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Neonatal Cholestasis-Conjugated Hyperbilirubinemia

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Neonatology

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Abstract

Jaundice during the first few weeks of life is a common finding. Frequently, such jaundice is due to elevation of the unconjugated, or indirect, bilirubin and is often the result of a benign process. More concerning is jaundice due to elevation of the conjugated bilirubin fraction. Neonatal cholestasis is defined as an accumulation of biliary substances, such as bilirubin and bile acids because of impaired canalicular bile flow. Neonatal cholestasis manifests with a conjugated hyperbilirubinemia and must be differentiated from unconjugated hyperbilirubinemia, as it is more often associated with a specific disease process. The incidence of neonatal cholestasis has been estimated at 1 in 2,500 live births.

A chapter prepared for Dr. Giuseppe Buonocore’s Neonatology textbook.

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Authors and Affiliations

  1. Department of Pediatrics, University of Minnesota, 421 West Broadway, Long Beach, California, 90802, United States

    Nandini Kataria

  2. Department of Pediatrics, University of Minnesota, Minneapolis, USA

    Glenn R. Gourley

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  1. Nandini Kataria
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  2. Glenn R. Gourley
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Correspondence to Nandini Kataria .

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  1. Siena, Italy

    Giuseppe Buonocore

  2. Medicina della Riproduzione, Università di Siena Dipto. Pediatria, Ostetricia e, Siena, Italy

    Rodolfo Bracci

  3. Liverpool Women's Hospital Neonatal Unit, Liverpool, United Kingdom

    Michael Weindling

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Kataria, N., Gourley, G.R. (2016). Neonatal Cholestasis-Conjugated Hyperbilirubinemia. In: Buonocore, G., Bracci, R., Weindling, M. (eds) Neonatology. Springer, Cham. https://doi.org/10.1007/978-3-319-18159-2_225-1

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  • DOI: https://doi.org/10.1007/978-3-319-18159-2_225-1

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