

  110. Willman C. Detection of clonal histiocytes in Langerhans cell histiocytosis: biology and clinical significance. Br J Cancer. 1994;23:S29–33.

    CAS  Google Scholar 

  111. Sheils C, Dover G. Frequency of congenital anomalies in patients with histiocytosis x. Am J Hematol. 1989;31:91–5.

    CAS  PubMed  Google Scholar 

  112. Egeler RM, Neglia J, Puccetti DM, Brennan CA, Nesbit ME. Association of Langerhans cell histiocytosis with malignant neoplasms. Cancer. 1993;71:865–73.

    CAS  PubMed  Google Scholar 

  113. Feldman AL, Berthold F, Arceci RJ, et al. Clonal relationship between precursor t-lymphoblastic leukaemia/lymphoma and langerhans-cell histiocytosis. Lancet Oncol. 2005;6:435–7.

    PubMed  Google Scholar 

  114. Risma K, Jordan MB. Hemophagocytic lymphohistiocytosis: updates and evolving concepts. Curr Opin Pediatr. 2012;24:9–15.

    CAS  PubMed  Google Scholar 

  115. Sullivan KE, Delaat C, Douglas SD, Filipovich AH. Defective natural killer cell function in patients with hemophagocytic lymphohistiocytosis and in first degree relatives. Pediatr Res. 1998;44:465–8.

    CAS  PubMed  Google Scholar 

  116. Goransdotter Ericson K, Fadeel B, Nilsson-Ardnor S, et al. Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis. Am J Hum Genet. 2001;68:590–7.

    CAS  PubMed  PubMed Central  Google Scholar 

  117. Feldmann J, Callebaut I, Raposo G, et al. Munc13–4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3). Cell. 2003;115:461–73.

    CAS  PubMed  Google Scholar 

  118. Ishii E, Ueda I, Shirakawa R, et al. Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions. Blood. 2005;105:3442–8.

    CAS  PubMed  Google Scholar 

  119. Henter J. Biology and treatment of familial hemophagocytic lymphohistiocytosis: importance of perforin in lymphocyte-mediated cytotoxicity and triggering of apoptosis. Med Pediatr Oncol. 2002;38:305–9.

    PubMed  Google Scholar 

  120. Janka GE, Schneider E. Modern management of children with haemophagocytic lymphohistiocytosis. Br J Haematol. 2004;124:4–14.

    PubMed  Google Scholar 

  121. Horne A, Janka G, Maarten Egeler R, et al. Haematopoietic stem cell transplantation in haemophagocytic lymphohistiocytosis. Br J Haematol. 2005;129:622–30.

    PubMed  Google Scholar 

  122. Zvulunov A, Barak Y, Metzker A. Juvenile xanthogranuloma, neurofibromatosis, and juvenile chronic myelogenous leukemia. World Stat Anal Arch Dermatol. 1995;131:904–8.

    CAS  Google Scholar 

  123. Janssen D, Harms D. Juvenile xanthogranuloma in childhood and adolescence: a clinicopathologic study of 129 patients from the Kiel pediatric tumor registry. Am J Surg Pathol. 2005;29:21–8.

    PubMed  Google Scholar 

  124. Dehner L. Juvenile xanthogranulomas in the first two decades of life: a clinicopathologic study of 174 cases with cutaneous and extracutaneous manifestations. Am J Surg Pathol. 2003;27:579–93.

    PubMed  Google Scholar 

  125. Freyer DR, Kennedy R, Bostrom BC, Kohut G, Dehner LP. Juvenile xanthogranuloma: forms of systemic disease and their clinical implications. J Pediatr. 1996;129:227–37.

    CAS  PubMed  Google Scholar 

  126. Kauffman SL, Stout A. Congenital mesenchymal tumors. Cancer. 1965;18:460–76.

    CAS  PubMed  Google Scholar 

  127. Fletcher CDM, Bridge JA, Hogendoorn P, Mertens F. WHO classification of tumours of soft tissue and bone. 4th ed. Lyon: IARC; 2013.

    Google Scholar 

  128. Bruder E, Alaggio R, Kozakewich HP, Jundt G, Dehner LP, Coffin CM. Vascular and perivascular lesions of skin and soft tissues in children and adolescents. Pediatr Dev Pathol. 2012;15:26–61.

    PubMed  Google Scholar 

  129. Anonymous. Myofibromatosis, infantile, 1; IMF1. Online Mendelian Inheritance in Man. Johns Hopkins University. 2015. Available from: http://www.omim.org/entry/228550.

  130. Jennings TA, Duray P, Collins FS, Sabetta J, Enzinger FM. Infantile myofibromatosis. Evidence for an autosomal-dominant disorder. Am J Surg Pathol. 1984;8:529–38.

    CAS  PubMed  Google Scholar 

  131. Zand DJ, Huff D, Everman D, et al. Autosomal dominant inheritance of infantile myofibromatosis. Am J Med Genet A. 2004;126:261–6.

    Google Scholar 

  132. Oudijk L, den Bakker MA, Hop WC, Cohen M, Charles AK, Alaggio R, et al. Solitary, multifocal and generalized myofibromas: clinicopathological and immunohistochemical features of 114 cases. Histopathology. 2012;60:E1–11.

    PubMed  Google Scholar 

  133. Coffin CM, Neilson KA, Ingels S, Frank-Gerszberg R, Dehner LP. Congenital generalized myofibromatosis: a disseminated angiocentric myofibromatosis. Pediatr Pathol Lab Med. 1995;15:571–87.

    CAS  PubMed  Google Scholar 

  134. Wright C, Corbally M, Hayes R, McDermott MB. Multifocal infantile myofibromatosis and generalized fibromuscular dysplasia in a child: evidence for a common pathologic process? Pediatr Dev Pathol. 2004;7:385–930.

    PubMed  Google Scholar 

  135. Dormans JP, Spiegel D, Meyer J, et al. Fibromatoses in childhood: the desmoid/fibromatosis complex. Med Pediatr Oncol. 2001;37:126–31.

    CAS  PubMed  Google Scholar 

  136. Cates JM, Stricker TP, Sturgeon D, Coffin CM. Desmoid-type fibromatosis-associated Gardner fibromas: prevalence and impact on local recurrence. Cancer Lett. 2014;353:176–81.

    CAS  PubMed  Google Scholar 

  137. Wang WL, Nero C, Pappo A, Lev D, Lazar AJ, Lopez-Terrada D. CTNNB1 genotyping and APC screening in pediatric desmoid tumors: a proposed algorithm. Pediatr Dev Pathol. 2012;15:361–7.

    CAS  PubMed  Google Scholar 

  138. Cheng JC, Tang S, Chen TM. Sternocleidomastoid pseudotumor and congenital muscular torticollis in infants: a prospective study of 510 cases. J Pediatr. 1999;134:712–6.

    CAS  PubMed  Google Scholar 

  139. Reye RD. Recurring digital fibrous tumors of childhood. Arch Pathol. 1965;80:228–31.

    CAS  PubMed  Google Scholar 

  140. Purdy LJ, Colby T. Infantile digital fibromatosis occurring outside the digit. Am J Surg Pathol. 1984;8:787–90.

    CAS  PubMed  Google Scholar 

  141. Viale G, Doglioni C, Iuzzolino P, et al. Infantile digital fibromatosis-like tumour (inclusion body fibromatosis) of adulthood: report of two cases with ultrastructural and immunocytochemical findings. Histopathology. 1988;12:415–24.

    CAS  PubMed  Google Scholar 

  142. Pettinato G, Manivel J, d’Amore ES, Jaszcz W, Gorlin RJ. Melanotic neuroectodermal tumor of infancy. A reexamination of a histogenetic problem based on immunohistochemical, flow cytometric, and ultrastructural study of 10 cases. Am J Surg Pathol. 1991;15:233–45.

    CAS  PubMed  Google Scholar 

  143. Sebire NJ, Ramsay A, Sheppard M, Malone M, Harding B, Risdon RA. Intravascular inflammatory myofibroblastic tumors in infancy. Pediatr Dev Pathol. 2002;5:400–4.

    PubMed  Google Scholar 

  144. Harvell JD, Kilpatrick S, White WL. Histogenetic relations between giant cell fibroblastoma and dermatofibrosarcoma protuberans. CD34 staining showing the spectrum and a simulator. Am J Dermatopathol. 1998;20:339–45.

    CAS  PubMed  Google Scholar 

  145. Terrier-Lacombe MJ, Guillou L, et al. Dermatofibrosarcoma protuberans, giant cell fibroblastoma, and hybrid lesions in children: clinicopathologic comparative analysis of 28 cases with molecular data–a study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol. 2003;27:27–39.

    PubMed  Google Scholar 

  146. Gu W, Ogose A, Kawashima H, et al. Congenital dermatofibrosarcoma protuberans with fibrosarcomatous and myxoid change. J Clin Pathol. 2005;58:984–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  147. Chung EB, Enzinger F. Infantile fibrosarcoma. Cancer. 1976;38:729–39.

    CAS  PubMed  Google Scholar 

  148. Knezevich SR, Garnett M, Pysher TJ, Beckwith JB, Grundy PE, Sorensen PH. ETV6–NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. Cancer Res. 1998;58:5046–8.

    CAS  PubMed  Google Scholar 

  149. Knezevich SR, McFadden D, Tao W, Lim JF, Sorensen PH. A novel ETV6–NTRK3 gene fusion in congenital fibrosarcoma. Nat Genet. 1998;18:184–7.

    CAS  PubMed  Google Scholar 

  150. Rubin BP, Chen C, Morgan TW, et al. Congenital mesoblastic nephroma t(12;15) is associated with etv6–NTRK3 gene fusion: cytogenetic and molecular relationship to congenital (infantile) fibrosarcoma. Am J Pathol. 1998;153:1451–8.

    CAS  PubMed  PubMed Central  Google Scholar 

  151. Neifeld JP, Berg J, Godwin D, Saizberg AM. A retrospective epidemiologic study of pediatric fibrosarcomas. J Pediatr Surg. 1978;13:735–9.

    CAS  PubMed  Google Scholar 

  152. Nonaka D, Sun C. Congenital fibrosarcoma with metastasis in a fetus. Pediatr Dev Pathol. 2004;7:187–91.

    PubMed  Google Scholar 

  153. Salloum E, Caillaud J, Flamant F, Landman J, Lemerle J. Poor prognosis infantile fibrosarcoma with pathologic features of malignant fibrous histiocytoma after local recurrence. Med Pediatr Oncol. 1990;18:295–8.

    CAS  PubMed  Google Scholar 

  154. Dickey GE, Sotelo-Avila C. Fibrous hamartoma of infancy: current review. Pediatr Dev Pathol. 1999;2:236–43.

    CAS  PubMed  Google Scholar 

  155. Saab ST, McClain CM, Coffin CM. Fibrous hamartoma of infancy: a clinicopathologic analysis of 60 cases. Am J Surg Pathol. 2014;38:394–401.

    PubMed  Google Scholar 

  156. Sotelo-Avila C, Bale PM. Subdermal fibrous hamartoma of infancy: pathology of 40 cases and differential diagnosis. Pediatr Pathol. 1994;14:39–52.

    CAS  PubMed  Google Scholar 

  157. Lakshminarayanan R, Konia T, Welborn J. Fibrous hamartoma of infancy: a case report with associated cytogenetic findings. Arch Pathol Lab Med. 2005;129:520–2.

    PubMed  Google Scholar 

  158. Enzinger FM, Zhang R. Plexiform fibrohistiocytic tumor presenting in children and young adults. An analysis of 65 cases. Am J Surg Pathol. 1988;12:818–26.

    CAS  PubMed  Google Scholar 

  159. Remstein ED, Arndt C, Nascimento AG. Plexiform fibrohistiocytic tumor: clinicopathologic analysis of 22 cases. Am J Surg Pathol. 1999;23:662–70.

    CAS  PubMed  Google Scholar 

  160. Leclerc S, Hamel-Teillac D, Oger P, Brousse N, Fraitag S. Plexiform fibrohistiocytic tumor: three unusual cases occurring in infancy. J Cutan Pathol. 2005;32:572–6.

    PubMed  Google Scholar 

  161. Fetsch JF, Miettinen M, Laskin WB, Michal M, Enzinger FM. A clinicopathologic study of 45 pediatric soft tissue tumors with an admixture of adipose tissue and fibroblastic elements, and a proposal for classification as lipofibromatosis. Am J Surg Pathol. 2000;24:1491–500.

    CAS  PubMed  Google Scholar 

  162. Ortega-Monzo C, Molina-Gallardo I, Monteagudo-Castro C, et al. Precalcaneal congenital fibrolipomatous hamartoma: a report of four cases. Pediatr Dermatol. 2000;17:429–31.

    CAS  PubMed  Google Scholar 

  163. Landing BH, Nadorra R. Infantile systemic hyalinosis: report of four cases of a disease, fatal in infancy, apparently different from juvenile systemic hyalinosis. Pediatr Pathol Lab Med. 1986;6:55–79.

    CAS  Google Scholar 

  164. Glover MT, Lake B, Atherton DJ. Infantile systemic hyalinosis: newly recognized disorder of collagen? Pediatrics. 1991;87:228–34.

    CAS  PubMed  Google Scholar 

  165. Senzaki H, Kiyozuka Y, Uemura Y, Shikata N, Ueda S, Tsubura A. Juvenile hyaline fibromatosis: a report of two unrelated adult sibling cases and a literature review. Pathol Int. 1998;48:230–6.

    CAS  PubMed  Google Scholar 

  166. Urbina F, Sazunic I, Murray G. Infantile systemic hyalinosis or juvenile hyaline fibromatosis? Pediatr Dermatol. 2004;21:154–9.

    PubMed  Google Scholar 

  167. Isaacs Jr H. Fetal and neonatal rhabdoid tumor. J Pediatr Surg. 2010;45:619–26.

    PubMed  Google Scholar 

  168. Brennan B, Stiller C, Bourdeaut F. Extracranial rhabdoid tumours: what we have learned so far and future directions. Lancet Oncol. 2013;14:e329–36.

    PubMed  Google Scholar 

  169. Lobe TE, Wiener E, Hays DM, et al. Neonatal rhabdomyosarcoma: the IRS experience. J Pediatr Surg. 1994;29:1167–70.

    CAS  PubMed  Google Scholar 

  170. Anderson JR, Barr FG, Hawkins DS, Parham DM, Skapek SX, Triche TJ. Fusion-negative alveolar rhabdomyosarcoma: modification of risk stratification is premature. J Clin Oncol. 2010;28:e587–8; author reply e589–90.

    PubMed  Google Scholar 

  171. Parham DM, Alaggio R, Coffin CM. Myogenic tumors in children and adolescents. Pediatr Dev Pathol. 2012;15:211–38.

    PubMed  Google Scholar 

  172. Lundgren L, Angervall L, Stenman G, Kindblom LG. Infantile rhabdomyofibrosarcoma: a high-grade sarcoma distinguishable from infantile fibrosarcoma and rhabdomyosarcoma. Hum Pathol. 1993;24:785–95.

    CAS  PubMed  Google Scholar 

  173. Anonymous. ISSVA classification for vascular anomalies. International Society for the Study of Vascular Anomalies. 2015. Approved at the 20th ISSVA Workshop, Melbourne, April 2014. Available from: issva.org/classification.

    Google Scholar 

  174. Chen TS, Eichenfield LF, Friedlander SF. Infantile hemangiomas: an update on pathogenesis and therapy. Pediatrics. 2013;131:99–108.

    PubMed  Google Scholar 

  175. Bakaris S, Karabiber H, Yuksel M, Parmaksiz G, Kiran H. Case of large placental chorioangioma associated with diffuse neonatal hemangiomatosis. Pediatr Dev Pathol. 2004;7:258–61.

    PubMed  Google Scholar 

  176. Johnson RE, Scheithauer B, Dahlin DC. Melanotic neuroectodermal tumor of infancy. A review of seven cases. Cancer. 1983;52:661–6.

    CAS  PubMed  Google Scholar 

  177. Coffin CM, Alaggio R. Adipose and myxoid tumors of childhood and adolescence. Pediatr Dev Pathol. 2012;15:239–54.

    PubMed  Google Scholar 

  178. McDermott MB, Ponder T, Dehner LP. Nasal chondromesenchymal hamartoma: an upper respiratory tract analogue of the chest wall mesenchymal hamartoma. Am J Surg Pathol. 1998;22:425–33.

    CAS  PubMed  Google Scholar 

  179. Qualman SJ, Bowen J, Amin MB, Srigley JR, Grundy PE, Perlman EJ. Protocol for the examination of specimens from patients with Wilms tumor (nephroblastoma) or other renal tumors of childhood. Arch Pathol Lab Med. 2003;127:1280–9.

    PubMed  Google Scholar 

  180. Marsden HB, Newton Jr W. New look at mesoblastic nephroma. J Clin Pathol. 1986;39:508–13.

    CAS  PubMed  PubMed Central  Google Scholar 

  181. Vujanic GM, Sandstedt B, Dijoud F, Harms D, Delemarre JF. Nephrogenic rest associated with a mesoblastic nephroma—what does it tell us? Pediatr Pathol Lab Med. 1995;15:469–75.

    CAS  PubMed  Google Scholar 

  182. Sutherland RW, Weiner J, Hicks MJ, Hawkins EP, Chintagumpala M. Congenital mesoblastic nephroma in a child with the Beckwith-Wiedemann syndrome. J Urol. 1997;158:1532–3.

    CAS  PubMed  Google Scholar 

  183. Gormley TS, Skoog S, Jones RV, Maybee D. Cellular congenital mesoblastic nephroma: what are the options. J Urol. 1989;142:479–83.

    CAS  PubMed  Google Scholar 

  184. Marsden HB, Lawler W. Primary renal tumours in the first year of life. A population based review. Virchows Arch A Pathol Anat Histopathol. 1983;399:1–9.

    CAS  PubMed  Google Scholar 

  185. Ritchey ML, Azizkhan R, Beckwith JB, Hrabovsky EE, Haase GM. Neonatal wilms’ tumor. J Pediatr Surg. 1995;30:856–9.

    CAS  PubMed  Google Scholar 

  186. Bove KE, McAdams A. The nephroblastomatosis complex and its relationship to Wilms’ tumor: a clinicopathologic treatise. Perspect Pediatr Pathol. 1976;3:185–223.

    CAS  PubMed  Google Scholar 

  187. Machin G. Persistent renal blastema (nephroblastomatosis) as a frequent precursor of Wilms’ tumor; a pathological and clinical review. Part 2. Significance of nephroblastomatosis in the genesis of Wilms’ tumor. Am J Pediatr Hematol Oncol. 1980;2:253–61.

    CAS  PubMed  Google Scholar 

  188. Beckwith JB, Kiviat NB, Bonadio JF. Nephrogenic rests, nephroblastomatosis, and the pathogenesis of Wilms’ tumor. Pediatr Pathol Affiliate Int Paediatr Pathol Assoc. 1990;10:1–36.

    CAS  Google Scholar 

  189. Mirkin LD, Azzarelli B, Seo IS. Extrarenal Wilms’ tumor with cerebellar metastasis in a four-year-old girl with spina bifida. Am J Clin Pathol. 1990;93:805–9.

    CAS  PubMed  Google Scholar 

  190. Kusafuka T, Miao J, Yoneda A, Kuroda S, Fukuzawa M. Novel germ-line deletion of SNF5/INI1/SMARCB1 gene in neonate presenting with congenital malignant rhabdoid tumor of kidney and brain primitive neuroectodermal tumor. Genes Chromosomes Cancer. 2004;40:133–9.

    CAS  PubMed  Google Scholar 

  191. Tekautz TM, Fuller C, Blaney S, et al. Atypical teratoid/rhabdoid tumors (ATRT): improved survival in children 3 years of age and older with radiation therapy and high-dose alkylator-based chemotherapy. J Clin Oncol. 2005;23:1491–9.

    CAS  PubMed  Google Scholar 

  192. Jerkins GR, Callihan T. Ossifying renal tumor of infancy. J Urol. 1986;135:120–1.

    CAS  PubMed  Google Scholar 

  193. Sotelo-Avila C, Beckwith J, Johnson JE. Ossifying renal tumor of infancy: a clinicopathologic study of nine cases. Pediatr Pathol Lab Med. 1995;15:745–62.

    CAS  PubMed  Google Scholar 

  194. Kataoka Y, Shimada H, Sugimoto T, et al. Congenital sarcoma in the terminal ileum histologically resembling clear cell sarcoma of the kidney: a case report with an immunohistochemical study. Hum Pathol. 1993;24:1026–30.

    CAS  PubMed  Google Scholar 

  195. Isaacs Jr H. Fetal and neonatal hepatic tumors. J Pediatr Surg. 2007;42:1797–803.

    PubMed  Google Scholar 

  196. Thompson PA, Chintagumpala M. Renal and hepatic tumors in the neonatal period. Semin Fetal Neonatal Med. 2012;17:216–21.

    PubMed  Google Scholar 

  197. Cross SS, Variend S. Combined hepatoblastoma and yolk sac tumor of the liver. Cancer. 1992;69:1323–6.

    CAS  PubMed  Google Scholar 

  198. Kim SN, Chi J, Kim YW, et al. Neonatal choriocarcinoma of liver. Pediatr Pathol. 1993;13:723–30.

    CAS  PubMed  Google Scholar 

  199. Weinberg AG, Finegold M. Primary hepatic tumors of childhood. Hum Pathol. 1983;14:512–37.

    CAS  PubMed  Google Scholar 

  200. Greer ML, Danin J, Lamont AC. Glomerulocystic disease with hepatoblastoma in a neonate: a case report. Pediatr Radiol. 1998;28:703–5.

    CAS  PubMed  Google Scholar 

  201. Ross JA, Gurney J. Hepatoblastoma incidence in the united states from 1973 to 1992. Med Pediatr Oncol. 1998;30:141–2.

    CAS  PubMed  Google Scholar 

  202. Tanimura M, Matsui I, Abe J, et al. Increased risk of hepatoblastoma among immature children with a lower birth weight. Cancer Res. 1998;58:3032–5.

    CAS  PubMed  Google Scholar 

  203. Lack EE, Neave C, Vawter GF. Hepatoblastoma. A clinical and pathologic study of 54 cases. Am J Surg Pathol. 1982;6:693–705.

    CAS  PubMed  Google Scholar 

  204. Teraguchi M, Nogi S, Ikemoto Y, et al. Multiple hepatoblastomas associated with trisomy 18 in a 3-year-old girl. Pediatr Hematol Oncol. 1997;14:463–7.

    CAS  PubMed  Google Scholar 

  205. Stocker JT, Ishak K. Mesenchymal hamartoma of the liver: report of 30 cases and review of the literature. Pediatr Pathol Lab Med. 1983;1:245–67.

    CAS  Google Scholar 

  206. Tovbin J, Segal M, Tavori I, Lotan G, Maymon R. Hepatic mesenchymal hamartoma: a pediatric tumor that may be diagnosed prenatally. Ultrasound Obstet Gynecol. 1997;10:63–5.

    CAS  PubMed  Google Scholar 

  207. Lennington WJ, Gray GJ, Page DL. Mesenchymal hamartoma of liver. A regional ischemic lesion of a sequestered lobe. Am J Dis Child. 1993;147:193–6.

    CAS  PubMed  Google Scholar 

  208. Kapur RP, Berry JE, Tsuchiya KD, Opheim KE. Activation of the chromosome 19q microRNA cluster in sporadic and androgenetic-biparental mosaicism-associated hepatic mesenchymal hamartoma. Pediatr Dev Pathol. 2014;17:75–84.

    PubMed  Google Scholar 

  209. Lauwers GY, Grant L, Donnelly WH, et al. Hepatic undifferentiated (embryonal) sarcoma arising in a mesenchymal hamartoma. Am J Surg Pathol. 1997;21:1248–54.

    CAS  PubMed  Google Scholar 

  210. Isaacs H. Fetal brain tumors: a review of 154 cases. Am J Perinatol. 2009;26:453–66.

    PubMed  Google Scholar 

  211. Isaacs Jr H. II. Perinatal brain tumors: a review of 250 cases. Pediatr Neurol. 2002;27:333–42.

    PubMed  Google Scholar 

  212. Isaacs Jr H. I. Perinatal brain tumors: a review of 250 cases. Pediatr Neurol. 2002;27:249–61.

    PubMed  Google Scholar 

  213. Di Rocco C, Iannelli A, Ceddia A. Intracranial tumors of the first year of life. A cooperative survey of the 1986–1987 Education Committee of the ISPN. Childs Nerv Syst. 1991;7:150–3.

    PubMed  Google Scholar 

  214. Di Rocco C, Ceddia A, Iannelli A. Intracranial tumours in the first year of life. A report on 51 cases. Acta Neurochir (Wien). 1993;123:14–24.

    Google Scholar 

  215. Buetow PC, Smirniotopoulos J, Done S. Congenital brain tumors: a review of 45 cases. Am J Roentgenol. 1990;155:587–93.

    CAS  Google Scholar 

  216. Raisanen JM, Davis R. Congenital brain tumors. Pathology (Phila). 1993;2:103–16.

    CAS  Google Scholar 

  217. de Kock L, Sabbaghian N, Plourde F, Srivastava A, Weber E, Bouron-Dal Soglio D, et al. Pituitary blastoma: a pathognomonic feature of germ-line DICER1 mutations. Acta Neuropathol. 2014;128:111–22.

    PubMed  PubMed Central  Google Scholar 

  218. Zimmerman MA, Goumnerova L, Proctor M, et al. Continuous remission of newly diagnosed and relapsed central nervous system atypical teratoid/rhabdoid tumor. J Neurooncol. 2005;72:77–84.

    PubMed  Google Scholar 

  219. De Munnynck K, Van Gool S, Van Calenbergh F, et al. Desmoplastic infantile ganglioglioma: a potentially malignant tumor? Am J Surg Pathol. 2002;26:1515–22.

    PubMed  Google Scholar 

  220. Ross JH, Rybicki L, Kay R. Clinical behavior and a contemporary management algorithm for prepubertal testis tumors: a summary of the prepubertal testis tumor registry. J Urol. 2002;168:1675–8; discussion 1678–9.

    PubMed  Google Scholar 

  221. Luisiri A, Vogler C, Steinhardt G, Silberstein M. Neonatal cystic testicular gonadoblastoma. Sonographic and pathologic findings. J Ultrasound Med. 1991;10:59–61.

    CAS  PubMed  Google Scholar 

  222. Hong JR, Barber M, Scott CI, Guttenberg M, Wolfson PJ. 3–year-old phenotypic female with campomelic dysplasia and bilateral gonadoblastoma. J Pediatr Surg. 1995;30:1735–7.

    CAS  PubMed  Google Scholar 

  223. Swerdlow AJ, English J, Qiao Z. The risk of melanoma in patients with congenital nevi: a cohort study. J Am Acad Dermatol. 1995;32:595–9.

    CAS  PubMed  Google Scholar 

  224. Hale EK, Stein J, Ben-Porat L, et al. Association of melanoma and neurocutaneous melanocytosis with large congenital melanocytic naevi—results from the NYU-LCMN registry. Br J Dermatol. 2005;152:512–7.

    CAS  PubMed  Google Scholar 

  225. Ka VS, Dusza S, Halpern AC, Marghoob AA. The association between large congenital melanocytic naevi and cutaneous melanoma: preliminary findings from an internet-based registry of 379 patients. Melanoma Res. 2005;15:61–7.

    PubMed  Google Scholar 

  226. Hill DA, Jarzembowski JA, Priest JR, Williams G, Schoettler P, Dehner LP. Type I pleuropulmonary blastoma: pathology and biology study of 51 cases from the international pleuropulmonary blastoma registry. Am J Surg Pathol. 2008;32:282–95.

    PubMed  Google Scholar 

  227. Foulkes WD, Priest JR, Duchaine TF. DICER1: mutations, microRNAs and mechanisms. Nat Rev Cancer. 2014;14:662–72.

    CAS  PubMed  Google Scholar 

  228. Dishop MK, McKay EM, Kreiger PA, Priest JR, Williams GM, Langston C, et al. Fetal lung interstitial tumor (FLIT): a proposed newly recognized lung tumor of infancy to be differentiated from cystic pleuropulmonary blastoma and other developmental pulmonary lesions. Am J Surg Pathol. 2010;34:1762–72.

    PubMed  Google Scholar 

  229. Potter JF, Schoeneman M. Metastasis of maternal cancer to the placenta and fetus. Cancer. 1970;25:380–8.

    CAS  PubMed  Google Scholar 

  230. Smith LH, Danielsen B, Allen ME, Cress R. Cancer associated with obstetric delivery: results of linkage with the California cancer registry. Am J Obstet Gynecol. 2003;183:1128–35.

    Google Scholar 

  231. Haas J. Pregnancy in association with a newly diagnosed cancer: a population-based epidemiologic assessment. Int J Cancer. 1984;34:229–35.

    CAS  PubMed  Google Scholar 

  232. Ackerman J, Gilbert-Barness E. Malignancy metastatic to the products of conception: a case report with literature review. Pediatr Pathol Lab Med. 1997;17:577–86.

    CAS  PubMed  Google Scholar 

  233. Fox H. Pathology of the placenta. 2nd ed. London: WB Saunders; 1997.

    Google Scholar 

  234. Benirschke K, Kaufmann P. Pathology of the human placenta. 4th ed. New York: Springer; 2000.

    Google Scholar 

  235. Baergen RN, Johnson D, Moore T, Benirschke K. Maternal melanoma metastatic to the placenta: a case report and review of the literature. Arch Pathol Lab Med. 1997;121:508–11.

    CAS  PubMed  Google Scholar 

  236. Rothman LA, Cohen C, Astarloa J. Placental and fetal involvement by maternal malignancy: a report of rectal carcinoma and review of the literature. Am J Obstet Gynecol. 1973;116:1023–34.

    CAS  PubMed  Google Scholar 

  237. Teksam M, McKinney A, Short J, Casey SO, Truwit CL. Intracranial metastasis via transplacental (vertical) transmission of maternal small cell lung cancer to fetus: CT and MRI findings. Acta Radiol. 2004;45:577–9.

    CAS  PubMed  Google Scholar 

  238. Walker JW, Reinisch J, Monforte HL. Maternal pulmonary adenocarcinoma metastatic to the fetus: first recorded case report and literature review. Pediatr Pathol Mol Med. 2002;21:57–69.

    PubMed  Google Scholar 

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  1. Department of Pathology, Sidra Medical and Research Center & Weill Cornell Medical College in Qatar, Doha, Qatar

    Adrian K. Charles MD (Cantab)

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  1. Department of Pathology Department of Obstetrics and Gynaecology, University of Adelaide, North Adelaide, South Australia, Australia

    T. Yee Khong

  2. Department of Histopathology, Women’s & Children’s Hospital, North Adelaide, South Australia, Australia

    T. Yee Khong

  3. Department of Histopathology, University Hospitals of Leicester NHS Trust Leicester Royal Infirmary, Leicester, UK

    Roger D. G. Malcomson

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Charles, A.K. (2015). Congenital Tumors. In: Khong, T.Y., Malcomson, R.D.G. (eds) Keeling’s Fetal and Neonatal Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-19207-9_18

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