Abstract
The primary goal of treating patients with psoriatic arthritis (PsA) is to maximise health-related quality of life (HRQoL), through control of symptoms, prevention of structural damage, and normalization of function and social participation [1]. Treatment goals in PsA should aim at reaching an acceptable disease state as agreed by both patient and physician [2]. In 2009, minimal disease activity (MDA) criteria, the first potential target for treatment in PsA were published.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Smolen JS, Braun J, Dougados M, et al. Treating spondylarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force. Ann Rheum Dis. 2014;73:6-16.
Coates LC, Cook R, Lee KA, et al. Frequency, predictors, and prognosis of sustained minimal disease activity in an observational psoriatic arthritis cohort. Arthritis Care Res (Hoboken). 2010;62:970.
Coates LC, Moverley AR, McParland L, et al. Effect of tight control of inflammation in early psoriatic arthritis (TICOPA): a UK multicentre, open-label, randomised controlled trial. Lancet. 2015; [Epub ahead of print} doi: 10.1016/S0140-6736(15)00347-5.
Elmamoun M, Ni Mhuircheartaigh O, Kane D, et al. National recommendations for the treatment of psoriatic arthritis. Ir J Med Sci. 2014;184(Suppl 6):Abstract 43 (14A144).
Sarzi-Puttini P, Santandrea S, Boccassini L, et al. The role of NSAIDs in psoriatic arthritis: evidence from a controlled study with nimesulide. Clin Exp Rheumatol. 2001;19:S17-S20.
Kivitz AJ, Espinoza LR, Sherrer YR, Liu-Dumaw M, West CR. A comparison of the efficacy and safety of celecoxib 200Â mg and celecoxib 400Â mg once daily in treating the signs and symptoms of psoriatic arthritis. Semin Arthritis Rheum. 2007;37:164-173.
Soriano ER, McHugh NJ. Therapies for peripheral joint disease in psoriatic arthritis: a systematic review. J Rheumatol. 2006;33:1422-1430.
Scarpa R, Peluso R, Atteno M, et al. The effectiveness of a traditional therapeutical approach in early psoriatic arthritis: Results of a pilot randomised 6-month trial with methotrexate. Clin Rheumatol. 2008;27:823-826.
Kingsley GH, Kowalczyk A, Taylor H, et al. A randomized placebo-controlled trial of methotrexate in psoriatic arthritis. Rheumatology (Oxford). 2012; 51:1368-1377.
Kaltwasser JP, Nash P, Gladman D, et al. Efficacy and safety of leflunomide in the treatment of psoriatic arthritis and psoriasis: a multinational, double-blind, randomized, placebo- controlled clinical trial. Arthritis Rheum. 2004;50:1939-1950.
Clegg DO, Reda DJ, Mejias E, et al. Comparison of sulfasalazine and placebo in the treatment of psoriatic arthritis. A Department of Veterans Affairs Cooperative Study. Arthritis Rheum. 1996;39:2013-2020.
Fraser AD, van Kuijk AW, Westhovens R, et al. A randomised, double blind, placebo controlled, multicentre trial of combination therapy with methotrexate plus ciclosporin in patients with active psoriatic arthritis. Ann Rheum Dis. 2005;64:859-864.
Gladman DD, Blake R, Brubacher B, Farewell VT. Chloroquine therapy in psoriatic arthritis. J Rheumatol. 1992;19:1724-1726.
Levy J, Paulus HE, Barnett EV, et al. A double-blind controlled evaluation of azathioprine treatment in rheumatoid arthritis and psoriatic arthritis. Arthritis Rheum.1972;15:116-117.
Mease PJ, Kivitz AJ, Burch FX, et al. Etanercept treatment of psoriatic arthritis: safety, efficacy, and effect on disease progression. Arthritis Rheum. 2004;50:2264-2272.
Antoni C, Krueger GG, de Vlam K, et al. Infliximab improves signs and symptoms of psoriatic arthritis: results of the IMPACT 2 trial. Ann Rheum Dis. 2005;64:1150-1157.
Mease PJ, Gladman DD, Ritchlin CT, et al. Adalimumab for the treatment of patients with moderately to severely active psoriatic arthritis: results of a double-blind, randomized, placebo controlled trial. Arthritis Rheum. 2005;52:3279-3289.
Kavanaugh A, Mclness I, Mease P, et al. Golimumab, a new human tumor necrosis factor a antibody, administered every 4Â weeks as a subcutaneous injection in psoriatic arthritis: Twenty-four-week efficacy and safety results of a randomized, placebo-controlled study. Arthritis Rheum. 2009;60:976-986.
Kavanaugh A, McInnes IB, Mease P, et al. Clinical efficacy, radiographic and safety findings through 5Â years of subcutaneous golimumab treatment in patients with active psoriatic arthritis: results from a long-term extension of a randomised, placebo-controlled trial (the GO-REVEAL study). Ann Rheum Dis. 2014;73:1689-1694.
Mease PJ, Fleischmann R, Deodhar AA, et al. Effect of certolizumab pegol on signs and symptoms in patients with psoriatic arthritis: 24-week results of a Phase 3 double-blind randomized placebo-controlled study (RAPID-PsA). Ann Rheum Dis. 2014;73:48-55.
Mease PJ, Fleischmann RM, Wollenhaupt J, et al. Effect of certolizumab pegol over 48Â weeks 0n signs and symptoms in patients with psoriatic arthritis with and without prior tumor necrosis factor inhibitor exposure. Abstract # 312. Arthritis Rheum. 2013;S132.
Van der Heijde D, Fleischmann R, Wollenhaupt J, et al. Effect of different imputation approaches on the evaluation of radiographic progression in patients with psoriatic arthritis: result of the RAPID-PsA 24-weekphase III double-blind randomised placebo-controlled study of certolizumab pegol. Ann Rheum Dis. 2014;73:233-237.
McInnes IB, Kavanaugh A, Gottlieb AB, et al. Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1Â year results of the phase 3, multicentre, double-blind, placebo- controlled PSUMMIT 1 trial. Lancet. 2013;382:780-789.
FitzGerald O. Spondyloarthropathies: apremilast: welcome advance in treatment of psoriatic arthritis. Nat Rev Rheumatol. 2014;10:385-386.
Kavanaugh A, Mease PJ, Gomez-Reino JJ, et al. Treatment of psoriatic arthritis in a phase 3 randomized, placebo-controlled trial with apremilast, an oral phosphodiesterase 4 inhibitor. Ann Rheum Dis. 2014;73:1020-1026.
Mclnnes IB, Mease PJ, Kirkham B, et al. Secukinumab, a human anti-interleukin-17A monoclonal antibody, in patients with psoriatic arthritis (FUTURE 2): a randomised, double- blind, placebo-controlled, phase 3trial. Lancet. 2015 [Epub ahead of print]; doi:10.1016/S0140-6736(15)61134-5.
Mease PJ, Genovese MC, Greenwald MW, et al. Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritis. N Engl J Med. 2014;370:2295-2306.
Mease P, Genovese MC, Gladstein G, et al. Abatacept in the treatment of patients with psoriatic arthritis: Results of a six-month, multicenter, randomized, double-blind, placebo-controlled, phase II trial. Arthritis Rheum. 2011;63:939-948.
Leonardi C, Matheson R, Zachariae C, et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic psoriasis. N Engl J Med. 2012;366:1190-1199.
Eli Lilly and Company. A Study of Ixekizumab in Participants With Active Psoriatic Arthritis (SPIRIT-P1). https://clinicaltrials.gov/ct2/show/NCT01695239. Accessed October 15, 2015.
Zangger P, Gladman DD, Bogoch ER. Musculoskeletal surgery in psoriatic arthritis. J Rheumatol. 1998;25:725-729.
Lambert JR, Wright V. Surgery in patients with psoriasis and arthritis. Rheumatol Rehabil. 1979;18:35-37.
Zangger P, Esufali ZH, Gladman DD, et al. Type and outcome of reconstructive surgery for different patterns of psoriatic arthritis. J Rheumatol. 2000;27:967-974.
Hicken GJ, Kitaoka HB, Valente RM. Foot and ankle surgery in patients with psoriasis. Clin Orthop Relat Res. 1994;300:201-206.
Husted JA, Tom BD, Farewell VT, Schentag CT, Gladman DD. A longitudinal study of the effect of disease activity and clinical damage on physical function over the course of psoriatic arthritis: does the effect change over time? Arthritis Rheum. 2007;56:840-849.
Dalal DS, Lin YC, Brennan DM, Borkar N, Korman N, Husni ME. Quantifying harmful effects of psoriatic disease on quality of life: cardio-metabolic outcomes in psoriatic arthritis study (COMPASS). Semin Arthritis Rheum. 2015;44:641-645.
Rosen CF, Mussani F, Chandran V, Eder L, Thavaneswaren A, Gladman DD. Patients with psoriatic arthritis have worse quality of life than those with psoriasis alone. Rheumatology (Oxford). 2012;51:571-576.
Lee S, Mendelsohn A, Sarnes E. The burden of psoriatic arthritis: a literature review from a global health systems perspective. PT. 2010;35:680-689.
Saad AA, Ashcroft DM, Watson KD, et al. Improvement in quality of life and functional status in patients with psoriatic arthritis receiving anti-tumor necrosis factor therapies. Arthritis Care Res (Hoboken). 2010;62:345-353.
Eder L, Jayakar J, Shanmugarajah S, et al. The burden of carotid artery plaques is higher in patients with psoriatic arthritis compared with those with psoriasis alone. Ann Rheum Dis. 2013;72:715-720.
Mok C, Ko G, Ho L, et al. Prevalence of atherosclerotic risk factors and the metabolic syndrome in patients with chronic inflammatory arthritis. Arthritis Care Res. 2011;62:19-202.
Haroon M, Gallagher P, Heffernan E, et al. High prevalence of metabolic syndrome and of insulin resistance in psoriatic arthritis is associated with the severity of underlying disease. J Rheumatol. 2014;41:1357-1365.
Jamnitski A, Symmons D, Peters MJ, et al. Cardiovascular comorbidities in patients with psoriatic arthritis: a systematic review. Ann Rheum Dis. 2013;72:211-216.
Peters MJ, Symmons DP, McCarey D, et al. EULAR evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis and other forms of inflammatory arthritis. Ann Rheum Dis. 2010;69:325-331.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Elmamoun, M., Fitzgerald, O. (2016). Treatment of psoriatic arthritis. In: Warren, R., Menter, A. (eds) Handbook of Psoriasis and Psoriatic Arthritis. Adis, Cham. https://doi.org/10.1007/978-3-319-18227-8_6
Download citation
DOI: https://doi.org/10.1007/978-3-319-18227-8_6
Published:
Publisher Name: Adis, Cham
Print ISBN: 978-3-319-18226-1
Online ISBN: 978-3-319-18227-8
eBook Packages: MedicineMedicine (R0)